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[ CAS No. 94512-73-9 ] {[proInfo.proName]}

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Chemical Structure| 94512-73-9
Chemical Structure| 94512-73-9
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Product Details of [ 94512-73-9 ]

CAS No. :94512-73-9 MDL No. :MFCD01837873
Formula : C14H10Br2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 354.04 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 94512-73-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94512-73-9 ]

[ 94512-73-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 334769-80-1 ]
  • [ 94512-73-9 ]
  • [ 1335316-41-0 ]
YieldReaction ConditionsOperation in experiment
76.7% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20℃; for 3h; To a mixture of 2-bromo-1 -[4-(4-bromophenyl)phenyl]ethanone (735.3 mg, 2mmol), (2S,5S)-1 -tert-butoxycarbonyl-5-methyl-pyrrolidine-2-carboxylic acid (500 mg, 2.18 mmol) in acetonitrile (10 ml) (suspension) is added DIPEA (380 muIota_, 2.18 mmol). The reaction mixture is stirred at rt for 3 hours, diluted with EtOAc and H20. The organic phase is washed with brine, dried over Na2S04, filtered and concentrated. The residue is purified by flash column chromatography on silica gel (0 to 30percent EtOAc in Hexanes) to afford 2-[2-[4-(4- bromophenyl)phenyl]-2-oxo-ethyl]-1 -tert-butyl-(2S,5S)-5-methylpyrrolidine-1 ,2- dicarboxylate (0.8 g, 76.7percent) as a white solid.
  • 2
  • [ 364750-81-2 ]
  • [ 94512-73-9 ]
  • [ 1335316-22-7 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20℃; for 4h; To a solution of (2S,4S)-1 -tert-butoxycarbonyl-4-methyl-pyrrolidine-2- carboxylic acid (437 mg, 1 .905 mmol) in acetonitrile (6 mL) is added 2-bromo- 1 - [4-(4-bromophenyl)phenyl]ethanone ( 693 mg, 1 .732 mmol) and DIPEA ( 0.332 mL, 1 .905 mmol). The reaction mixture is stirred at room temperature for 4 hours and diluted with EtOAc and washed with brine (3 x 2 mL). The organic layer is concentrated to dryness, azeotroped with toluene (5 mL), and purified by flash column chromatography on silica gel (6 to 50 percent EtOAc in hexanes) to give (2S,4S)-2-(2-(4'-bromobiphenyl-4-yl)-2-oxoethyl) 1 -tert-butyl 4- methylpyrrolidine-1 ,2-dicarboxylate (870 mg, 1.732 mmol).
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Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction
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