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Chemical Structure| 94058-85-2 Chemical Structure| 94058-85-2

Structure of 94058-85-2

Chemical Structure| 94058-85-2

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Product Details of [ 94058-85-2 ]

CAS No. :94058-85-2
Formula : C11H11ClN2O2
M.W : 238.67
SMILES Code : ClC1=CC=C(OC(N2CCOCC2)=N3)C3=C1

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Application In Synthesis of [ 94058-85-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94058-85-2 ]

[ 94058-85-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 94058-85-2 ]
  • [ 618910-07-9 ]
  • C24H26N4O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
15% With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; ruphos; In 1,4-dioxane; at 100.0℃;Inert atmosphere; General procedure: To a stirred solution of the title compound of Preparative Example 1 (0.150 g, 1 eq) in dry 1 ,4- dioxane (5 mL) was added the commercially available 4-(6-bromobenzo[d]thiazoI-2- yl)morpholine (1 eq), sodium tert-butoxide (3 eq) and the mixture was degassed for 10 minutes under N2 atmosphere. To this reaction mixture was added Pd2(dba)3 (0.05 eq) and Ru-Phos (0.1 eq) and the mixture was heated to 100C until the completion of the reaction. After the completion of the reaction, the reaction mixture was filtered through a celite bed, and washed with EtOAc. The filtrate was concentrated and the crude product was purified by column chromatography or preparative HPLC to afford title compound 6 as indicated in table 2.
 

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