[ CAS No. 885270-86-0 ]

Name: 885270-86-0|tert-Butyl 2,6-diazaspiro[3.4]octane-6-carboxylate|95%
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Quality Control of [ 885270-86-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 885270-86-0 ]

CAS No. :	885270-86-0	MDL No. :	MFCD08234738
Formula :	C₁₁H₂₀N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BGUYAMZPJMTFRU-UHFFFAOYSA-N
M.W :	212.29	Pubchem ID :	46835579
Synonyms :

Calculated chemistry of [ 885270-86-0 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.91
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	65.74
TPSA :	41.57 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.1 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.66
Log Po/w (XLOGP3) :	0.7
Log Po/w (WLOGP) :	0.46
Log Po/w (MLOGP) :	1.15
Log Po/w (SILICOS-IT) :	1.05
Consensus Log Po/w :	1.2

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.4
Solubility :	8.47 mg/ml ; 0.0399 mol/l
Class :	Very soluble
Log S (Ali) :	-1.15
Solubility :	15.0 mg/ml ; 0.0707 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.82
Solubility :	3.19 mg/ml ; 0.015 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.71

Safety of [ 885270-86-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 885270-86-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 885270-86-0 ]

[ 885270-86-0 ] Synthesis Path-Downstream 1~30

2
[ 885270-86-0 ]
C₂₂H₂₁F₂N₃O₄ [ No CAS ]
[ 76-05-1 ]
(4-(5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-2-yl)phenyl)(2,6-diazaspiro[3.4]octan-2-yl)methanone 2,2,2-trifluoroacetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
8%		To a 5 mL screw-cap reaction tube was added compound A-9 4-(7-(difluoromethyl)-5-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-2-yl)benzoic acid (20.0 mg, 0.045 mmol), <strong>[885270-86-0]tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate</strong> (18.98 mg, 0.089 mmol), HATU (18.7 mg, 0.049 mmol), NMP (0.500 ml), and Huenig's Base (6.00 ul, 0.044 mmol). The reaction mixture was stirred at 30 C. overnight. The material was purified by LC/MS using HPLC condition III. The fractions containing product were combined and concentrated in vacuo. The resulting material was then taken up in ethanol (1.0 ml) and 50% trifluoroacetic acid in DCM (1.0 ml, 4.00 mmol) and the mixture stirred at RT for 1 h. The mixture was then concentrated in vacuo to give compound ER-895080 as a yellow solid (2.40 mg, 8% yield).

Reference： [1]Patent: US2013/324547,2013,A1 .Location in patent: Paragraph 0283

3
[ 885270-86-0 ]
4,6-dichloro-8-fluoro-7-(2-fluoro-6-methoxyphenyl)quinazoline [ No CAS ]
tert-butyl 2-(6-chloro-8-fluoro-7-(2-fluoro-6-methoxyphenyl)quinazolin-4-yl)-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine; In dichloromethane; at 20℃; for 0.5h;	A mixture of 4,6-dichloro-8-fluoro-7-(2-fluoro-6- methoxyphenyl)quinazoline (100 mg, 0.29 mmol), tert-butyl 2,6-diazaspiro[3.4]octane- 6-carboxylate (80 mg, 0.37 mmol), TEA (60 mg, 0.58 mmol) and dichloromethane (5 mL) was stirred at RT for 0.5 h. The mixture was quenched with saturated NaHCO3 solution and partitioned between water and ethyl acetate. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (ethyl acetate/petroleum ether = 1:5) to afford the desired product (120 mg, 80% yield) as white solid.

Reference： [1]Patent: WO2016/164675,2016,A1 .Location in patent: Page/Page column 274; 275

4
[ 885270-86-0 ]
7-fluoro-9-methyl-2-(2-methyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one [ No CAS ]
C₂₆H₃₀N₈O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dimethyl sulfoxide; at 120℃;Sealed tube;	In a sealed tube, 7-fluoro-9-methyl-2-(2-methyl-[l,2,4]triazolo[l,5-b]pyridazin-6-yl)-4H- pyrido[l,2-a]pyrimidin-4-one (Intermediate (VI-3), 30 mg, 0.097 mmol), TEA (34.2 mg, 47 mu, 0.338 mmol, 5 eq.) and <strong>[885270-86-0]tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate</strong> (61.6 mg, 0.290 mmol, 3 eq.) were stirred in DMSO (1.5 ml) at 120C over the night. The precipitating product was filtered and triturated with diethylether. The isolated solid was then treated following the General Procedure 1 for Boc deprotection to afford the product 7-(2,7-diazaspiro[3.4]octan-2-yl)-9-methyl-2-(2-methyl-[l,2,4]triazolo[l,5- b]pyridazin-6-yl)pyrido[l,2-a]pyrimidin-4-one;2,2,2-trifluoroacetic acid (2.5mg, 0.005 mmol, 34.8 % yield) as a brown solid. MS m/z 403.2 [M+H]+.

Reference： [1]Patent: WO2016/184832,2016,A1 .Location in patent: Page/Page column 67

5
[ 885270-86-0 ]
C₁₃H₁₅F₃N₂O [ No CAS ]

Reference： [1]Patent: WO2017/1660,2017,A1

6
[ 885270-86-0 ]
C₂₀H₁₈F₃N₃O [ No CAS ]

Reference： [1]Patent: WO2017/1660,2017,A1

7
[ 885270-86-0 ]
C₂₀H₂₂F₃N₃O [ No CAS ]

Reference： [1]Patent: WO2017/1660,2017,A1

8
[ 885270-86-0 ]
C₃₀H₂₉ClF₃N₅O₂ [ No CAS ]

Reference： [1]Patent: WO2017/1660,2017,A1

9
[ 407-14-7 ]
[ 885270-86-0 ]
C₁₈H₂₃F₃N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 100℃; for 2h;Inert atmosphere; Schlenk technique;	Preparation of intermediate BT 5 In a Shlenck reactor, a solution of <strong>[885270-86-0]6-Boc-2,6-diazaspiro[3.4]octane</strong> (CAS [885270-86- 0], 0.5g, 2.36 mmol), l-Bromo-4-(trifluoromethoxy)benzene (CAS [407-14-7], 525 mu, 3.53 mmol) and sodium terbutoxide (0.453 g, 4.71 mmol) in 1,4-dioxane (25 mL) was purged with N2. Then Palladium (II) acetate (52.9 mg, 0.236 mmol) and Xantphos (0.136 g, 0.236 mmol) were added, the mixture was purged again with N2 and stirred at 10 100C for 2h. The mixture was combined filtered on a pad of Celite. The cake was washed with EtOAc and the fitlrate was evaporated in vacuo to give 1.2 g as a brown solid. The residue was purified by preparative LC (irregular SiOH, 15-40 muiotaeta, 50 g, Merck, dry loading (Celite), mobile phase gradient: from Heptane/EtOAc from 95/5 to 60/40) to give 0.756 g of intermediate BT as off-white solid (80%).

Reference： [1]Patent: WO2017/1660,2017,A1 .Location in patent: Page/Page column 92

10
[ 885270-86-0 ]
[ 5399-92-8 ]
tert-butyl 2-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1 .Location in patent: Page/Page column 99

11
[ 885270-86-0 ]
[ 5399-92-8 ]
tert-butyl 2-[2-(2,2,2-trifluoroethyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1

12
[ 885270-86-0 ]
tert-butyl 2-[(2-cyano-1H-indol-5-yl)methyl]-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1

13
[ 885270-86-0 ]
5-(2,6-diazaspiro[3.4]oct-2-ylmethyl)-1H-indole-2-carbonitrile dihydrochloride [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1

14
[ 885270-86-0 ]
5-formyl-4-methyl-1H-indole-2-carbonitrile [ No CAS ]
tert-butyl 2-[(2-cyano-4-methyl-1H-indol-5-yl)methyl]-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1 .Location in patent: Page/Page column 122; 123

15
[ 885270-86-0 ]
5-formyl-4-methyl-1H-indole-2-carbonitrile [ No CAS ]
5-(2,6-diazaspiro[3.4]oct-2-ylmethyl)-4-methyl-1H-indole-2-carbonitrile hydrochloride [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1

16
[ 885270-86-0 ]
tert-butyl 2-cyano-5-bromomethyl-1H-1-indole-1-carboxylate [ No CAS ]
tert-butyl 5-[6-(tert-butoxycarbonyl)-2,6-diazaspiro[3.4]oct-2-yl]methyl}-2-cyano-1H-indole-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1 .Location in patent: Page/Page column 117; 118

17
[ 885270-86-0 ]
tert-butyl 6-(bromomethyl)-2-cyano-1H-indole-1-carboxylate [ No CAS ]
tert-butyl 6-[6-(tert-butoxycarbonyl)-2,6-diazaspiro[3.4]oct-2-yl]methyl}-2-cyano-1H-indole-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2017/207387,2017,A1 .Location in patent: Page/Page column 120; 121

18
[ 827-01-0 ]
[ 885270-86-0 ]
C₂₀H₂₆ClN₃O₂ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 6002 - 6017

19
[ 885270-86-0 ]
C₁₅H₁₈ClN₃ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 6002 - 6017

20
[ 885270-86-0 ]
C₃₁H₃₆ClN₅O₃ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 6002 - 6017

21
[ 885270-86-0 ]
(S)-2-amino-1-(2-((5-chloro-1H-indol-3-yl)methyl)-2,6-diazaspiro[3.4]octan-6-yl)-3-(1H-indol-3-yl)propan-1-one [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 6002 - 6017

22
[ 885270-86-0 ]
2,7-diazaspiro[3.4]octane-2-carboxylic acid benzyl ester [ No CAS ]

Reference： [1]Patent: CN109928971,2019,A

23
[ 885270-86-0 ]
7-methanesulfonyl-2,7-diazaspiro[3.4]octane-2-carboxylic acid benzyl ester [ No CAS ]

Reference： [1]Patent: CN109928971,2019,A

24
[ 885270-86-0 ]
7-methanesulfonyl-2,7-diazaspiro[3.4]octane [ No CAS ]

Reference： [1]Patent: CN109928971,2019,A

25
[ 885270-86-0 ]
[ 501-53-1 ]
O₂-benzyl O₇-tert-butyl 2,7-diazaspiro[3.4]octane-2,7-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With triethylamine; In dichloromethane; at 0 - 20℃; for 21h;	At 0 C, Triethylamine (2.1 mL, 15.0 mmol) with benzyl chloroformate (2.2 mL, 15.0 mmol) Adding to a solution of <strong>[885270-86-0]2,7-diazaspiro[3.4]octane-7-carboxylic acid tert-butyl ester</strong> (1.6 g, 7.5 mmol) in dichloromethane (20 mL) the reaction was carried out at room temperature for 21 hours. Water (5 mL) was added, and the organic phase was washed with a saturated sodium chloride solution (5 mL×2). Dry over anhydrous sodium sulfate and concentrate by suction filtration. The residue was subjected to silica gel column chromatography [petroleum ether/ethyl acetate (v / v) = 3 / 1] purification, The title compound (1.8 g, yield 69%)

Reference： [1]Patent: CN109928971,2019,A .Location in patent: Paragraph 0213; 0218; 0219; 0220; 0221

26
[ 1359655-84-7 ]
[ 885270-86-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With sodium hydrogencarbonate; In water; at 20℃; for 1.5h;	Sodium bicarbonate (10.0 g, 119 mmol)Add to a solution of 2,7-diazaspiro[3.4]octane-7-carboxylic acid tert-butyl ester oxalate (3.0 g, 9.9 mmol) in water (10 mL)The reaction was carried out at room temperature for 1.5 hours. Extracted with dichloromethane/methanol (v/v = 9/1, 80 mL x 3),The combined organic phases were washed with a saturated sodium chloride solution (50 mL×2). Dry over anhydrous sodium sulfate and concentrate by suction filtration.The title compound was obtained (1.68 g, yield 80%). It is a yellow oil.

Reference： [1]Patent: CN109928971,2019,A .Location in patent: Paragraph 0213; 0215; 0216; 0217

27
[ 885270-86-0 ]
[ 124-63-0 ]
tert-butyl 2-(methylsulfonyl)-2,6-diazaspiro[3.4]octane-6-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine;	Commercially available /er/-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate was treated with MsCl in the presence of TEA to afford tert- butyl 2-(methylsulfonyl)-2,6- diazaspiro[3.4]octane-6-carboxylate which was next treated with TFA in DCM (80% v/v) to afford Amine Intermediate 15 which was used without purification.

Reference： [1]Patent: WO2019/177997,2019,A1 .Location in patent: Paragraph 00247

28
[ 885270-86-0 ]
2-(methylsulfonyl)-2,6-diazaspiro[3.4]octane trifluoroacetate [ No CAS ]

Reference： [1]Patent: WO2019/177997,2019,A1

29
[ 885270-86-0 ]
2-((2-ethyl-5-(6-(3-hydroxyazetidine-1-carbonyl)-2,6-diazaspiro[3.4]octan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 15 2-((2-ethyl-5-(6-(3-hydroxyazetidine-1-carbonyl)-2,6-diazaspiro[3.4]octan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile (Compound 15) Starting from intermediate 1 (100 mg, 0.22 mmol) and proceeding in analogy to preparation Example 11, using <strong>[885270-86-0]tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate</strong> to afford the title Compound 15 (70 mg, 55% over 4 steps) as a pale brown solid. 1H NMR (400 MHz, CDCl3) delta 8.51-8.50 (d, J=7.6 Hz, 1H), 8.16-8.13(m, 2H), 7.18-7.14(m, 2H), 6.20(d, J=7.6 Hz, 1H), 5.89(s, 1H), 4.62-4.59(m, 1H), 4.28-4.14(m, 2H), 3.96-3.89(m, 4H), 3.86-3.83(m, 2H), 3.57(s, 3H), 3.44(t, J=6.8 Hz, 2H), 2.77(q, J=7.6 Hz, 2H), 2.15(t, J=6.8 Hz, 2H), 1.43-1.23(m, 5H). LC-MS: m/z=587.3 [M+H]+.

Reference： [1]Patent: US2019/367515,2019,A1

30
[ 885270-86-0 ]
5-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-sulfonyl chloride [ No CAS ]
5-((2,6-diazaspiro[3.4]octan-2-yl)sulfonyl)-N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-4H-1,2,4-triazol-3-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25%		General procedure: To a stirred solution of 6-(2-fluoroethyl)-2,6-diazaspiro[3.4]octane (Intermediate X11) (0.107 g, 0.640 mmol) and Et3N (0.089 mL, 0.640 mmol) in DCM (2 mL) was added 5-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-1-((2-(trimethylsilyl)ethoxy)- methyl)-1H-1,2,4-triazole-3-sulfonyl chloride (Intermediate B4) (0.205 g, 0.438 mmol) in DCM (4 mL). The reaction was stirred at RT for 90 min then concentrated in vacuo. The residue was redissolved in 4 M HCl in dioxane (3 mL) and stirred for 16 h. The reaction mixture was concentrated in vacuo and the crude product was purified by acidic prep HPLC (20-50% MeOH in water) to afford the title compound (23 mg, 11%) as a white solid.LCMS m/z 461.1 (M+H)+(ES+).1H NMR (DMSO-d6) d 13.25 (s, 1H), 9.01 (s, 1H), 6.98 (s, 1H), 4.50 (dt, J = 47.4, 4.8 Hz, 2H), 3.95 - 3.82 (m, 4H), 2.87 - 2.77 (m, 5H), 2.76 - 2.72 (m, 1H), 2.71 - 2.59 (m, 8H), 1.98 (p, J = 7.4 Hz, 4H), 1.88 (t, J = 7.1 Hz, 2H).

Reference： [1]Patent: WO2019/211463,2019,A1 .Location in patent: Page/Page column 476; 477; 492; 493

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P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 885270-86-0 ]

Quality Control of [ 885270-86-0 ]

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Physicochemical Properties

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Lipophilicity

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Water Solubility

Medicinal Chemistry

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Application In Synthesis of [ 885270-86-0 ]

[ 885270-86-0 ] Synthesis Path-Downstream 1~30

Similar Product of [ 885270-86-0 ]

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Amides

Related Parent Nucleus of [ 885270-86-0 ]

Aliphatic Heterocycles

Azetidines

Pyrrolidines

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Prevention

Response

Storage

Disposal

Physical hazards

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Inquiry

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[ 885270-86-0 ]

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[ 885270-86-0 ]

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[ 885270-86-0 ]