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Chemical Structure| 88512-06-5 Chemical Structure| 88512-06-5

Structure of 88512-06-5

Chemical Structure| 88512-06-5

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Product Details of [ 88512-06-5 ]

CAS No. :88512-06-5
Formula : C5H12ClNO2
M.W : 153.61
SMILES Code : O=C(OC)C(C)CN.[H]Cl
MDL No. :MFCD16547718
InChI Key :RVPWGKBKRYTOHJ-UHFFFAOYSA-N
Pubchem ID :13063725

Safety of [ 88512-06-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 88512-06-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88512-06-5 ]

[ 88512-06-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 88512-06-5 ]
  • [ 15518-10-2 ]
YieldReaction ConditionsOperation in experiment
86% With lithium aluminium tetrahydride; In tetrahydrofuran; at 0℃; for 3h;Inert atmosphere; Reflux; D1 (2.0 g, 13.0 mmol) was added portionwise to a suspension of LiAIH4 (1.4 g, 39.2 mmol) in THF (75 ml_) under nitrogen atmosphere at 0 C. The reaction mixture was stirred for 30 minutes and then allowed to stir at room temperature for another 30 minutes. The reaction mixture was refluxed for 2 h, and then it was cooled to -10 C and quenched carefully with ice cold water (1.4 ml_). 10% NaOH solution (2.8 ml_) and ice cold water (4.2 ml_) were added, and the mixture was stirred for 15 minutes. It was filtered, and the filtrate washed with EtOAc (3 x 100 ml_), dried over anhydrous Na2S04 and concentrated under vacuum to obtain D2 (1.2 g, 86%) as a pale yellow liquid. Rf: 0.2 (20% MeOH in DCM). 1H NMR (400 MHz, cf6-DMSO): delta 0.78 (d, J = 6.8 Hz, 3H), 1.46 - 1.54 (m, 1 H), 2.41 - 2.45 (m, 2H), 2.50 - 2.54 (m, 1 H), 3.22 - 3.34 (m, 4H).
 

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