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Chemical Structure| 916792-17-1 Chemical Structure| 916792-17-1

Structure of 916792-17-1

Chemical Structure| 916792-17-1

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Product Details of [ 916792-17-1 ]

CAS No. :916792-17-1
Formula : C8H6BrFO
M.W : 217.04
SMILES Code : CC1=CC(C=O)=C(Br)C=C1F
MDL No. :MFCD07782045

Safety of [ 916792-17-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 916792-17-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 916792-17-1 ]

[ 916792-17-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 916792-17-1 ]
  • [ 1003709-39-4 ]
YieldReaction ConditionsOperation in experiment
93% With sodium chlorite; potassium dihydrogenphosphate; aminosulfonic acid; In 1,4-dioxane; water; at 20.0℃; A mixture of 2-bromo-4-fluoro-5-methyl-benzaldehyde (available from 3B Scientific Corporation, 1840 Industrial Drive, Suite 160, LibertyviUe, IL 60048, USA; 1.0 g, 4.61 mmol), sulfamic acid (2.68 g, 27.65 mmol), sodium chlorite (539 mg, 6 mmol) and KH2P04 (7.52 g, 55.3 mmol) in 50% aqueous dioxane (96 mL) was stirred at room temperature overnight. The reaction mixture was concentrated, and water (20 mL) was added. The resulting mixture was extracted with EtOAc (3 x 250 mL). The combined organic layers were dried (Na2S04), filtered, and evaporated to give 2-bromo-4-fluoro-5-methyl-benzoic acid (1.0 g, 93%) as an off-white solid. MS calcd. for C8H7BrF02 [(M-H) ] 231, obsd. 231.0.
 

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