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Chemical Structure| 89407-43-2 Chemical Structure| 89407-43-2

Structure of 89407-43-2

Chemical Structure| 89407-43-2

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Product Details of [ 89407-43-2 ]

CAS No. :89407-43-2
Formula : C9H9BrO3
M.W : 245.07
SMILES Code : O=C(O)C1=CC=C(Br)C=C1OCC
MDL No. :MFCD11651850

Safety of [ 89407-43-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 89407-43-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89407-43-2 ]

[ 89407-43-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 89407-43-2 ]
  • [ 1791-13-5 ]
  • (S)-di-tert-butyl 2-(4-bromo-2-ethoxybenzamido)succinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
52% With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20℃; for 2h; Step 1 : (S)-di-tert-butyl 2-(4-bromo- -ethoxybenzamido)succinate To a solution containing (S)-di-tert-butyl 2-aminosuccinate, Hydrochloride (6.90 g, 24.48 mmol) and 4-bromo-2-ethoxybenzoic acid (5 g, 20.40 mmol) in DCM (40 mL) at RT was added HATU (9.31 g, 24.48 mmol) followed by DIPEA (10.69 mL, 61 .2 mmol). The reaction mixture was stirred at RT for 2h. The reaction mixture was diluted with NH4CI aq. and extracted with DCM. The combined organic layer was dried over MgS04, filtered and concentrated onto Celite. Purification by Si (0-100% EtOAc/Hex) afforded the title compound as a pale yellow oil. (5.2 g, 52 % yield). MS (m/z) 472.2 (M)+
 

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