Home Cart Sign in  
Chemical Structure| 952511-15-8 Chemical Structure| 952511-15-8

Structure of 952511-15-8

Chemical Structure| 952511-15-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 952511-15-8 ]

CAS No. :952511-15-8
Formula : C10H14N2O2
M.W : 175.19
SMILES Code : N=C(C1=CC=CC2=C1C=CN2)NO
MDL No. :MFCD22195548

Safety of [ 952511-15-8 ]

Application In Synthesis of [ 952511-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 952511-15-8 ]

[ 952511-15-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 952511-15-8 ]
  • [ 67515-55-3 ]
  • [ 952511-33-0 ]
YieldReaction ConditionsOperation in experiment
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 20℃; for 19h;Heating / reflux; A suspension of N2-hydroxy-1H-indole-4-carboxamide (1.00 g), <strong>[67515-55-3]4-fluoro-3-(trifluoromethyl)benzoic acid</strong> (1.19 g), and EDCI/HCl (1.32 g) in dioxane (30 ml) was stirred at room temperature for 1 hour, and further heated under reflux for 18 hours. The reaction mixture was concentrated under reduced pressure, chloroform and water were added thereto, followed by stirring. The insolubles were collected by filtration. The organic layer of the mother liquor was washed with water, dried over anhydrous MgSO4 and then filtered, and the filtrate was concentrated under reduced pressure. The insolubles collected by filtration, together with the mother liquor, was purified by silica gel chromatography (n-hexane:EtOAc=80:20). To the objective substance was added acetone, followed by dissolving under heating, and addition with n-hexane, and the precipitated solid was collected by filtration to obtain 4-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indole (391 mg) as a white solid.
  • 2
  • [ 952511-15-8 ]
  • [ 67515-55-3 ]
  • [ 952511-35-2 ]
YieldReaction ConditionsOperation in experiment
With diisopropyl-carbodiimide; In tetrahydrofuran; at -15 - -5℃; for 3h; A solution of N2-hydroxy-1H-indole-4-carboxamide (3.42 g) and <strong>[67515-55-3]4-fluoro-3-(trifluoromethyl)benzoic acid</strong> (4.07 g) in THF (70 ml) was cooled to -10C or lower, and added with DIC (3.7 ml). After stirring at -15 to -5C for 3 hours, the reaction mixture was concentrated under reduced pressure. The residue was suspended in chloroform, and then the insolubles were collected by filtration. The obtained powders were purified by silica gel chromatography (n-hexane:EtOAc=50:50) to obtain N2-[4-fluoro-3-(trifluoromethyl)benzoyl]oxy}-1H-indole-4-carboxamide (8.40 g) as a white solid.
 

Historical Records

Technical Information

Categories