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Chemical Structure| 884504-63-6 Chemical Structure| 884504-63-6

Structure of 884504-63-6

Chemical Structure| 884504-63-6

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Product Details of [ 884504-63-6 ]

CAS No. :884504-63-6
Formula : C10H8BrNO
M.W : 238.08
SMILES Code : N#CCCC(C1=CC=CC(Br)=C1)=O
MDL No. :MFCD02260539

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Application In Synthesis of [ 884504-63-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 884504-63-6 ]

[ 884504-63-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 884504-63-6 ]
  • [ 899350-32-4 ]
YieldReaction ConditionsOperation in experiment
2.9 g With water; hydrazine hydrate; potassium hydroxide In ethylene glycol at 195℃; Step 2: To a solution of the isolated nitrile (3.1 g, 13.0 mmol) in ethylene glycol (22 mL) was added water (0.5 mL), hydrazine monohydrate (1.5 mL) and potassium hydroxide (3.34 g). The reaction mixture was heated to 195 °C until analysis by LCMS indicated complete reaction, after which it was allowed to cool to room temperature, diluted with water and acidifed to pH ~2 with 2N HCl. The resulting solution was extracted with EtOAc, dried (MgS04), filtered and evaporated in vacuo. Purification of the residue on silica gel (0 to 30percent acetone in hexanes) afforded 2.9 g of the title acid
References: [1] Patent: WO2014/99503, 2014, A1, . Location in patent: Paragraph 0098.
 

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• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Blaise Reaction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Ritter Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Thorpe-Ziegler Reaction • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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