Home Cart Sign in  
Chemical Structure| 944279-31-6 Chemical Structure| 944279-31-6

Structure of 944279-31-6

Chemical Structure| 944279-31-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 944279-31-6 ]

CAS No. :944279-31-6
Formula : C13H17BrFNO2
M.W : 318.18
SMILES Code : FC1=CC(Br)=CC=C1OCCCN2CCOCC2
MDL No. :MFCD22989488

Safety of [ 944279-31-6 ]

Application In Synthesis of [ 944279-31-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 944279-31-6 ]

[ 944279-31-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 944279-31-6 ]
  • [ 944279-32-7 ]
YieldReaction ConditionsOperation in experiment
84%
Stage #1: With iodine; magnesium In tetrahydrofuran at 90℃; for 1 h;
Stage #2: With Trimethyl borate In tetrahydrofuran at -78℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water for 0.5 h;
A solution of 4-[3-(4-bromo-2-fluoro-phenoxy)-propyl]-morpholine from step 2 (5.08g, 15.96mmol) in THF (10ml) was added drop-wise to a stirred slurry of Mg (582mg, 1.5eq) in THF (2ml) and a small crystal of iodine. After addition, the mixture was heated to 90° for Ih. The grey mixture was cooled to -78° trimethylborate (1.2eq, 2.15ml) added drop-wise and allowed to warm overnight. 2N HCl (aq, 60ml) was added and stirred for 30 min before being extracted into ether (2x50ml). Then triethylamine was added to the aqueous layer and extracted with ethyl acetate and ether. The combined organic phases were dried, concentrated to give a brown oil (3.8g, 84percent). The product was used crude without further purification. 1H NMR (D6-DMSO) δ 8.08 (2H, broad s), 7.55 (IH, t, J 8.75Hz), 7.15 (2H, m), 4.04 (2H, t, J 6.25Hz ), 3.57 (4H, m), 2.37 (6H, m), 1.84 (2H, m). LC-MS: rt 1.95 m/z 284 ES+.
References: [1] Patent: WO2007/80401, 2007, A1, . Location in patent: Page/Page column 53-54.
 

Historical Records

Technical Information

Categories