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Chemical Structure| 953408-82-7 Chemical Structure| 953408-82-7

Structure of 953408-82-7

Chemical Structure| 953408-82-7

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Product Details of [ 953408-82-7 ]

CAS No. :953408-82-7
Formula : C8H7ClO3S
M.W : 218.66
SMILES Code : O=S(C1=C(OCC2)C2=CC=C1)(Cl)=O
MDL No. :MFCD11109309

Safety of [ 953408-82-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H290
Precautionary Statements:P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 953408-82-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 953408-82-7 ]

[ 953408-82-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 206347-30-0 ]
  • [ 953408-82-7 ]
YieldReaction ConditionsOperation in experiment
2. Synthesis of 2,3-dihydrobenzofuran-7-sulfonyl chloride; n-Butyllithium (23 mmol) was added dropwise to a solution of 1,3-dibromo-2-(2-bromoethoxy)benzene (21.8 mmol) in tetrahydrofuran (100 mL) at -100 C. and the reaction mixture was maintained for 30 min. n-Butyllithium (23 mmol) was added dropwise and the reaction mixture was maintained at -100 C. for an additional 60 min. Sulfur dioxide (43.8 mmol) was added and the reaction mixture was maintained for 2 h between -100 and -85 C. The reaction mixture was diluted with hexane (100 mL) and the precipitated solids were collected by filtration. The solid was suspended in dichloromethane (100 mL) at 0 C. and N-chlorosuccinamide (24.6 mmol) was added in several batches. The reaction mixture was maintained for 60 min at 0 C. and was diluted with dichloromethane (100 mL). The reaction mixture was washed with (2 M) sodium hydrogen sulfate (2×150 mL) and brine (3×100 mL), was dried (sodium sulfate), and was concentrated. The residue was purified by Flash chromatography (1/50 ethyl acetate/petroleum ether) to provide 2,3-dihydrobenzofuran-7-sulfonyl chloride in 51% yield as a light yellow solid. Data: 1H NMR: (CDCl3) delta 3.35 (t, 2H), 4.92 (t, 2H), 6.96 (t, 1H), 7.54 (s, 1H), 7.64 (d, 1H). LC/MS (ES) m/z 283 [C13H18N2O3S+H]+.
 

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