Home Cart 0 Sign in  

[ CAS No. 886497-81-0 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 886497-81-0
Chemical Structure| 886497-81-0
Structure of 886497-81-0 * Storage: {[proInfo.prStorage]}

Quality Control of [ 886497-81-0 ]

Related Doc. of [ 886497-81-0 ]

SDS
Alternatived Products of [ 886497-81-0 ]
Alternatived Products of [ 886497-81-0 ]

Product Details of [ 886497-81-0 ]

CAS No. :886497-81-0 MDL No. :MFCD04115886
Formula : C8H4F4O2 Boiling Point : 200.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :208.11 g/mol Pubchem ID :2783324
Synonyms :

Safety of [ 886497-81-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886497-81-0 ]

  • Upstream synthesis route of [ 886497-81-0 ]
  • Downstream synthetic route of [ 886497-81-0 ]

[ 886497-81-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 352-67-0 ]
  • [ 68-12-2 ]
  • [ 886497-81-0 ]
YieldReaction ConditionsOperation in experiment
53%
Stage #1: With tert.-butyl lithium In tetrahydrofuran; pentane at -70℃; for 0.25 h; dry ice bath
Stage #2: at -70 - 20℃; for 0.5 h;
Stage #3: With water; ammonium chloride In tetrahydrofuran; pentane at 20℃;
EXAMPLE 49 3-Trifluoromethoxy-10-methyl-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine; a) 2-Fluoro-5-trifluoromethoxy-benzaldehyde; A solution of 1-fluoro-4-trifluoromethoxy-benzene (21.0 g, 117 mmol) in THF (233 ml) was cooled to <-70° C. Tert.-butyllithium (86 ml of a 1.5 molar solution in pentane, 129 mmol) was added at such a rate that temperature was kept <-70° C. Stirring in the dry ice bath was continued for 15 min, then DMF (11.6 ml, 150 mmol) was added dropwise keeping temperature <-70° C. After 30 min the reaction mixture was allowed to reach rt, quenched with saturated NH4Cl solution and extracted with ether. The organic phase was washed with brine, concentrated and chromatographed (SiO2, heptane:ethyl acetate=100:0 to 80:2). The title compound (11.0 g, 53percent) was obtained as a light yellow oil. 1H-NMR (300 MHz, DMSO): δ=7.60 (t, J=9.2 Hz, 1H), 7.75-7.85 (m, 2H), 10.20 (s, 1H).
Reference: [1] Patent: US2006/128691, 2006, A1, . Location in patent: Page/Page column 23-24
Historical Records

Related Functional Groups of
[ 886497-81-0 ]

Trifluoromethyls

Chemical Structure| 52771-21-8

[ 52771-21-8 ]

3-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 659-28-9

[ 659-28-9 ]

4-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 886497-85-4

[ 886497-85-4 ]

2-Fluoro-5-(trifluoromethoxy)benzoic acid

Similarity: 0.80

Chemical Structure| 170141-63-6

[ 170141-63-6 ]

3'-(Trifluoromethoxy)acetophenone

Similarity: 0.77

Chemical Structure| 93249-62-8

[ 93249-62-8 ]

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde

Similarity: 0.77

Fluorinated Building Blocks

Chemical Structure| 1214333-68-2

[ 1214333-68-2 ]

2-(Difluoromethoxy)-6-fluorobenzaldehyde

Similarity: 0.87

Chemical Structure| 331-64-6

[ 331-64-6 ]

2-Fluoro-4-methoxybenzaldehyde

Similarity: 0.81

Chemical Structure| 52771-21-8

[ 52771-21-8 ]

3-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 659-28-9

[ 659-28-9 ]

4-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 886497-85-4

[ 886497-85-4 ]

2-Fluoro-5-(trifluoromethoxy)benzoic acid

Similarity: 0.80

Aryls

Chemical Structure| 1214333-68-2

[ 1214333-68-2 ]

2-(Difluoromethoxy)-6-fluorobenzaldehyde

Similarity: 0.87

Chemical Structure| 331-64-6

[ 331-64-6 ]

2-Fluoro-4-methoxybenzaldehyde

Similarity: 0.81

Chemical Structure| 52771-21-8

[ 52771-21-8 ]

3-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 659-28-9

[ 659-28-9 ]

4-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 886497-85-4

[ 886497-85-4 ]

2-Fluoro-5-(trifluoromethoxy)benzoic acid

Similarity: 0.80

Ethers

Chemical Structure| 1214333-68-2

[ 1214333-68-2 ]

2-(Difluoromethoxy)-6-fluorobenzaldehyde

Similarity: 0.87

Chemical Structure| 331-64-6

[ 331-64-6 ]

2-Fluoro-4-methoxybenzaldehyde

Similarity: 0.81

Chemical Structure| 52771-21-8

[ 52771-21-8 ]

3-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 659-28-9

[ 659-28-9 ]

4-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 886497-85-4

[ 886497-85-4 ]

2-Fluoro-5-(trifluoromethoxy)benzoic acid

Similarity: 0.80

Aldehydes

Chemical Structure| 1214333-68-2

[ 1214333-68-2 ]

2-(Difluoromethoxy)-6-fluorobenzaldehyde

Similarity: 0.87

Chemical Structure| 331-64-6

[ 331-64-6 ]

2-Fluoro-4-methoxybenzaldehyde

Similarity: 0.81

Chemical Structure| 52771-21-8

[ 52771-21-8 ]

3-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 659-28-9

[ 659-28-9 ]

4-(Trifluoromethoxy)benzaldehyde

Similarity: 0.81

Chemical Structure| 699016-24-5

[ 699016-24-5 ]

3-Fluoro-5-methoxybenzaldehyde

Similarity: 0.80