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Chemical Structure| 90345-37-2 Chemical Structure| 90345-37-2

Structure of 90345-37-2

Chemical Structure| 90345-37-2

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Product Details of [ 90345-37-2 ]

CAS No. :90345-37-2
Formula : C7H10N2O2
M.W : 154.17
SMILES Code : O=C1NC=NC(O)=C1C(C)C
MDL No. :MFCD22690696

Safety of [ 90345-37-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 90345-37-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90345-37-2 ]

[ 90345-37-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 90345-37-2 ]
  • [ 89938-06-7 ]
YieldReaction ConditionsOperation in experiment
With N,N-dimethyl-aniline; trichlorophosphate; at 100.0℃; for 3.0h; Method QQ Preparation of 5-Alkyl-4,6-dichloropyrimidine or 5-Alkoxy-4-chloropyrimidine To a 5-alkyl-4,6-dihydroxypyrimidine or a 5-alkoxy-4-hydroxypyrimidine (1.0 eq) were added phosphorus oxychloride (15.0 eq) and NN-dimethylaniline (1.0 eq), and the mixture was heated to 100C for 3 h, and then allowed to cool. The resulting solution was poured onto ice, and the mixture was extracted with dichloromethane. The organic extracts were treated with anhydrous magnesium sulfate, filtered, and evaporated to afford a 5-alkyl-4,6-dichloropyrimidine or a 5- alkoxy-4-chloropyrimidine of sufficient purity for immediate conversion to a 5- alkyl-4-N-alkylamino-6-chloropyrimidine or a 5-alkoxy-4-N-alkylaminopyrimidine.
 

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