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Chemical Structure| 884497-40-9 Chemical Structure| 884497-40-9

Structure of 884497-40-9

Chemical Structure| 884497-40-9

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Product Details of [ 884497-40-9 ]

CAS No. :884497-40-9
Formula : C10H9FN2S
M.W : 208.26
SMILES Code : NC1=NC=C(CC2=CC=CC(F)=C2)S1
MDL No. :MFCD05863658

Safety of [ 884497-40-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 884497-40-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 884497-40-9 ]

[ 884497-40-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3719-45-7 ]
  • [ 884497-40-9 ]
  • N-(5-(3-fluorobenzyl)thiazol-2-yl)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
54.6% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 16h; To a solution of 1 -methyl-6-oxo-1 ,6-dihydropyridine-3-carboxylic acid (0.367 g, 2.4 mmol), 5-(3-fluorobenzyl)thiazol-2-amine (0.500 mg, 2.4 mmol) and 1 -[b/s(dimethylamino)methylene]- 1H- 1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (1 .1 9 g, 3.12 mmol) in A/,A/-dimethylformamide (6 ml_) was added A/,A/-diisopropylethylamine (1 .24 g, 9.6 mmol). The mixture was stirred at room temperature for 16 h. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified wa prep-HPLC (Boston C18 21 *250 mm 10 pm column; acetonitrile/0.01 % aqueous trifluoroacetic acid) to give A/-(5-(3-fluorobenzyl)thiazol-2-yl)-1 -methyl-6-oxo-1 ,6-dihydropyridine-3-carboxamide (0.450 g, 1 .31 mmol, 54.6%) as a white solid. 1 H NMR (500 MHz, Dimethylsulfoxide-c/6) d 12.22 (s, 1 H), 8.68 (d, J = 2.4 Hz, 1 H), 7.99 (dd, J = 9.5, 2.7 Hz, 1 H), 7.40 - 7.32 (m, 2H), 7.14 - 7.04 (m, 3H), 6.44 (d, J = 9.6 Hz, 1 H), 4.13 (s, 2H), 3.50 (s, 3H); LCMS (ESI) m/z: 334.0 [M+H]+.
 

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