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Chemical Structure| 93744-72-0 Chemical Structure| 93744-72-0

Structure of 93744-72-0

Chemical Structure| 93744-72-0

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Product Details of [ 93744-72-0 ]

CAS No. :93744-72-0
Formula : C7H10N4OS
M.W : 198.25
SMILES Code : S=C(N)NC1=NC(C)=CC(OC)=N1
MDL No. :MFCD03291910

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Application In Synthesis of [ 93744-72-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93744-72-0 ]

[ 93744-72-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 93744-72-0 ]
  • [ 26638-43-7 ]
  • methyl 2-[[1-(4-methoxy-6-methylpyrimidin-2-ylimino)-1-(methylthio)methyl]aminosulfonyl]benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; dimethyl sulfate; In tetrahydrofuran; dichloromethane; water; EXAMPLE 5 Methyl 2-[[1-(4-methoxy-6-methylpyrimidin-2-ylimino)-1-(methylthio)methyl]aminosulfonyl]benzoate To 9 g of the compound from Example 4 and 100 ml of tetrahydrofuran was added 7.6 g of dimethyl sulfate and the mixture was stirred for 2 days at room temperature. The product was filtered and washed with a little tetrahydrofuran to give 22 g of crude product. Five grams of this material was suspended in 150 ml of methylene chloride and 1 ml of water, and 5 g of sodium bicarbonate and 6 g of methyl 2-chlorosulfonyl benzoate were added. The mixture was stirred for 24 hours, washed with dilute aqueous HCl, dried with sodium sulfate, filtered, and chromatographed on silica gel to afford 2.8 g of the title compound as a crystalline solid, m.p. 143-144. Anal. Calc'd.: C: 45.22, H: 4.55, N: 14.06, S: 16.1. Found: C: 46.8, H: 4.35, N: 13.2, S: 16. m/e 395 (M+ --CH3). NMR(CDCl3) delta2.35 (s,3), 2.45 (s,3), 3.90 (s,3), 4.0 (s,3) 6.35 (s,1), 7.7 (m, 3), 8.2 (m, 1), 10.8 (brs, 1).
 

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