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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 89938-06-7 Chemical Structure| 89938-06-7

Structure of 89938-06-7

Chemical Structure| 89938-06-7

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Product Details of [ 89938-06-7 ]

CAS No. :89938-06-7
Formula : C7H8Cl2N2
M.W : 191.06
SMILES Code : CC(C1=C(Cl)N=CN=C1Cl)C
MDL No. :MFCD18844158
InChI Key :WGEQNVJAKYNYTM-UHFFFAOYSA-N
Pubchem ID :22138881

Safety of [ 89938-06-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 89938-06-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89938-06-7 ]

[ 89938-06-7 ] Synthesis Path-Downstream   1~6

  • 3
  • [ 90345-37-2 ]
  • [ 89938-06-7 ]
YieldReaction ConditionsOperation in experiment
With N,N-dimethyl-aniline; trichlorophosphate; at 100.0℃; for 3.0h; Method QQ Preparation of 5-Alkyl-4,6-dichloropyrimidine or 5-Alkoxy-4-chloropyrimidine To a 5-alkyl-4,6-dihydroxypyrimidine or a 5-alkoxy-4-hydroxypyrimidine (1.0 eq) were added phosphorus oxychloride (15.0 eq) and NN-dimethylaniline (1.0 eq), and the mixture was heated to 100C for 3 h, and then allowed to cool. The resulting solution was poured onto ice, and the mixture was extracted with dichloromethane. The organic extracts were treated with anhydrous magnesium sulfate, filtered, and evaporated to afford a 5-alkyl-4,6-dichloropyrimidine or a 5- alkoxy-4-chloropyrimidine of sufficient purity for immediate conversion to a 5- alkyl-4-N-alkylamino-6-chloropyrimidine or a 5-alkoxy-4-N-alkylaminopyrimidine.
  • 4
  • [ 284486-57-3 ]
  • [ 89938-06-7 ]
  • C23H31ClN4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 3-methyl-N-(3-methylbutyl)-1-butanamine; In ethanol; at 120.0℃; for 48.0h; Method RR Preparation of S-Alk(at)-4-N alkylamino-6-chloropyrimidine or 5-Alkoxy-4-N-alkylaminopylimidine To a solution of a 5-alkyl-4,6-dichloropyrimidine or a 5-alkoxy-4- chloropyrimidine (1.0 eq) in ethanol were added an alkyl amine (1.2 eq, typically L- 4-(N,N dimethylcarbamyloxy)-phenylalanine tert-butyl ester) and diisopropylethylamine (2.0 eq). The mixture was sealed in a pressure tube and heated to 120C for 48 h, at which point TLC indicated consumption of the 5-alkyl- 4,6-dichloropyrimidine or the 5-alkoxy-4-chloropyrimidine. The mixture was evaporated, and the residue was partitioned between ethyl acetate and pH = 4.5 citrate buffer. The organic extracts were washed with saturated sodium chloride, treated with anhydrous magnesium sulfate, filtered, and evaporated. The residue was purified by chromatography on silica gel using ethyl acetate and hexanes to afford a pure 5-alkyl-4-N-alkylamino-6-chloropyrimidine or 5-alkoxy-4-N- alkylaminopyrimidine.
  • 5
  • C11H20O2 [ No CAS ]
  • [ 89938-06-7 ]
  • C25H34FN3O4S [ No CAS ]
  • 6
  • C11H20O2 [ No CAS ]
  • [ 89938-06-7 ]
  • C18H27ClN2O2 [ No CAS ]
 

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