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Chemical Structure| 905710-14-7 Chemical Structure| 905710-14-7

Structure of 905710-14-7

Chemical Structure| 905710-14-7

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Product Details of [ 905710-14-7 ]

CAS No. :905710-14-7
Formula : C14H16BrNO3
M.W : 326.19
SMILES Code : C(=O)(OC(C)(C)C)[N]2C1=CC=C(C=C1C(=C2)CO)Br
MDL No. :MFCD05864710
InChI Key :LPXSZZFLLCBIJX-UHFFFAOYSA-N
Pubchem ID :40428532

Safety of [ 905710-14-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 905710-14-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 905710-14-7 ]

[ 905710-14-7 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 905710-14-7 ]
  • [ 18162-48-6 ]
  • [ 905710-15-8 ]
  • 2
  • [ 325800-39-3 ]
  • [ 905710-14-7 ]
  • 3
  • [ 905710-14-7 ]
  • tert-butyl 5-bromo-3-((1R,2R)-1-(tert-butyldimethylsilyloxy)-3-methoxy-3-oxo-2-phenylpropyl)-1H-indole-1-carboxylate [ No CAS ]
  • 4
  • [ 905710-14-7 ]
  • tert-butyl 5-bromo-3-(1-(tert-butyldimethylsilyloxy)-3-methoxy-3-oxo-2-phenylpropyl)-1H-indole-1-carboxylate [ No CAS ]
  • 5
  • [ 905710-14-7 ]
  • tert-butyl 5-bromo-3-(1-(tert-butyldimethylsilyloxy)-3-methoxy-3-oxo-2-phenylpropyl)-1H-indole-1-carboxylate [ No CAS ]
  • 6
  • [ 905710-14-7 ]
  • tert-butyl 5-bromo-3-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-methoxy-3-oxo-2-phenylpropyl)-1H-indole-1-carboxylate [ No CAS ]
  • 7
  • [ 905710-14-7 ]
  • tert-butyl 5-bromo-3-((6-hydroxybenzo[d][1,3]dioxol-5-yl)-methyl)-1H-indole-1-carboxylate [ No CAS ]
  • 8
  • [ 905710-14-7 ]
  • [ 533-31-3 ]
  • tert-butyl 3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-5-bromo-1H-indole-1-carboxylate [ No CAS ]
  • 9
  • [ 905710-14-7 ]
  • [ 41873-65-8 ]
  • tert-butyl 5-bromo-3-((2-(2-ethoxy-2-oxoethyl)phenoxy)methyl)-1H-indole-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
39% With (4-chlorobenzyl)diazene-1,2-dicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20℃; for 0.5h; General procedure: To a solution of (7-iodobenzofuran-2,5-diyl)dimethanol (7b) (500 mg, 1.644 mmol), triphenylphosphine (949 mg, 3.62 mmol) and ethyl 2-(2-hydroxyphenyl)acetate (7c) (652 mg, 3.62 mmol; CAS 41873-65-8) in DCM (30 mL) at 0 C was added dropwise bis(4- chlorobenzyl) diazene-l,2-dicarboxylate (DCAD) (1.33 g, 3.62 mmol) in DCM (20 mL). The reaction mixture was stirred for 30 min at room temperature. The suspension was filtered over a pad of Celite and the filtrate was concentrated in vacuum and purified by flash column chromatography [silica gel (40g), eluting with EtOAc in hexane from 0-50%] to give diethyl 2,2'-((((7-iodobenzofuran-2,5-diyl)bis(methylene))bis(oxy))bis(2, 1 -phenyl ene))diacetate (7d) (400 mg, 38.7 % yield) as a yellow oil; XH NMR (300 MH2, DMSO-d6) δ 7.76 (d, J= 1.5 H2, 1H), 7.69 (d, J= 1.5 H2, 1H), 7.29 - 7.20 (m, 5H), 7.14 (s, 1H), 7.06 (dd, J= 8.3, 1.1 Hz, 1H), 6.99 - 6.87 (m, 2H), 5.29 (s, 2H), 5.15 (s, 2H), 4.05 - 3.98 (m, 4H), 3.62 (s, 2H), 3.60 (s, 2H), 1.11 - 1.01 (m, 6H); MS (ES+): 651.1 (M+Na).
  • 10
  • [ 905710-14-7 ]
  • tert-butyl 5-(3-(aminomethyl)phenyl)-3-((2-(2-ethoxy-2-oxoethyl)phenoxy)methyl)-1H-indole-1-carboxylate [ No CAS ]
  • 11
  • [ 905710-14-7 ]
  • 2-(2-((5-(3-(aminomethyl)phenyl)-1-(tert-butoxycarbonyl)-1H-indol-3-yl)methoxy)phenyl)acetic acid [ No CAS ]
  • 2-(3-((5-(3-(aminomethyl)phenyl)-1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)-2-hydroxyphenyl)acetic acid [ No CAS ]
 

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Technical Information

Categories

Related Functional Groups of
[ 905710-14-7 ]

Bromides

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Alcohols

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Amides

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Related Parent Nucleus of
[ 905710-14-7 ]

Indoles

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A141887 [914349-05-6]

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A677333 [1337879-60-3]

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A117660 [96551-22-3]

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A133998 [914349-03-4]

tert-Butyl 3-(hydroxymethyl)-5-methyl-1H-indole-1-carboxylate

Similarity: 0.92

Chemical Structure| 914349-04-5

A136072 [914349-04-5]

tert-Butyl 3-(hydroxymethyl)-6-methyl-1H-indole-1-carboxylate

Similarity: 0.92