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Chemical Structure| 93534-22-6 Chemical Structure| 93534-22-6

Structure of 93534-22-6

Chemical Structure| 93534-22-6

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Product Details of [ 93534-22-6 ]

CAS No. :93534-22-6
Formula : C14H10Cl2O
M.W : 265.14
SMILES Code : ClC1=CC=C(C(CC2=CC=CC=C2)=O)C=C1Cl
MDL No. :MFCD06201641

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Application In Synthesis of [ 93534-22-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93534-22-6 ]

[ 93534-22-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 57-13-6 ]
  • [ 93534-22-6 ]
  • [ 1283117-56-5 ]
YieldReaction ConditionsOperation in experiment
17% With hydrogenchloride; In ethanol; water; for 48.0h;Reflux; 00192] To a solution of l-(3,4-dichlorophenyl)-2-phenylethanone (Intermediate 19)(100 mg, 0.38 mmol), <strong>[178686-24-3]3-ethoxy-4-hydroxy-5-nitrobenzaldehyde</strong> (74.4 mg, 0.38 mmol), and urea (68.5 mg, 1.14 mmol) in 5 mL of ethanol was added 0.2 mL of concentrated HC1 solution, and the mixture was refluxed for 2 days. After the solvent was removed under reduced pressure, the residue was purified by reverse-phase preparatory HPLC (26-53% acetonitrile + 0.1% trifluoroacetic acid in water + 0.1% trifluoroacetic acid, over 15 min.) to give Compound 47 (32 mg, yield 17.0%). 1H NMR (DMSO- 6 300 MHz) delta 10.28 (s, 1H), 8.85 (s, 1H), 7.58 (s, 1H), 7.48 (t, J = 1.5 Hz, 2H), 7.41 (d, J = 1.8 Hz, 1H), 7.13-7.05 (m, 5H), 6.88 (t, J = 1.8 Hz, 2H), 5.25 (d, J = 2.1 Hz, 1H), 4.02 (m, 2H), 1.32 (t, J = 6.9 Hz, 3H); MS(ESI): m/z 499.9 [M+l]+.
 

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