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Chemical Structure| 89581-87-3 Chemical Structure| 89581-87-3

Structure of 89581-87-3

Chemical Structure| 89581-87-3

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Product Details of [ 89581-87-3 ]

CAS No. :89581-87-3
Formula : C6H5Cl2N3O
M.W : 206.03
SMILES Code : CC(NC1=NC(Cl)=NC(Cl)=C1)=O
MDL No. :MFCD01346932

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Application In Synthesis of [ 89581-87-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89581-87-3 ]

[ 89581-87-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22237-13-4 ]
  • [ 89581-87-3 ]
  • [ 1422527-97-6 ]
YieldReaction ConditionsOperation in experiment
76% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,2-dimethoxyethane; water; at 110℃; for 12h; General procedure: A mixture of the amide 2 (0.43 mmol), boronic acids 3 (1.3 mmol), Pd(PPh3)4 (0.043 mmol), and Na2CO3 (2.1 mmol) in 5 mL of a mixture of DME/H20 (3:1) in coated Kimble vials was stirred with orbital stirring at 110 C for 12 h. The resulting mixture was concentrated in vacuo and then ethyl acetate was added. This solution was washed with water and NaOH 1 N to remove the acid boronic excess. The organic layer was collected, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography or preparative method on silica gel.
 

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