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Chemistry
Heterocyclic Building Blocks
Benzofurans
2,3-Dihydrobenzofuran-7-sulfonyl chloride
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Benzofurans
Chlorides Sulfonyl Chlorides

[ CAS No. 953408-82-7 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 953408-82-7
Chemical Structure| 953408-82-7
Structure of 953408-82-7 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 953408-82-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 953408-82-7 ]

Product Details of [ 953408-82-7 ]

CAS No. :953408-82-7 MDL No. :MFCD11109309
Formula : C8H7ClO3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 218.66 Pubchem ID :-
Synonyms :

Safety of [ 953408-82-7 ]

Signal Word:Danger Class:8
Precautionary Statements:P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 UN#:3261
Hazard Statements:H314-H290 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 953408-82-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 953408-82-7 ]

[ 953408-82-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 496-16-2 ]
  • [ 953408-82-7 ]
YieldReaction ConditionsOperation in experiment
94% In 1,2-dichloro-ethane 1 Preparation of 7-chlorosulfonyl-2,3-dihydrobenzo[b]furan (2) Example 1 Preparation of 7-chlorosulfonyl-2,3-dihydrobenzo[b]furan (2) 2,3-Dihydrobenzo[b]furan (1) (Aldrich, 5.6 mL, 50 mmol) was added to a suspension of sulfur trioxide-dimethylformamide complex (Aldrich, 9.2 g, 60 mmol) in 1,2-dichloroethane (Aldrich, 20 mL). After being heated at 80° C. for 1 hour, the reaction mixture was cooled to room temperature, and thionyl chloride (Aldrich, 4.5 mL, 57 mmol) was introduced. The reaction mixture was then heated at 70° C. for 3 hours. After cooling down to room temperature, the reaction mixture was poured into ice water (100 mL) which was extracted with ether (3*30 mL). Combined organic layers were washed with brine, then dried (MgSO4). Removal of solvent under vacuum yielded a light yellow solid (10.2 g, 94%). TLC Rf 0.45 (9:1 of hexane-ethyl acetate); MS (electrospray) 219 (M+1); 1H NMR (CDCl3) δ3.35 (t, 2H, J=7.2 Hz), 4.78 (t, 2H, J=7.2 Hz), 6.92 (d, 1H, J=3.1 Hz), 7.82 (s, 1H), 7.83 (d, 1H, J=3.1 Hz).
Reference： [1]Current Patent Assignee: NANJING XINJIEKOU DEPARTMENT STORE CO., LTD. - US6541467, 2003, B1
  • 2
  • [ 206347-30-0 ]
  • [ 953408-82-7 ]
YieldReaction ConditionsOperation in experiment
2. Synthesis of 2,3-dihydrobenzofuran-7-sulfonyl chloride; n-Butyllithium (23 mmol) was added dropwise to a solution of 1,3-dibromo-2-(2-bromoethoxy)benzene (21.8 mmol) in tetrahydrofuran (100 mL) at -100 C. and the reaction mixture was maintained for 30 min. n-Butyllithium (23 mmol) was added dropwise and the reaction mixture was maintained at -100 C. for an additional 60 min. Sulfur dioxide (43.8 mmol) was added and the reaction mixture was maintained for 2 h between -100 and -85 C. The reaction mixture was diluted with hexane (100 mL) and the precipitated solids were collected by filtration. The solid was suspended in dichloromethane (100 mL) at 0 C. and N-chlorosuccinamide (24.6 mmol) was added in several batches. The reaction mixture was maintained for 60 min at 0 C. and was diluted with dichloromethane (100 mL). The reaction mixture was washed with (2 M) sodium hydrogen sulfate (2×150 mL) and brine (3×100 mL), was dried (sodium sulfate), and was concentrated. The residue was purified by Flash chromatography (1/50 ethyl acetate/petroleum ether) to provide 2,3-dihydrobenzofuran-7-sulfonyl chloride in 51% yield as a light yellow solid. Data: 1H NMR: (CDCl3) delta 3.35 (t, 2H), 4.92 (t, 2H), 6.96 (t, 1H), 7.54 (s, 1H), 7.64 (d, 1H). LC/MS (ES) m/z 283 [C13H18N2O3S+H]+.
Reference： [1]Patent: US2010/16297,2010,A1 .Location in patent: Page/Page column 34
  • 3
  • [ 953408-82-7 ]
  • [ 535170-20-8 ]
  • C19H20F2N2O5S [ No CAS ]
Reference： [1]Bulletin of the Korean Chemical Society,2016,vol. 37,p. 1632 - 1637

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