There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 91319-42-5 | MDL No. : | MFCD11617285 |
Formula : | C8H8BrFO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 219.05 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | 1759 |
Hazard Statements: | H302-H314 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | at 85℃; for 2 h; | To a solution of Scheme 57 compound 4 (1.5 g, 6.84 mmol) in dry EtOH (15 mL) was added NaCN (362 mg, 7.53 mmol) and the reaction mixture was stirred at 85 °C for 2 h. After TLC showed the starting material was completely consumed, the reaction mixture was concentrated to give a crude compound which was diluted with ice water (30 mL) and extracted with EtOAc (2 x 50 mL). The organic layer was washed with brine (20 mL) then dried over Na2S04 and concentrated to give a residue which was purified by flash chromatography on silica gel (petroleum ether/EtOAc 100/0 gradually increasing to 70/30) to give Scheme 57 compound 5 (1 g, 90percent) as a colorless liquid. 1H NMR (400 MHz, DMSO- d6): δ 7.21 (t, J= 9.2 Hz, 1H), 7.01 (dd, J= 6.1, 3.1 Hz, 1H), 6.94 (m, 1H), 4.01 (s, 2H), 3.75 (s, 3H). MS [ESI, MH+] = 166.06. |