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Chemical Structure| 944263-65-4 Chemical Structure| 944263-65-4

Structure of Demiditraz
CAS No.: 944263-65-4

Chemical Structure| 944263-65-4

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Product Details of [ 944263-65-4 ]

CAS No. :944263-65-4
Formula : C13H16N2
M.W : 200.28
SMILES Code : C[C@H](C1=NC=CN1)C2=CC=CC(C)=C2C

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Application In Synthesis of [ 944263-65-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 944263-65-4 ]

[ 944263-65-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 944263-65-4 ]
  • [ 1700-31-8 ]
  • 1-[3-(Benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 20℃; for 48h; To a mixture of the compound of Example 58 (90 mg, 0.45 mmol) and caesium carbonate (244 mg, 0.75 mmol) in 1-methyl-2-pyrrolidinone (1 ml) was added <strong>[1700-31-8]1-(benzyloxy)-3-(bromomethyl)benzene</strong> (139 mg, 0.50 mmol). The reaction mixture was stirred at room temperature for 48 h and then filtered through a Whatman PTFE filter tube (5 mum).The filtrate was purified by automated preparative liquid chromatography (Gilson system, 150 mm.x.22.4 mm LUNA C18(2) 5 mum column, 20 ml/min) using an acetonitrile:water gradient [50:50 (15 min) to 98:2 (20 min)]. The appropriate fractions were combined and concentrated to give the title compound (31 mg).Experimental MH+ 397.5; expected 397.21H-NMR (d6-Acetone): 1.50-1.54 (3H), 2.19-2.25 (6H), 4.33-4.38 (1H), 4.65-4.70 (1H), 4.90-4.95 (1H), 4.98-5.00 (2H), 6.46-6.51 (2H), 6.74-6.76 (1H), 6.84-6.98 (4H), 7.00-7.01 (1H), 7.15-7.20 (1H), 7.31-7.42 (5H)Rhip. Funct. ED100 mg/cm2<=10
 

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