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Chemical Structure| 927804-72-6 Chemical Structure| 927804-72-6

Structure of 927804-72-6

Chemical Structure| 927804-72-6

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Product Details of [ 927804-72-6 ]

CAS No. :927804-72-6
Formula : C10H10N2O3
M.W : 206.20
SMILES Code : O=C(C(O1)=C(N)C2=C1C=NC=C2)OCC
MDL No. :MFCD17214268

Safety of [ 927804-72-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 927804-72-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 927804-72-6 ]

[ 927804-72-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 927804-72-6 ]
  • [ 160893-07-2 ]
  • Ethyl 3-(5-methoxyquinolin-2-ylamino)furo[2,3-c]pyridine-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
99% With potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;XPhos; In 1,4-dioxane;Heating / reflux; Step A: Ethyl 3-(5-methoxyquinolin-2-ylamino)furo[2,3-c]pyridine-2-carboxylate: <strong>[160893-07-2]2-chloro-5-methoxyquinoline</strong> (0.123 g, 0.635 mmol) and ethyl 3-aminofuro[2,3-c]pyridine-2-carboxylate (0.144 g, 0.70 mmol) were suspended in p-dioxane (6.0 mL) and degassed with Ar for 15 minutes. To this was added 1,3-bis(2,6-diisopropylphenyl)-1H-imidazole-3-ium chloride (0.054 g, 0.127 mmol), Pd2(dba)3 (0.058 g, 0.0635 mmol), and KOt-Bu (0.107 g, 0.953 mmol). The reaction was degassed with Ar for another 15 minutes and then reflux under Ar overnight, then cooled to ambient temperature, filtered through GF/F paper, rinsed with dichloromethane and concentrated. The crude product was purified by flash column chromatography, eluting with hexanes/ethyl acetate (4:1) to give the desired product (265 mg, 99%). MS (APCI) m/z 364.1 (M+1).
 

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