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Chemical Structure| 888327-38-6 Chemical Structure| 888327-38-6

Structure of 888327-38-6

Chemical Structure| 888327-38-6

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Product Details of [ 888327-38-6 ]

CAS No. :888327-38-6
Formula : C6H2Cl2F3N
M.W : 215.99
SMILES Code : FC(F)(F)C1=CN=C(Cl)C=C1Cl
MDL No. :MFCD14525480
InChI Key :HQEZKTVEZYMLRK-UHFFFAOYSA-N
Pubchem ID :45790941

Safety of [ 888327-38-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 888327-38-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 888327-38-6 ]

[ 888327-38-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 888327-38-6 ]
  • [ 89830-98-8 ]
  • 2-chloro-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With potassium carbonate; In N,N-dimethyl-formamide; at 70℃; Into a 50-mL round-bottom flask purged with nitrogen, was placed a solution of 2,4- dichloro-5-(trifluoromethyl)pyridine (800 mg, 3.7 mmol) in DMF (2 mL), 4-cyclopropyl-1H- imidazole (482 mg, 4.4 mmol) and K2C03 (1.53 g, 11.1 mmol). The resulting mixture was stirred at 70°C overnight. Solvent was removed in vacuo. Purification of the crude product on a silica gel column with 30percent EtOAc/PE afforded 360 mg (38percent) of 2-chloro-4-(4-cyclopropyl- 1 H-imidazol- 1 -yl)-5 -(trifluoromethyl)pyridine as a yellow solid.
 

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