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Chemical Structure| 89088-51-7 Chemical Structure| 89088-51-7

Structure of 89088-51-7

Chemical Structure| 89088-51-7

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Product Details of [ 89088-51-7 ]

CAS No. :89088-51-7
Formula : C10H12BrN3
M.W : 254.13
SMILES Code : CN1N=C(N2C(C)=CC=C2C)C=C1Br
MDL No. :MFCD27955953

Safety of [ 89088-51-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 89088-51-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89088-51-7 ]

[ 89088-51-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 454482-11-2 ]
  • [ 89088-51-7 ]
  • 4-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazol-5-yl]-1-methyl-1,2,3,6-tetrahydropyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
72 mg With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; In N,N-dimethyl-formamide; at 80℃; for 1h;Inert atmosphere; Preparation Example 45 Under argon atmosphere, to a mixture of 5-bromo-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (100 mg), <strong>[454482-11-2]1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine</strong> (105 mg), and N,N-dimethylformamide (2 mL) were added a 1,1'-bis(diphenylphosphino)ferrocene-palladium (II) dichloride-dichloromethane complex (32 mg), and cesium carbonate (256 mg), followed by reacting them at 80° C. for 1 hour. After leaving to be cooled, ethyl acetate was added thereto, and the mixture was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by silica gel column chromatography (eluent; chloroform:methanol=1:0-9:1) to obtain 4-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazol-5-yl]-1-methyl-1,2,3,6-tetrahydropyridine (72 mg) as a brown oily substance.
 

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