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[ CAS No. 882847-32-7 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}

2D 3D

Chemical Structure| 882847-32-7

Chemical Structure| 882847-32-7

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Quality Control of [ 882847-32-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 882847-32-7 ]

SDS Specification

Alternatived Products of [ 882847-32-7 ]

Product Details of [ 882847-32-7 ]

CAS No. :	882847-32-7	MDL No. :	MFCD06656473
Formula :	C₂₈H₃₇NO₉	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	TWQTXZPTZPOEEB-UHFFFAOYSA-N
M.W :	531.59	Pubchem ID :	2756187
Synonyms :		Chemical Name :	1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid

Calculated chemistry of [ 882847-32-7 ]

Physicochemical Properties

Num. heavy atoms :	38
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.5
Num. rotatable bonds :	22
Num. H-bond acceptors :	9.0
Num. H-bond donors :	2.0
Molar Refractivity :	138.67
TPSA :	121.78 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	Yes
Log Kp (skin permeation) :	-8.25 cm/s

Lipophilicity

Log Po/w (iLOGP) :	4.79
Log Po/w (XLOGP3) :	1.82
Log Po/w (WLOGP) :	3.08
Log Po/w (MLOGP) :	0.51
Log Po/w (SILICOS-IT) :	4.57
Consensus Log Po/w :	2.95

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	1.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-3.06
Solubility :	0.459 mg/ml ; 0.000863 mol/l
Class :	Soluble
Log S (Ali) :	-4.0
Solubility :	0.0535 mg/ml ; 0.000101 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-7.82
Solubility :	0.00000805 mg/ml ; 0.0000000151 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	4.93

Safety of [ 882847-32-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 882847-32-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 882847-32-7 ]

[ 882847-32-7 ] Synthesis Path-Downstream 1~26

1
[ 882847-32-7 ]
[ 1261156-61-9 ]
[ 1261156-62-0 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

2
[ 882847-32-7 ]
[ 1261156-76-6 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

3
[ 882847-32-7 ]
[ 1261156-79-9 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

4
[ 882847-32-7 ]
[ 1261156-82-4 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

5
[ 882847-32-7 ]
C₃₈H₆₅N₃O₁₉ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

6
[ 882847-32-7 ]
C₄₈H₉₁N₃O₁₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

7
[ 882847-32-7 ]
C₅₄H₁₀₃N₃O₁₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

8
[ 882847-32-7 ]
C₅₅H₉₇N₃O₁₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

9
[ 882847-32-7 ]
[ 1261156-65-3 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

10
[ 882847-32-7 ]
[ 1261156-68-6 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

11
[ 882847-32-7 ]
[ 1261156-71-1 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 6670 - 6675

12
[ 1214891-99-2 ]
[ 882847-32-7 ]
C₂₇H₃₁N₄O₄PolS [ No CAS ]
[ 71989-26-9 ]
C₇₅H₁₂₀N₁₆O₂₁S [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 4066 - 4069

13
polyethylene glycol polyamide resin [ No CAS ]
[ 1032815-88-5 ]
[ 882847-32-7 ]
[ 146982-27-6 ]
[ 198561-07-8 ]
C₇₁H₁₀₈N₈O₁₇Pol⁽¹⁺⁾ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 3085 - 3093

14
[ 882847-32-7 ]
C₅₅H₇₉N₁₃O₉ [ No CAS ]
C₁₁₁H₁₄₉N₁₅O₂₅ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 3085 - 3093

15
[ 882847-32-7 ]
C₃₅H₅₁N₇O₅ [ No CAS ]
C₅₉H₇₆N₁₀O₁₂PPol [ No CAS ]
C₇₇H₁₂₃N₁₈O₂₂P [ No CAS ]

Reference： [1]ChemBioChem,2016,vol. 17,p. 759 - 767

16
[ 29022-11-5 ]
[ 882847-32-7 ]
[ 92122-45-7 ]
[ 35661-38-2 ]
[ 35661-60-0 ]
[ 71989-31-6 ]
[ 75932-02-4 ]
Fmoc-D-Asp(PG)-OH [ No CAS ]
Fmoc-D-Arg(PG)-OH [ No CAS ]
Fmoc-D-His(PG)-OH [ No CAS ]
Fmoc-D-Trp(PG)-OH [ No CAS ]
Fmoc-D-Ser(PG)-OH [ No CAS ]
C₁₃₆H₂₁₉N₃₉O₃₉ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: The Rink amide resin (1 equiv) was added to the reaction container, washed with DCM and DMF, and deprotected twice with 20% piperidine in DMF for 10 min each time. The Fmoc-Lys(Fmoc)-OH (5 equiv), HOBt (5 equiv) and DIC (5 equiv) were added together with 2 mL DMF and reacted for 4 h, The two Fmoc groups of lysine were deprotected and coupled with different linker (10 equiv) together with HOBt (10 equiv) and DIC (10 equiv) in 2 mL DMF for 6 h. Fmoc-NH-(PEG)mCH2CH2-COOH (MW = 443.50) was used to synthesized peptides 4-18. Different lengths of the DV3 sequence, from the C-terminal to the N-terminal, were then coupled onto the PEG linker through Fmoc-D-aa by the same method used for coupling of the linker. For peptides 15, 16, 17, and 18, the amino acid of DV3 at position 7, 8, 9, and 10 was mutated into alanine, respectively. The Fmoc groups of last amino acids acid was deprotected, and the peptide was then cleaved from the resin with the cocktail cleavage solution (TFA/H2O/Thiophenol = 90:5:5). The crude peptid ewas precipitated and washed twice with cold ethyl ether.

Reference： [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 5393 - 5399

17
[ 29022-11-5 ]
[ 882847-32-7 ]
[ 35661-38-2 ]
[ 35661-60-0 ]
[ 71989-31-6 ]
[ 75932-02-4 ]
Fmoc-D-Arg(PG)-OH [ No CAS ]
Fmoc-D-His(PG)-OH [ No CAS ]
Fmoc-D-Trp(PG)-OH [ No CAS ]
Fmoc-D-Ser(PG)-OH [ No CAS ]
C₁₁₆H₁₈₅N₃₃O₃₁ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: The Rink amide resin (1 equiv) was added to the reaction container, washed with DCM and DMF, and deprotected twice with 20% piperidine in DMF for 10 min each time. The Fmoc-Lys(Fmoc)-OH (5 equiv), HOBt (5 equiv) and DIC (5 equiv) were added together with 2 mL DMF and reacted for 4 h, The two Fmoc groups of lysine were deprotected and coupled with different linker (10 equiv) together with HOBt (10 equiv) and DIC (10 equiv) in 2 mL DMF for 6 h. Fmoc-NH-(PEG)mCH2CH2-COOH (MW = 443.50) was used to synthesized peptides 4-18. Different lengths of the DV3 sequence, from the C-terminal to the N-terminal, were then coupled onto the PEG linker through Fmoc-D-aa by the same method used for coupling of the linker. For peptides 15, 16, 17, and 18, the amino acid of DV3 at position 7, 8, 9, and 10 was mutated into alanine, respectively. The Fmoc groups of last amino acids acid was deprotected, and the peptide was then cleaved from the resin with the cocktail cleavage solution (TFA/H2O/Thiophenol = 90:5:5). The crude peptid ewas precipitated and washed twice with cold ethyl ether.

Reference： [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 5393 - 5399

18
[ 867062-95-1 ]
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-60-0 ]
[ 882847-32-7 ]
[ 16937-99-8 ]
[ 71989-31-6 ]
[ 92122-45-7 ]
[ 71989-26-9 ]
[ 35661-38-2 ]
[ 71989-31-6 ]
[ 150629-67-7 ]
Fmoc-D-Asp(PG)-OH [ No CAS ]
Fmoc-D-Arg(PG)-OH [ No CAS ]
Fmoc-D-His(PG)-OH [ No CAS ]
Fmoc-D-Trp(PG)-OH [ No CAS ]
Fmoc-D-Ser(PG)-OH [ No CAS ]
Fmoc-Ser(PG)-OH [ No CAS ]
C₁₁₉H₁₉₆N₃₄O₃₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: The Rink amide resin (1 equiv) was washed with DCM and DMF in the reaction container, and deprotected twice with 20% piperidine in DMF for 10 min each time. The Fmoc-Lys(dde)-OH (5 equiv), HOBt (5 equiv) and DIC (5 equiv) were coupled with resinin 2 mL DMF for 4 h. For peptides 21-24, one PEG linker was coupled to the N-alpha position of the first lysine using Fmoc-NH-(PEG)3-CH2CH2-COOH (MW = 443.50). The DV3 sequence from the Cterminalto the N-terminal was coupled onto the PEG linker with the last D-amino acid protected by Boc group. After the coupling of the DV3 sequence was complete, the dde group of the first coupled lysine was deprotected with 2% hydrazine in DMF. Then, the other PEG linker was coupled onto the epsilon-amino group of the first coupled lysine and the sequence of CXCL121-8 from the C-terminal to N-terminal was coupled onto the PEG linker through Fmoc-L-aa (5 equiv), HOBt (5 equiv) and DIC (5 equiv) in 2 mL DMF. For peptide 20, the DV3 and CXCL121-8 sequences was directly coupled to the alpha and epsilon amino groups of the first lysine, respectively. The Fmoc groups of last amino acids acid was deprotected before washing with DMF and DCM, then the peptide was cleaved from the resin with a cocktail cleavage solution (TFA/H2O/Thiophenol = 90:5:5) for 2 h. The crude peptide was precipitated and washed twice with cold ethyl ether.

Reference： [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 5393 - 5399

19
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-60-0 ]
[ 882847-32-7 ]
[ 16937-99-8 ]
[ 71989-31-6 ]
[ 92122-45-7 ]
[ 71989-26-9 ]
[ 35661-38-2 ]
[ 71989-31-6 ]
[ 150629-67-7 ]
Fmoc-D-Asp(PG)-OH [ No CAS ]
Fmoc-D-Arg(PG)-OH [ No CAS ]
Fmoc-D-His(PG)-OH [ No CAS ]
Fmoc-D-Trp(PG)-OH [ No CAS ]
Fmoc-D-Ser(PG)-OH [ No CAS ]
Fmoc-Arg(PG)-OH [ No CAS ]
Fmoc-Tyr(PG)-OH [ No CAS ]
Fmoc-Ser(PG)-OH [ No CAS ]
C₁₂₇H₂₁₂N₃₄O₃₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: The Rink amide resin (1 equiv) was washed with DCM and DMF in the reaction container, and deprotected twice with 20% piperidine in DMF for 10 min each time. The Fmoc-Lys(dde)-OH (5 equiv), HOBt (5 equiv) and DIC (5 equiv) were coupled with resinin 2 mL DMF for 4 h. For peptides 21-24, one PEG linker was coupled to the N-alpha position of the first lysine using Fmoc-NH-(PEG)3-CH2CH2-COOH (MW = 443.50). The DV3 sequence from the Cterminalto the N-terminal was coupled onto the PEG linker with the last D-amino acid protected by Boc group. After the coupling of the DV3 sequence was complete, the dde group of the first coupled lysine was deprotected with 2% hydrazine in DMF. Then, the other PEG linker was coupled onto the epsilon-amino group of the first coupled lysine and the sequence of CXCL121-8 from the C-terminal to N-terminal was coupled onto the PEG linker through Fmoc-L-aa (5 equiv), HOBt (5 equiv) and DIC (5 equiv) in 2 mL DMF. For peptide 20, the DV3 and CXCL121-8 sequences was directly coupled to the alpha and epsilon amino groups of the first lysine, respectively. The Fmoc groups of last amino acids acid was deprotected before washing with DMF and DCM, then the peptide was cleaved from the resin with a cocktail cleavage solution (TFA/H2O/Thiophenol = 90:5:5) for 2 h. The crude peptide was precipitated and washed twice with cold ethyl ether.

Reference： [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 5393 - 5399

20
[ 13094-51-4 ]
[ 882847-32-7 ]
[ 544-63-8 ]
[ 204777-78-6 ]
C₃₅H₆₆BrN₃O₁₀ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Fmoc-Lys--N-Dde 500 mg of resin (0.15 mmoles) was treated with 20% piperidine and then washed with DMF (3x), DCM (3x). The resin was then treated with Myristic acid (10 eq.) along with DIEA, HATU and the coupling continued for 2 hours. Dde was removed using 2% Hydrazine in DMF (2X) and then washed with DMF and DCM. Acid-PegS-Fmoc acid was then coupled using DIEA, HATU overnight. After confirming the coupling reaction withnihydrin test, Fmoc was cleaved and then the free amine is allowed to react with bromo acetic anhydride in the presence of base to generate the desired compounds FA-182 on resin. After washing with DCM (3x), the product was cleaved from the resin using 5 mL of 50% TFA in DCM containing 10% H20 and 10% triisopropylsilane for 2 h. After cleavage, the cleaved solution was died and then re-dissolved by methanol/DMF before subjecting to HPLC purification. The fractions sonjtaing the product were combined and freese dried to afford FA182 (ESI-MS calculated MW 768.2.; found 769.4 [M+1]

Reference： [1]Patent: WO2016/149501,2016,A2 .Location in patent: Paragraph 0352

21
[ 882847-32-7 ]
C₁₇H₃₆N₄O₆*2ClH [ No CAS ]
C₇₃H₁₀₆N₆O₂₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 14h;Inert atmosphere;	Preparation of Compound 32a DIPEA (0.6 mL, 7.07 mmol) and HBTU (972 mg, 5.30 mmol) were added to a stirring mixture of compound 24g (483 mg, 0.855 mmol) and Fmoc-NH-PEG5- CH2CH2COOH (1.0 g, 3.89 mmol) in DMF (10 mL). After stirring at room temperature for 14 hours under N2, the reaction mixture was poured into H2O (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with 1 N aq. HCl (10 mL), saturated aq. NaHCO3 (10 mL) and brine (10 mL) sequentially, and dried over anhydrous Na2SO4. After filtration and concentration, the resulting residue was purified by column chromatography, which produced the compound 32a (1.16 g, 90 %). 1H-NMR (400 MHz, CDC13) delta 7.77 (d, 4H), 7.60(d, 4H), 7.39 (t, 4H), 7.31 (t, 4H), 4.39 (d, 4H), 4.33 (m, 1H), 4.22 (m, 2H), 4.09 (m, 2H), 3.71-3.39 (m, 52H), 3.19 (m, 2H), 2.51 (m, 4H), 1.50 (m, 1H), 1.46 (m, 1H), 1.43 (s, 9H), 1.25 (m, 2H). EI-MS m/z: [M+H]+ 1520.0.
90%	With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 14h;Inert atmosphere;	DIPEA (0.6 mL, 7.07 mmol) and HBTU (972 mg, 5.30 mmol) were added to a stirring mixture of compound 24g (483 mg, 0.855 mmol) and Fmoc- H-PEG5- CH2CH2COOH (1.0 g, 3.89 mmol) in DMF (10 mL). After stirring at room temperature for 14 hours under N2, the reaction mixture was poured into H20 (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with 1 N aq. HCl (10 mL), saturated aq. NaHC03 (10 mL) and brine (10 mL) sequentially, and dried over anhydrous Na2S04. After filtration and concentration, the resulting residue was purified by column chromatography, which produced the compound 32a (1.16 g, 90 %). 1H- MR (400 MHz, CDC13) delta 7.77 (d, 4H), 7.60(d, 4H), 7.39 (t, 4H), 7.31 (t, 4H), 4.39 (d, 4H), 4.33 (m, 1H), 4.22 (m, 2H), 4.09 (m, 2H), 3.71-3.39 (m, 52H), 3.19 (m, 2H), 2.51 (m, 4H), 1.50 (m, 1H), 1.46 (m, 1H), 1.43 (s, 9H), 1.25 (m, 2H). EI-MS m/z: [M+H]+ 1520.0.

Reference： [1]Patent: WO2017/89890,2017,A1 .Location in patent: Page/Page column 137; 138
[2]Patent: WO2017/89894,2017,A1 .Location in patent: Page/Page column 147; 148

22
H-cys(4-methoxytrityl)-2-chlorotrityl-resin [ No CAS ]
[ 882847-32-7 ]
[ 71989-14-5 ]
[ 71989-18-9 ]
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ]
[ 115134-37-7 ]
C₅₁H₇₂N₁₆O₂₂S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
413 mg		In a peptide synthesis vessel was added the resin, amino acid solution, iPr2NEt, and PyBOP. Argon was bubbled through the solution for 1 h and then washed 3X with DMF and IPA. A solution of 20% piperdine in DMF for FMOC deprotection was added, 2X (10mm), before each amino acid coupling. This was continued to complete all seven coupling steps.Cleavage step:25 mL of cleavage reagent (92.5% TFA, 2.5% H20, 2.5% Triisopropylsaline, 2.5% (1.34m1) ethandithiol) was added to the peptide synthesis vessel and Argon was bubbled for 1.5 h, drain, and wash 3X with cleavage reagent reagent. The reaction mixture was concentrated under reduced pressure until lOml remained. The product was triturated in ethyl ether andcentrifuge. The resulting pellet was dried under high vacuum.Deprotection step:Crude protected Compound 99 was added to lOml water. The pH adjusted to 9.3 and maintained for 1 h using potassium carbonate. After 1 h the solution was adjusted to pH 5 with iN HC1. The reaction mixture was load directly onto a C18 reverse phase column and purifiedvia with 0- 35% CH3CN/50 mM NH4HCO3 buffer, pH 7.0 to yield 413 mg Compound 99 asfluffy yellow solid.

Reference： [1]Patent: WO2017/172930,2017,A1 .Location in patent: Page/Page column 174; 175; 176; 177

23
[ 882847-32-7 ]
[ 1353016-71-3 ]
[ 103213-32-7 ]
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ]
C₇₃H₁₀₂N₁₂O₁₇S₃ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2018,vol. 57,p. 6459 - 6463
Angew. Chem.,2018,vol. 130,p. 6569 - 6573,5

24
[ 882847-32-7 ]
C₆₀H₇₇N₁₀O₉PolS₃ [ No CAS ]
C₇₃H₁₀₂N₁₁O₁₅PolS₃ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2018,vol. 57,p. 6459 - 6463
Angew. Chem.,2018,vol. 130,p. 6569 - 6573,5

25
[ 882847-32-7 ]
C₁₃H₇NO₆ [ No CAS ]
C₂₆H₃₂N₂O₁₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2018,vol. 57,p. 11554 - 11558
Angew. Chem.,2018,vol. 130,p. 11728 - 11732,5

26
[ 159610-89-6 ]
[ 882847-32-7 ]
C₁₃H₇NO₆ [ No CAS ]
C₃₂H₄₃N₇O₁₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2018,vol. 57,p. 11554 - 11558
Angew. Chem.,2018,vol. 130,p. 11728 - 11732,5

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere