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[ CAS No. 250275-15-1 ]

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Chemical Structure| 250275-15-1
Chemical Structure| 250275-15-1
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CAS No. :250275-15-1 MDL No. :MFCD04116224
Formula : C11H20N2O2 Boiling Point : 295.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :212.29 g/mol Pubchem ID :1514452
Synonyms :

Safety of [ 250275-15-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 250275-15-1 ]

  • Upstream synthesis route of [ 250275-15-1 ]
  • Downstream synthetic route of [ 250275-15-1 ]

[ 250275-15-1 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 370879-56-4 ]
  • [ 250275-15-1 ]
YieldReaction ConditionsOperation in experiment
66% With 10 wt% Pd(OH)2 on carbon; hydrogen In methanol at 60℃; To a solution of (3 aR,6a5)-tert-butyl 5 -benzylhexahydropyrrolo [3 ,4-c]pyrrole-2( 1 H)carboxylate (5 g, 16.5 mmol) in MeOH (50 mL) was added Pd(OH)2/C (10 percent) (0.5 g). The reaction mixture was stirred at 60 °C overnight under an H2 atmosphere at 60 psi and then cooled to ambient temperature. The reaction mixture was filtered through Celite and the filtrate was evaporated to provide (3 aR,6aS)-tert-butyl hexahydropyrrolo [3 ,4-c]pyrrole-2( 1 H)-carboxylate get as a colorless oil (2.3 g, 66 percent).
66% With 10% palladium hydroxide on charcoal; hydrogen In methanol at 60℃; Step 4 To a solution of (3aR,6aS)-tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(lH)- carboxylate (5 g, 16.5 mmol) in methanol (50 mL) was added Pd(OH)2/C (10 percent) (0.5 g). The mixture was stirred at 60 °C overnight under hydrogen atmosphere at 60 psi before cooling to ambient temperature. The reaction mixture was filtered by celite. The filtrated solution was evaporated under vacuum to obtain (3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(lH)- carboxylate as a colorless oil (2.3 g, 66 percent).
Reference: [1] Patent: US2002/19388, 2002, A1,
[2] Patent: WO2015/120049, 2015, A1, . Location in patent: Page/Page column 139; 140
[3] Patent: WO2016/191172, 2016, A1, . Location in patent: Page/Page column 86
[4] Patent: US2009/281118, 2009, A1, . Location in patent: Page/Page column 10
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4126 - 4141
[6] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5620 - 5636
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  • [ 172739-04-7 ]
  • [ 250275-15-1 ]
Reference: [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5620 - 5636
[2] Patent: WO2015/120049, 2015, A1,
[3] Patent: WO2016/191172, 2016, A1,
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  • [ 370879-53-1 ]
  • [ 250275-15-1 ]
Reference: [1] Patent: WO2015/120049, 2015, A1,
[2] Patent: WO2016/191172, 2016, A1,
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  • [ 24424-99-5 ]
  • [ 250275-15-1 ]
Reference: [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5620 - 5636
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