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Chemical Structure| 91383-14-1 Chemical Structure| 91383-14-1

Structure of 91383-14-1

Chemical Structure| 91383-14-1

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Product Details of [ 91383-14-1 ]

CAS No. :91383-14-1
Formula : C9H17NO2
M.W : 171.24
SMILES Code : O=C(O)C[C@H](N)C1CCCCC1
MDL No. :MFCD07373036
InChI Key :XGRSAFKZAGGXJV-QMMMGPOBSA-N
Pubchem ID :738051

Safety of [ 91383-14-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 91383-14-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 91383-14-1 ]

[ 91383-14-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 91383-14-1 ]
  • [ 108-90-7 ]
  • (S)-3-(phenylamino)-3-cyclohexylpropanoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With di-tert-butyl{2′-isopropoxy-[1,1′-binaphthalen]-2-yl}phosphane; potassium hydroxide; bis(dibenzylideneacetone)-palladium(0); In tert-butyl alcohol; at 90.0℃; for 20.0h;Inert atmosphere; General procedure: An oven-dried resealable Schlenk flask was charged with Pd(dba)2 (11.4 mg, 0.02 mmol), L1 (13.6 mg, 0.03 mmol), base (3.0 mmol), and amino acid (1.20 mmol) under N2. tBuOH (2.5 mL) and aryl halides (1.00 mmol) were added in sequence via a syringe. The flask was sealed, and the mixture was allowed to heat to 90 C for 20 h. After being cooled to room temperature, the reaction mixture was diluted with 2 mL of water and 3 mL of CHCl3, and then adjusted to pH=3 with concentrated HCl. The organic layer was separated, and the aqueous layer was extracted with CHCl3 (5 mL×3). The combined organic layers were washed with brine, dried over Na2SO4, and concentrated. The residual oil was purified by column chromatography on silica gel (CHCl3/CH3OH) to afford the coupling product.
 

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