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Chemical Structure| 897030-99-8 Chemical Structure| 897030-99-8

Structure of 897030-99-8

Chemical Structure| 897030-99-8

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Product Details of [ 897030-99-8 ]

CAS No. :897030-99-8
Formula : C5H5ClIN3
M.W : 269.47
SMILES Code : CC1=NC(N)=NC(Cl)=C1I
MDL No. :MFCD12024467

Safety of [ 897030-99-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 897030-99-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 897030-99-8 ]

[ 897030-99-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 897030-99-8 ]
  • [ 33024-60-1 ]
  • [ 1220812-03-2 ]
YieldReaction ConditionsOperation in experiment
51.7% With triethylamine; In ethanol; water; for 72h;Reflux; Scheme B; [00196] To a suspension of 4-chloro-5-iodo-6-methylpyrimidin-2-amine (16.0 g, 59.3 mmol) in EtOH (200 mL) and H2O (250 mL) was added triethylamine ( 30.0 mL, 207.5 mmol) and 4-aminotetrahydropyran HCl salt (9.75g, 71.2 mmol) successively. The reaction was heated to reflux, stirred for 72 h, and then cooled to RT. About 80percent of the solvent was evaporated under reduced pressure. The mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to afford the crude product. The product was purified by a flash chromatography (50percent ethyl acetate/hexanes to 100percent ethyl acetate) to afford 5-iodo-6-methyl-//-(tetrahydro-2H-pyran- 4-yl)pyrimidine-2,4-diamine as a light yellow crystal (yield: 10.23g, 51.7percent). LC/MS: calculated for Ci0Hi5IN4O (334.03); found: 335.08 (MH+). HPLC analytical purity: > 99.0 percent.
 

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