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Structure of 130464-05-0

Chemical Structure| 130464-05-0

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Product Details of [ 130464-05-0 ]

CAS No. :130464-05-0
Formula : C9H12N2
M.W : 148.21
SMILES Code : C1([C@@H]2NCCC2)=NC=CC=C1
MDL No. :MFCD07374401
InChI Key :NDCZQFDBSPOUDF-SECBINFHSA-N
Pubchem ID :7141590

Safety of [ 130464-05-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 130464-05-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130464-05-0 ]

[ 130464-05-0 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 918538-06-4 ]
  • [ 130464-05-0 ]
  • (R)-N-(5-methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In NMP (N-methylpyrrolidin-2-one); at 130℃; for 72h; Example 114 (R)-N-(5-Methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine TFA salt 2(R)-Pyrrolidin-2-ylpyridine (447 mg, 3.0 mmol) was added to a mixture containing 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (250 mg, 1.00 mmol) (Example 113A) and diisopropylethylamine (780 mg, 6.03 mmol) in NMP. The reaction mixture was heated at 130 C. for 72 hours and then reaction mixture diluted with ethyl acetate:water (20 mL, 4:1). The organic layer was separated and washed with water, dried (Na2SO4) and concentrated to afford the crude product. The crude product was dissolved in methanol and purified using preparative HPLC using the conditions shown below to afford 80 mg of (R)-N-(5-methyl-1H-pyrazol-3-yl)-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine as the TFA salt.
  • 2
  • [ 1262117-00-9 ]
  • [ 130464-05-0 ]
  • 3
  • [ 130464-05-0 ]
  • [ 1079-66-9 ]
  • 2-[(R)-1-(diphenylphosphinoborane)pyrrolidin-2-yl]pyridine [ No CAS ]
  • 4
  • [ 131684-98-5 ]
  • [ 130464-05-0 ]
  • 5
  • 2-((R)-1-((S)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-yl)pyridine [ No CAS ]
  • [ 130464-05-0 ]
YieldReaction ConditionsOperation in experiment
45% With trifluoroacetic acid; at 50℃; for 12h; The solution of 2-((R)-l-((5)-l-(4- methoxyphenyl)ethyl)pyrrolidin-2-yl)pyridine (400 mg, 1.48 mmol) in TFA (5 mL) was stirred at 50C for 12h. The reaction mixture was concentrated and 1M HC1 aqueous (15 mL) was added. This solution was wash with dichloromethane (5 mL x 3). Then saturated NaHCC>3 solution was added to adjust pH to 9, and extracted with dichloromethane (10 mL x 5). The combined organic layer was dried over Na2S04, filtered and evaporated to give the desired product (100 mg, 45%) as a colorless oil.
  • 6
  • [ 100-70-9 ]
  • [ 130464-05-0 ]
 

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[ 130464-05-0 ]

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A474422 [2718120-94-4]

(R)-2-(Pyrrolidin-2-yl)pyridine dihydrochloride

Reason: Free-Salt