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Chemical Structure| 918538-06-4 Chemical Structure| 918538-06-4

Structure of 918538-06-4

Chemical Structure| 918538-06-4

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Product Details of [ 918538-06-4 ]

CAS No. :918538-06-4
Formula : C10H9ClN6
M.W : 248.67
SMILES Code : CC1=CC(NC2=NC(Cl)=NN3C2=CC=C3)=NN1
MDL No. :N/A

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Application In Synthesis of [ 918538-06-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 918538-06-4 ]

[ 918538-06-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 918538-06-4 ]
  • [ 130464-05-0 ]
  • (R)-N-(5-methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In NMP (N-methylpyrrolidin-2-one); at 130℃; for 72h; Example 114 (R)-N-(5-Methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine TFA salt 2(R)-Pyrrolidin-2-ylpyridine (447 mg, 3.0 mmol) was added to a mixture containing 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (250 mg, 1.00 mmol) (Example 113A) and diisopropylethylamine (780 mg, 6.03 mmol) in NMP. The reaction mixture was heated at 130 C. for 72 hours and then reaction mixture diluted with ethyl acetate:water (20 mL, 4:1). The organic layer was separated and washed with water, dried (Na2SO4) and concentrated to afford the crude product. The crude product was dissolved in methanol and purified using preparative HPLC using the conditions shown below to afford 80 mg of (R)-N-(5-methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine as the TFA salt.
 

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