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Chemical Structure| 89250-15-7 Chemical Structure| 89250-15-7

Structure of 89250-15-7

Chemical Structure| 89250-15-7

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Product Details of [ 89250-15-7 ]

CAS No. :89250-15-7
Formula : C10H11N3
M.W : 173.21
SMILES Code : NC1=CC=C(C2=CN=CN2C)C=C1
MDL No. :MFCD18375273

Safety of [ 89250-15-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 89250-15-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89250-15-7 ]

[ 89250-15-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 61278-68-0 ]
  • [ 89250-15-7 ]
YieldReaction ConditionsOperation in experiment
90% In MeOH on palladium; pyrographite; (b) 5-(4-amino-phenyl)-1-methyl-imidazole Prepared by hydrogenation of 1-methyl-5-(4-nitro-phenyl)-imidazole in MeOH on palladium/charcoal (10%) at 20 C. and 3.5 bar. Yield (crude): 90% of theory; Melting point: 130 C.
  • 2
  • [ 4428-98-2 ]
  • [ 89250-15-7 ]
  • [ 89250-49-7 ]
  • 3
  • [ 89250-15-7 ]
  • [ 103298-43-7 ]
  • 4
  • [ 774238-44-7 ]
  • [ 89250-15-7 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In water; dimethyl sulfoxide; at 120℃; for 2h; Reference Example 31 4-(3-Methyl-3H-imidazol-4-yl)phenylamine An aqueous solution of 20% sodium hydroxide was added to a DMSO solution (20 ml) of N-[4-(3-methyl-3H-imidazol-4-yl)phenyl]acetamide (708 mg), followed by stirring at 120C for 2 hours. After cooling, the reaction solution was concentrated under reduced pressure, and to the thus obtained residue was added water and extracted with chloroform. The organic layer was washed with water and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, the thus obtained residue was purified by silica gel column chromatography, and the fraction obtained from the elude of dichloromethane:methanol = 10:1 was concentrated under reduced pressure. The thus obtained product was washed with diisopropyl ether and then dried to obtain the title compound (480 mg) as a crystalline solid. 1H-NMR (400 MHz, CDCl3) delta: 3.61 (3H, s), 3.80 (2H, br s), 6.73 (2H, d, J=8.1 Hz), 6.99 (1H, s), 7.16 (2H, d, J=8.1 Hz), 7.46 (1H, br s).
  • 5
  • [ 89250-15-7 ]
  • 4-(3-methyl-3H-imidazol-4-yl)phenylhydrazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Reference Example 32 4-(3-Methyl-3H-imidazol-4-yl)phenylhydrazine <strong>[89250-15-7]4-(3-Methyl-3H-imidazol-4-yl)phenylamine</strong> (430 mg) was dissolved in concentrated hydrochloric acid (4.0 ml), water (2.0 ml) and THF (2.0 ml), and an aqueous solution (2 ml) of sodium nitrite (206 mg) was added dropwise to the mixture under ice-cooling. After stirring for 40 minutes, a concentrated hydrochloric acid solution (3 ml) of tin chloride dihydrate (1.34 g) was added to the mixture, followed by stirring at room temperature for 2 hours. The reaction solution was alkalified by adding aqueous ammonia (28%), chloroform:methanol = 10:1 solution was added to the mixture and then filtered through celite. An organic layer of the filtrate was dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the title compound (289 mg) as a yellow solid. 1H-NMR (400 MHz, CDCl3) delta: 3.24 (2H, br s), 3.62 (3H, s), 5.34 (1H, br s), 6.88 (2H, d, J=8.8 Hz), 7.01 (1H, s), 7.24 (2H, d, J=8.8 Hz), 7.47 (1H, s).
 

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