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Chemical Structure| 942919-24-6 Chemical Structure| 942919-24-6

Structure of 942919-24-6

Chemical Structure| 942919-24-6

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Product Details of [ 942919-24-6 ]

CAS No. :942919-24-6
Formula : C19H21BN2O4S
M.W : 384.26
SMILES Code : CC1(C)OB(C2=C3C(N(S(=O)(C4=CC=CC=C4)=O)C=C3)=NC=C2)OC1(C)C
MDL No. :MFCD10574997

Safety of [ 942919-24-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 942919-24-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 942919-24-6 ]

[ 942919-24-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 13195-50-1 ]
  • [ 942919-24-6 ]
  • [ 943321-85-5 ]
YieldReaction ConditionsOperation in experiment
80% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 70℃; for 4h; To a solution of <strong>[13195-50-1]2-bromo-5-nitrothiophene</strong> (0.23 g, 1 .08 mmole) in dioxane (9 imL) and H2O (1 .8 mL) was added K2CO3 (0.40 g, 4.33 mmole), tetrakistriphenylphosphine Pd(O) (0.06 g, 0.056 mmole), and 1-(phenylsulfonyl)-4- (4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-pyrrolo[2,3-b]pyridine (0.5 g, 1.29 mmole). The reaction mixture was heated to 70° C in a sealed tube for 4h. The reaction solution was concentrated under vacuum, and purified on silica gel (hexanes/EtOAc, 3:1 ) to give the title compound (400 mg, 80percent) as a brown solid: LC-MS (ES) m/z = 386 (M+1 )+.
  • 2
  • [ 13195-50-1 ]
  • [ 942919-24-6 ]
  • [ 943321-45-7 ]
YieldReaction ConditionsOperation in experiment
55% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 80℃; for 12h; To a solution of percent-bromo-2-nitrothiophene (1.08 g, 5.2 mmole) in dioxane (40 mL) and H2O (8 mL) was added K2CO3 (2.15 g, 16.74 mmole), tetrakistriphenylphosphine Pd(O) (0.60 g, 0.52 mmole), and 1-(phenylsulfonyl)-3- (4,4,5,5-tetramethyl-1 J3.2-dioxaborolan-2-yl)-1H-pyrro.o[2,3-ib]pyridine (2.0 g, 5.2 mmole). The reaction mixture was heated to 80° C in a sealed tube for 12h. The reaction solution was poured onto H2O (100 mL) and extracted with DCM. The organics were dried (Na2SO4), concentrated under vacuum, and purified on silica gel (hexanes/EtOAc, 1 :1 ) to give the title compound (1.1 g, 55percent) as a tan foam: LC- MS (ES) m/z = 386.
 

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