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Chemical Structure| 916325-86-5 Chemical Structure| 916325-86-5

Structure of 916325-86-5

Chemical Structure| 916325-86-5

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Product Details of [ 916325-86-5 ]

CAS No. :916325-86-5
Formula : C8H12N2O
M.W : 152.19
SMILES Code : NC1=CC=CC(COC)=C1N

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Application In Synthesis of [ 916325-86-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 916325-86-5 ]

[ 916325-86-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 916325-85-4 ]
  • [ 916325-86-5 ]
  • [ 948834-63-7 ]
  • 2
  • [ 74-88-4 ]
  • [ 273749-25-0 ]
  • [ 916325-86-5 ]
  • 3
  • [ 916325-85-4 ]
  • [ 916325-86-5 ]
  • N-[2-amino-3-(methoxymethyl)phenyl]-5-bromo-1H-pyrazolo[3,4-b]pyridin-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
57% With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; Compound Ic (1.425 g, 5.89 mmol), Compound Ie (0.896 g, 5.89 mmol), HATU (2.686 g, 7.07 mmol) and DIPEA (3.69 mL, 21.2 mmol) in DMF (15 mL) was stirred at, room temperature overnight. The mixture was then evaporated in vacuo and . purified via chromatography on silica gel with a 10-20% MeOH/methylene chloride gradient to give Compound If 1.265 g (57%). 1H NMR (300 MHz, (CD3)2SO) delta 9.9 (s, br, IH), 8.72 (s, IH), 8.65 (s, IH), 7.25 (d, IH), 7.0 (d, IH), 6.62 (t, IH), 4.7 (s, br, 2H), 4.40 (s, 2H), 3.30 (s, 3H); MS (ESI) m/z: 377 (M+H+), 399 (M+Na+).
 

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