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Chemical Structure| 910866-32-9 Chemical Structure| 910866-32-9

Structure of 910866-32-9

Chemical Structure| 910866-32-9

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Product Details of [ 910866-32-9 ]

CAS No. :910866-32-9
Formula : C8H5F5O
M.W : 212.12
SMILES Code : FC1=CC=C(C(O)C(F)(F)F)C(F)=C1
MDL No. :MFCD12787297
InChI Key :QBWJVZAJXYEFOE-UHFFFAOYSA-N
Pubchem ID :61086802

Safety of [ 910866-32-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H227
Precautionary Statements:P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235

Application In Synthesis of [ 910866-32-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 910866-32-9 ]

[ 910866-32-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 910866-32-9 ]
  • [ 2799-07-7 ]
  • C30H24F5NO2S [ No CAS ]
  • 2(R)-[1-(2,4-difluorophenyl)-2,2,2-trifluoroethylamino]-3-tritylsulfanylpropionic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
2,2,2-Trifluoro-1-(2,4-difluorophenyl)ethanol (1.36 g, 6.4 mmol) was dissolved in dichloromethane (25 mL) and diisopropylethylamine (DIPEA, 5 mL, 28.8 mmol) was added. The resulting solution was cooled to -78 °C and trifluoromethanesulfonic anhydride (1.81 g, 6.4 mmol) was added. After 1 h, the reaction was warmed to -15 °C stirring was continued for 2 h. <strong>[2799-07-7]S-trityl-L-cysteine</strong> (2.33 g, 6.4 mmol) was then added and the reaction mixture was stirred overnight. After an aqueous work-up, the organic layer was dried with MgSO4 then filtered through silica using a combination of ethyl acetate and acetic acid to give a diastereomeric mixture of 2(R)-[I -(2,4-difluorophenyl)-2,2,2-trifluoroethylamino]-3- tritylsulfanylpropionic acid (2.47 g).
 

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