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Chemical Structure| 890051-43-1 Chemical Structure| 890051-43-1

Structure of 890051-43-1

Chemical Structure| 890051-43-1

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Product Details of [ 890051-43-1 ]

CAS No. :890051-43-1
Formula : C15H13IO3
M.W : 368.17
SMILES Code : O=C(OC)C1=CC=CC(COC2=CC=C(I)C=C2)=C1
MDL No. :MFCD28023859

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Application In Synthesis of [ 890051-43-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 890051-43-1 ]

[ 890051-43-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 890051-43-1 ]
  • [ 126617-98-9 ]
  • 3-(2'-methoxymethyl-biphenyl-4-yloxymethyl)-benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
A solution of 3-(4-iodo-phenoxymethyl)-benzoic acid methyl ester (of intermediate 1; 37 mg, 0.1 mmol) in dioxane (2 mL) was degassed with nitrogen and then added to a reaction vial containing <strong>[126617-98-9]2-methoxymethylphenylboronic acid</strong> (available from Apollo Scientific Ltd., Stockport, UK). The solution was sonicated and degassed and a solution of sodium hydroxide (4 M, 0.2 mL) was added, followed by bis(tri-cyclo-hexylphosphine)palladium (available from Strem Chemicals, Inc., Newburyport, Mass.; 0.005 mmol) was added. The mixture was degassed and then heated in a microwave oven at 170 degrees for 25 min. The reaction mixture was filtered through silica and the silica washed with dioxane (1 mL), and dimethylacetamide (1 mL). 1 M HCl was added until a solid formed. The vial was centrifuged and the solvent was removed. The crude product was washed with water and centrifuged again for 5 min. The water was decanted and the solid was dried in a vacuum oven at 50 degrees to give 3-(2'-methoxymethyl-biphenyl-4-yloxymethyl)-benzoic acid. Mass spectrum MH+=349.
 

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