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CAS No. : | 886496-88-4 | MDL No. : | MFCD05864310 |
Formula : | C7H4BrF3O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GVPNWQKCKBFPBG-UHFFFAOYSA-N |
M.W : | 257.01 | Pubchem ID : | 2757194 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With potassium carbonate In acetone for 10 h; | Intermediate 5 : 2-Bromo-4-methoxy- 1 -(trifluoromethoxy)benzene; A mixture of 3-bromo-4-(trifluoromethoxy)phenol (2.0 g, 7.8 mmol), K2CO3 (1.62 g, 1 1.72 mmol), and MeI (2.43 mL, 39.06 mmol) in acetone (13 mL) was stirred for 1O h. After removal of acetone under reduced pressure, the crude was diluted with CH2Cl2, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on SiO2 using gradient of 0 to 50percent EtOAc in hexanes to provide the example intermediate (2.10 g, 99percent). |
93% | With potassium carbonate In acetone for 2 h; Heating / reflux | To a stirred suspension of 3-Bromo-4-trifluoromethoxy-phenol (20.6 g, 82.6 mol) and potassium carbonate (46.3 g, 330.4 mmol) in acetone (600 ml) was added drop-wise iodomethane (46.9 g, 330.4 mmol) under an atmosphere of nitrogen. The resulting mixture was stirred at reflux for 2 hours. The reaction mixture was cooled to room temperature then filtered and the filtrate was evaporated in vacuo to afford the title compound as a colourless oil (19.8 g, 93percent). 1HNMR (CDCI3): 3.73 (s, 3H), 6.78 (dd, 1 H), 7.08 (d, 1 H), 7.18 (dd, 1 H |
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