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Chemical Structure| 915192-34-6 Chemical Structure| 915192-34-6

Structure of 915192-34-6

Chemical Structure| 915192-34-6

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Product Details of [ 915192-34-6 ]

CAS No. :915192-34-6
Formula : C12H14O4
M.W : 222.24
SMILES Code : O=C(C1(C2=C(OC)C=CC=C2OC)CC1)O
MDL No. :MFCD19693574

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Application In Synthesis of [ 915192-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 915192-34-6 ]

[ 915192-34-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 915192-34-6 ]
  • [ 606-25-7 ]
  • 1-(2,6-dimethoxyphenyl)-N-(naphthalene-1-sulfonyl)cyclopropane-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 16h; To a mixture of Example I-7B (1-(2,6-dimethoxyphenyl)cyclopropanecarboxylic acid) (34 mg, 0.1 mmol), 33 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (69 mg, 0.36 mmol) and 34 4-dimethylaminopyridine (26 mg, 0.21 mmol) in anhydrous 35 dichloromethane (500 μL) was added 36 <strong>[606-25-7]naphthalene-1-sulfonamide</strong> (44 mg, 0.21 mmol). The mixture was stirred at ambient temperature for 16 hours, concentrated and purified by reverse-phase HPLC [Waters XBridge C18 5 μm OBD column, 30×100 mm, flow rate 40 mL/minute, 20 to 70% gradient of 37 acetonitrile in 0.1% 38 aqueous trifluoroacetic acid] to provide the 70 title compound. 1H NMR (400 MHz, dimethyl sulfoxide-d6) δ ppm 11.07 (s, 1H), 8.57-8.52 (m, 1H), 8.28 (dd, J=8.3, 1.1 Hz, 1H), 8.23 (dd, J=7.5, 1.2 Hz, 1H), 8.14-8.08 (m, 1H), 7.73-7.64 (m, 3H), 7.25 (t, J=8.4 Hz, 1H), 6.59 (d, J=8.4 Hz, 2H), 3.58 (s, 6H), 1.40-1.36 (m, 2H), 0.92-0.88 (m, 2H)+ MS (ESI) m/z 412 (M+H)+
  • 2
  • [ 16932-45-9 ]
  • [ 915192-34-6 ]
 

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