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Chemical Structure| 886497-89-8 Chemical Structure| 886497-89-8

Structure of 886497-89-8

Chemical Structure| 886497-89-8

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Product Details of [ 886497-89-8 ]

CAS No. :886497-89-8
Formula : C8H3ClF4O2
M.W : 242.56
SMILES Code : O=C(Cl)C1=CC(OC(F)(F)F)=CC=C1F
MDL No. :MFCD04115888

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Application In Synthesis of [ 886497-89-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886497-89-8 ]

[ 886497-89-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 886497-89-8 ]
  • [ 100137-47-1 ]
  • 4-[[2-fluoro-5-(trifluoromethoxy)benzoyl]amino]pyridine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 0 - 20℃; for 16h; To a solution of <strong>[100137-47-1]4-aminopyridine-2-carboxamide</strong> (565 mg, 4.12 mmol) and DIEA (1.33 g, 10.3 mmol) in NMP (10 mL) at 0 C was added a solution of 2-fluoro-5-(trifluoromethoxy)benzoyl chloride (1.00 g, 4.123 mmol) in dichloromethane (5 mL) dropwise. The reaction was allowed to warm to room temperature and stirred for 16 hours. The reaction mixture was partitioned between ethyl acetate and water, and the layers separated. The organic layer was dried over Na2SC>4, filtered and concentrated in vacuo to obtain 4-[[2-fluoro-5-(trifluoromethoxy)benzoyl]amino]pyridine-2-carboxamide (850 mg, 60%). ESI-MS m/z calc. 343.05, found 344.1 (M+l)+; retention time (Method B): 0.51 minutes (3 minute run).
 

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