Structure of 937046-95-2
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CAS No. : | 937046-95-2 |
Formula : | C9H14N2O2 |
M.W : | 182.22 |
SMILES Code : | O=C(OC(C)(C)C)NN1C=CC=C1 |
MDL No. : | MFCD09863891 |
InChI Key : | JDOTVVAIWOCYFL-UHFFFAOYSA-N |
Pubchem ID : | 49760548 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H317 |
Precautionary Statements: | P280 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | Under the protection of inert gas, 1000g of intermediate I (5.49mol, 1.0eq) and 10L of anhydrous acetonitrile were added to a 20L three-necked bottle. After stirring thoroughly, the temperature was lowered to 0 C, and 500ml of chlorosulfonyl isocyanate was slowly added dropwise (5.77mol, 1.05eq). Keeping the internal temperature below 5 C, a white suspension can be observed in about 20 minutes. After 30 min, 1 L of anhydrous DMF was added, and the reaction solution became clear. Keep the reaction at 0 for 30min. After the reaction is completed, pour the reaction solution into a mixture of ice water and ethyl acetate, and stir to separate. The organic phase was washed successively with saturated sodium bicarbonate solution and brine, then dried over anhydrous sodium sulfate, separated and concentrated to obtain 980 g of white solid. That is the intermediate II (1-Boc-1-amino-(9ci)-1H-pyrrole-2-carbonitrile). The purity of this intermediate II was 97%, and the yield was 87%. | |
77% | In N,N-dimethyl-formamide; acetonitrile; at 0 - 20℃; for 1.83333h; | A 2L, 3-neck RB was fitted w/ stir bar, N2 inlet, rubber septum low-temp, thermometer and ice/acetone cooling bath. Pyrrol- 1-yl-carbamic acid tert-butyl ester (99.0 g, 0.543 mol) was added to the reactor, dissolved w/ anhydrous acetonitrile (700 mL) and the stirred solution was cooled to 0 0C. Chlorosulfonyl isocyanate (49.7 mL, 0.57 mol) was added dropwise via syringe (maintaining an internal temp, below 5 0C); after ~ 20 minutes a suspension was observed. After 45 minutes N,N-dimethylformamide (anhydrous, 100 mL) was added dropwise via addition funnel (keeping internal temp, below 5 0C) and the reaction mixture became a solution. Stirring @ 0 0C was continued for 45 minutes, then the reaction was allowed to warm to RT; monitoring by TLC (silica gel, 1:3 ethyl acetate/hexane, UV, ninhydrin stain) of a quenched sample indicated that the reaction had progressed to completion. The mixture was poured onto ice (~2L) and stirred with addition of EtOAc (2L). The layers were separated and the organic layer was dried over magnesium sulfate. The dried solution was filtered through a pad of 30/40 Magnesol and the filtrate was concentrated to dryness in vacuo, then the residue was dissolved in a minimum volume of dichloromethane and chromatographed on a plug of silica gel, eluting with ethyl <n="255"/>acetate/hexane, 0-50 % ethyl acetate. The clean, product-containing fractions were combined and concentrated to dryness in vacuo, to afford the desired product as a white solid, 69.8 g (62%). A somewhat impure fraction provided additional material, 16.8 g (15%), bringing the total recovery to 86.6 g, (77%). 1H-NMR (CD3OD): delta 7.01 (dd, IH, J = 3.0, 1.6 Hz), 6.82 (dd, IH, J = 4.4, 1.7 Hz), 6.19 (dd, IH, /=4.2, 2.9 Hz), 4.88 (s, IH, H2ONH-), 1.50 (br s, 9H, HN-BOC); MS: LC/MS (+esi), m/z=207.9 [M+H]. |
77% | A 2L, 3-neck RB was fitted w/ stir bar, N2 inlet, rubber septum low-temp, thermometer and ice/acetone cooling bath. Pyrrol-1-yl-carbamic acid tert-butyl ester (99.0 g, 0.543 mol) was added to the reactor, dissolved w/ anhydrous acetonitrile (700 mL) and the stirred solution was cooled to 0 0C. Chlorosulfonyl isocyanate (49.7 mL, 0.57 mol) was added dropwise via syringe (maintaining an internal temperature below 5 0C); after ~ 20 minutes a suspension was observed. After 45 minutes Lambda/,Lambda/-dimethylformamide (anhydrous, 100 mL) was added dropwise via addition funnel (keeping internal temp. below 5 0C) and the reaction mixture became a solution. Stirring (at) 0 0C was continued for 45 minutes, then the reaction was allowed to warm to RT; monitoring by TLC (silica gel, 1 :3 ethyl acetate/hexane, UV, ninhydrin stain) of a quenched sample indicated that <n="75"/>the reaction had progressed to completion. The mixture was poured onto ice (~2L) and stirred with addition of EtOAc (2L). The layers were separated and the organic layer was dried over magnesium sulfate. The dried solution was filtered through a pad of 30/40 Magnesol and the filtrate was concentrated to dryness in vacuo, then the residue was dissolved in a minimum volume of dichloromethane and chromatographed on a plug of silica gel, eluting with ethyl acetate/hexane, 0-50 % ethyl acetate. The clean, product- containing fractions were combined and concentrated to dryness in vacuo, to afford the desired product as a white solid, 69.8 g (62%). A somewhat impure fraction provided additional material, 16.8 g (15%), bringing the total recovery to 86.6 g, (77%). 1H-NMR (CD3OD): 87.01 (dd, 1H, J = 3.0, 1.6 Hz), 6.82 (dd, 1H, J = 4.4, 1.7 Hz), 6.19 (dd, 1H, J=4.2, 2.9 Hz), 4.88 (s, 1H, H2O+NH-), 1.50 (br s, 9H, HN-BOC); MS: LC/MS (+esi), m/z=207.9 [M+H]; Intermediate G: Step 2: Preparation of (2-Cvano-pyrrol-1-yl)-carbamic acid, fe/f-butvl esterA 2L, 3-neck flask was fitted with stir bar, N2 inlet, rubber septum, thermometer and ice/acetone cooling bath. Pyrrol-1-yl-carbamic acid terf-butyl ester (99.0 g, 0.543 mol) was added to the reactor, dissolved with anhydrous acetonitrile (700 mL) and the stirred solution was cooled to 0 0C. Chlorosulfonyl isocyanate (49.7 mL, 0.57 mol) was added dropwise via syringe (maintaining an internal temperature below 5 CC). After ~ 20 minutes a suspension was observed. After 45 minutes, Lambda/,Lambda/-dimethylformamide (anhydrous, 100 mL) was added dropwise via addition funnel (keeping internal temperature below 5 0C) and the reaction mixture became a solution. Stirring at 0 0C was continued for 45 minutes, then the reaction was allowed to warm to rt. Monitoring by TLC (silica gel, 1:3 ethyl acetate/hexane, UV, ninhydrin stain) of a quenched sample indicated that the reaction had progressed to completion. The mixture was poured onto ice (~2L) and stirred with addition of EtOAc (2L). The layers were separated and the organic layer was dried over magnesium sulfate. The dried solution was filtered through a pad of 30/40 <n="81"/>Magnesol and the filtrate was concentrated to dryness in vacuo, then the residue was dissolved in a minimum volume of dichloromethane and chromatographed on a plug of silica gel, eluting with ethyl acetate/hexane, 0-50 % ethyl acetate. The clean, product- containing fractions were combined and concentrated to dryness in vacuo, to afford the desired product as a white solid, 69.8 g (62%). A somewhat impure fraction provided additional material, 16.8 g (15%), bringing the total recovery to 86.6 g, (77%). 1H-NMR (CD3OD): delta 7.01 (dd, 1H, J= 3.0, 1.6 Hz), 6.82 (dd, 1H, J = 4.4, 1.7 Hz), 6.19 (dd, 1H, J= 4.2, 2.9 Hz), 4.88 (s, 1H), 1.50 (br s, 9H); MS: LC/MS (+esi), m/z=207.9 [M+H]. |
77% | In N,N-dimethyl-formamide; acetonitrile; at 0 - 5℃; for 1.83333h; | A 2L, 3 -neck RB was fitted w/ stir bar, N2 inlet, rubber septum low-temp, thermometer and ice/acetone cooling bath. Pyrrol- 1-yl-carbamic acid tert-butyl ester (99.0 g, 0.543 mol) was added to the reactor, dissolved w/ anhydrous acetonitrile (700 mL) and the stirred solution was cooled to 0 C. Chlorosulfonyl isocyanate (49.7 mL, 0.57 mol) was added dropwise via syringe (maintaining an internal temp, below 5 0C); after ~ 20 minutes a suspension was observed. After 45 minutes N,N-dimethylformamide (anhydrous, 100 mL) was added dropwise via addition funnel (keeping internal temp, below 5 0C) and the reaction mixture became a solution. Stirring @ 0 0C was continued for 45 minutes, then the reaction was allowed to warm to RT; monitoring by TLC (silica gel, 1:3 ethyl acetate/hexane, UV, ninydrin stain) of a quenched sample indicated that the reaction had progressed to completion. The mixture was poured onto ice (~2L) and stirred with addition of EtOAc (2L). The layers were separated and the organic layer was dried over magnesium sulfate. The dried solution was filtered through a pad of 30/40 Magnesol and the filtrate was concentrated to dryness in vacuo, then the residue was dissolved in a minimum volume of dichloromethane and chromatographed on a plug of silica gel, eluting with ethyl acetate/hexane, 0-50 % ethyl acetate. The clean, product-containing fractions were combined and concentrated to dryness in vacuo, to afford the desired product as a white solid, 69.8 g (62%). A somewhat impure fraction provided additional material, 16.8 g (15%), bringing the total recovery to 86.6 g, (77%). 1H-NMR (CD3OD): £7.01 (dd, IH, J = 3.0, 1.6 Hz), 6.82 (dd, IH, / = 4.4, 1.7 Hz), 6.19 (dd, IH, J=4.2, 2.9 Hz), 4.88 (s, IH,H2O+NH-), 1.50 (br s, 9H, HN-BOC); MS: LC/MS (+esi), m/z=207.9 [M+H] |
66% | g. To a stirred solution of tert-butyl lH-pyrrol-1-ylcarbamate 12 (40 g, 219.52 mmol), in acetonitrile (350 mL) was added chlorosulfonyl isocyanate (32.62 g, 230.50 mmol) slowly at 0 C and continued stirring at 0 0C for 30 min. To the solution N, N-dimethyl formamide (40 mL) was added below 5 0C and continued stirring at 0 0C for 1 hr. The reaction mixture was poured into a mixture of crushed ice (1 L) and ethyl acetate (1 L). The layers were separated and the organic layer was washed with water (500 mL), brine (250 mL), dried and concentrated in vacuum to furnish crude (43 g) product. The crude was purified by flash chromatography (silica gel, eluting with ethyl acetate in hexane 0-50%) to afford pure tert-butyl 2-cyano-lH-pyrrol-l-ylcarbamate 13 (30 g, 66 %) as a colorless solid. 1H NMR (300 MHz, DMSO) delta 10.80 (s, IH, D2O exchangeable), 7.23 (dd, J = 1.7, 2.9, IH), 6.94 (dd, J= 1.7, 4.3, IH), 6.20 (dd, J= 2.9, 4.3, IH), 1.45 (s, 9H). HPLC (Zorbax SBC3, 3.0 x 150 mm, 5 mum, with ZGC SBC3, 2.1 x 12.5 mm guard cartridge. Mobile phase: 0.1 M ammonium acetate/ Acetonitrile) Rt = 16.216, (98.14 %). Analysis: CaIc for C10H13N3O2: C, 57.95; H, 6.32; N, 20.27 Found: C, 58.02; H, 6.45; N, 20.18. | |
66% | To a stirred solution of tert-butyl lH-pyrrol-l-ylcarbamate 12c (40 g, 219.52 mmol), in acetonitrile (350 mL) was added chlorosulfonyl isocyanate (32.62 g, 230.50 mmol) slowly at 0 C and continued stirring at 0 C for 30 min. To the solution N, N-dimethyl formamide (40 mL) was added below 5 C and continued stirring at 0 C for 1 hr. The reaction mixture was poured into a mixture of crushed ice (1 L) and ethyl acetate (1 L). The layers were separated and the organic layer was washed with water (500 mL), brine (250 mL), dried and concentrated in vacuum to furnish crude (43 g) product. The crude was purified by flash chromatography (silica gel, eluting with ethyl acetate in hexane 0-50%) to afford pure tert-butyl 2-cyano-lH-pyrrol-l- ylcarbamate 12d (30 g, 66 %) as a colorless solid. 1H NMR (300 MHz, DMSO) delta 10.80 (s, 1H, D20 exchangeable), 7.23 (dd, J= 1.7, 2.9, 1H), 6.94 (dd, J= 1.7, 4.3, 1H), 6.20 (dd, J= 2.9, 4.3, 1H), 1.45 (s, 9H). HPLC (Zorbax SBC3, 3.0 x 150 mm, 5 mu?iota, with ZGC SBC3, 2.1 x 12.5 mm guard cartridge. Mobile phase: 0.1 M ammonium acetate/ Acetonitrile) Rt = 16.216, (98.14 %). Analysis: Calc for C10H13N3O2: C, 57.95; H, 6.32; N, 20.27 Found: C, 58.02; H, 6.45; N, 20.18. | |
66% | Step 1:To a stirred solution of tert-butyl hydrazinecarboxylate 22b (50 g, 412.37 mmol) and 2,5-dimethoxytetrahydrofuran 22a (54.5 g, 412.37 mmol) in dioxane (300 mL) was added aqueous hydrochloric acid (5 mL, 2N). The reaction was set up using a dean-stark apparatus and heated at 90 C for 20 h. Reaction mixture was cooled to 20 C, neutralized with saturated sodium bicarbonate (18 mL) and filtered to remove inorganics. The filtrate was concentrated in vacuum and triturated with ether. The solid obtained was collected by filtration to furnish on drying tert-butyl lH-pyrrol-l-ylcarbamate 22c (43 g, 57.2%) as a yellow brown solid. 1H NMR (300 MHz, CD3OD) ? 6.62 (t, J= 2.3, 2H), 6.02 (t, J= 2.3, 2H), 1.48 (s, 9H); MS (ES+): 181.1 (M _1). Analysis: Calculated for C9Hi4N202: C, 59.32; H, 7.74; N, 15.37. Found: C, 59.32; H, 7.65; N, 15.02. Step 2:To a stirred solution of tert-butyl lH-pyrrol-l-ylcarbamate 22c (40 g, 219.52 mmol), in acetonitrile (350 mL) was added chlorosulfonyl isocyanate (32.62 g, 230.50 mmol) slowly at 0 C and continued stirring at 0 C for 30 min. To the solution N, N-dimethyl formamide (40 mL) was added below 5 C and continued stirring at 0 C for 1 hr. The reaction mixture was poured into a mixture of crushed ice (1 L) and ethyl acetate (1 L). The layers were separated and the organic layer was washed with water (500 mL), brine (250 mL), dried and concentrated in vacuum to furnish crude (43 g) product. The crude was purified by flash chromatography (silica gel, eluting with ethyl acetate in hexane0-50%) to afford pure tert-butyl 2-cyano-lH-pyrrol-l-ylcarbamate 22d (30 g, 66 %>) as a colorless solid. 1H NMR (300 MHz, DMSO-d6) ? 10.80 (s, 1H, D20 exchangeable), 7.23 (dd, J= 1.7, 2.9, 1H), 6.94 (dd, J= 1.7, 4.3, 1H), 6.20 (dd, J= 2.9, 4.3, 1H), 1.45 (s, 9H). Analysis: Calculated for Ci0Hi3N3O2: C, 57.95; H, 6.32; N, 20.27. Found: C, 58.02; H, 6.45; N, 20.18. Step 3:To a stirred solution of tert-butyl 2-cyano-lH-pyrrol-l-ylcarbamate 22d (5 g, 24.12 mmol) in ethyl alcohol (100 mL) was added concentrated aqueous ammonium hydroxide solution (50 mL) at 20 C followed by hydrogen peroxide (7.4 mL, 72.38 mmol, 30 % in water) slowly at 20 C and stirred at the same temperature for 16 h. Reaction mixture was concentrated in vacuum and diluted with ethyl acetate (150 mL), washed with water (2 x 50 mL). The aqueous layer was extracted with ethyl acetate (150 mL). The combined ethyl acetate layers were washed with water (100 mL), brine (50 mL), dried, filtered, and concentrated in vacuum. The residue obtained was crystallized from diisopropyl ether and hexane to afford tert-butyl 2-carbamoyl-lH-pyrrol-l-ylcarbamate 22e (4.0 g, 73.6%) as a colorless solid. 1H NMR (300 MHz, DMSO-d6) ? 9.89 (s, 1H, D20 exchangeable), 7.31 (d, J = 38.5, 1H), 6.84 (dd, J= 1.9, 2.8, 2H, lH is D20 exchangeable), 6.76 (dd, J = 1.9, 4.2, 1H), 5.97 (dd, J= 2.8, 4.2, 1H), 1.40 (s, 9H); Analysis: Calculated for Ci0Hi5N3O3: C, 53.32; H, 6.71 ; N, 18.65. Found: C, 53.40; H, 6.74; N, 18.55. Step 4:To a solution of tert-butyl 2-carbamoyl-lH-pyrrol-l-ylcarbamate 22e (2g, 8.87 mmol) in dichloromethane (15 mL) was added trifluoro acetic acid (15 mL) at 20 C and stirred for 30 min. The reaction mixture was concentrated to dryness to remove excess trifluoroacetic acid and diluted with dichloromethane. Triethylorthoformate (30 mL) was added to the residue and was heated to 79 C overnight. Reaction mixture was concentrated to dryness and triturated with hexanes, the solid obtained was collected by filtration dried in vacuum to give crude pyrrolo[l ,2-f][l ,2,4]triazin-4-ol 22f (1.1 g, 91%) as a dark brown solid. 1H NMR (300 MHz, DMSO-d6) ? 11.63 (s, 1H, D20 exchangeable), 7.83 (d, J= 4.0, 1H), 7.59 (dd, J= 1.7, 2.6, 1H), 6.89 (dd, J= 1.6, 4.3, 1H), 6.54 (dd, J = 2.7, 4.3, 1H); MS (ES+): 136.2 (M + l). Step 5:The stirred solution of pyrrolo[l ,2-f][l ,2,4]triazin-4-ol 22f (1 g, 7.40 mmol), benzyltriethylammonium chloride (3.29 g, 14.80 mmol), and N,N-dimethylaniline (1.35 g, 1 1.10 mmol) in acetonitrile (25 mL) was heated to 80 C and at this temperature phosphorous oxy chloride (6.88 g, 44.40 mmol) was added and stirred at 80 C for 16 h. The reaction was concentrated to remove acetonitrile and phosphorus oxy chloride. The reaction was quenched by adding ice water (20 mL) and extracted with ethyl acetate (2 x 100 mL). The ethyl acetate extracts were combined washed with hydrochloric acid (1 N, 30 mL), water (50 mL), saturated sodium bicarbonate (1 x 20 mL), water (50 mL), brine (20 mL) dried and concentrated. The crude residue was purified by flash chromatography (silica gel, eluting with ethyl acetate in hexanes (0 to 5 %)) to furnish pure4-chloropyrrolo[l,2-fJ[l,2,4]triazine 22g (0.7 g, 61.6 %) as a colorless oil, which solidified on standing in refrigerator. 1H NMR (300 MHz, DMSO-d6) ? 8.44 (s, 1H), 8.27 (dd, J = 1.5, 2.5, 1H), 7.12 (qd, J= 2.0, 4.6, 2H). Step 6:A solution of 2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (10m) (2.3 g, 9.8 ... | |
Example 2: tert-butyl (2-cyano- lH-pyrrol- 1 -yl)carbamateUnder an atmosphere of nitrogen, the suspension of the compound (322g) prepared in Example 1 in acetonitrile (2L) was added into a flask. The solution was cooled to -70C. Chlorosulfonyl isocyanate (162mL, 1.86mol) was dropped into the solution and was stirred for an hour at O0C. Then, N,N-dimethylformamide (DMF) (325mL) was dropped into the mixture and stirred for an hour at 5C. The reaction solution was poured into iced water (4L) and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel (hexane: ethyl acetate = 1:0 - >;4:1 ->; 3:1 - >; 3:2). The obtained solids were washed in hexane/diisopropylether (1:1; 40OmL) to obtain the title compound (148g) as a white solid. The filtrate was concentrated and washed in hexane/diisopropylether (10:1; 30OmL) to obtain the title compound (112g) as a white solid. A total of 26Og of the title compound having the following physical data was obtained.TLC: Rf 0.42 (hexane : ethyl acetate = 3:1);1HNMR (300 MHz, CDCl3) delta ppm 1.52 (s, 9 H) 6.19 (dd, J=4.4, 2.9 Hz, 1 H) 6.79 (dd, J=4.4, 1.8 Hz, 1 H) 6.90 (dd, J=2.9, 1.8 Hz, 1 H) 7.26 (s, 1 H). |
Tags: 937046-95-2 synthesis path| 937046-95-2 SDS| 937046-95-2 COA| 937046-95-2 purity| 937046-95-2 application| 937046-95-2 NMR| 937046-95-2 COA| 937046-95-2 structure
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P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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