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CAS No. : | 95484-17-6 | MDL No. : | MFCD26516661 |
Formula : | C12H15NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | QVWVVHRNMKYYBJ-UHFFFAOYSA-N |
M.W : | 221.25 | Pubchem ID : | 11368024 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With sodium cyanoborohydride In methanol at 50℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In benzene for 17h; Heating; Yield given; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | In dichloromethane at 20℃; for 14h; | |
83% | With Nafion(R) SAC-13 In acetonitrile at 20℃; for 12h; | |
76% | at 20℃; |
60% | With dichloro bis(acetonitrile) palladium(II) In dichloromethane at 20℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 81% 2: 18% | In acetonitrile at 20℃; for 4h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 4-N-(benzyloxycarbonyl)-butan-2-one In tetrahydrofuran at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -60℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 77 percent / tetrahydrofuran / -78 °C 2: 85 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 83 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C 2: 77 percent / tetrahydrofuran / -78 °C 3: 85 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 92 percent / Na2CO3 / H2O 2: 83 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C 3: 77 percent / tetrahydrofuran / -78 °C 4: 85 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 71 percent / m-CPBA / CH2Cl2 / 24 h / Heating 3.1: 80 percent / BF3*Et2O / CH2Cl2 / 2 h / -78 °C 4.1: 100 percent / hydrogen / Pd-C / ethanol / 12 h / 760 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C 3.1: 83 percent / Et3N / CH2Cl2 4.1: 90 percent / K2CO3 / ethanol 5.1: NaH / dimethylformamide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C 3.1: 83 percent / Et3N / CH2Cl2 4.1: 90 percent / K2CO3 / ethanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 71 percent / m-CPBA / CH2Cl2 / 24 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 71 percent / m-CPBA / CH2Cl2 / 24 h / Heating 3.1: 80 percent / BF3*Et2O / CH2Cl2 / 2 h / -78 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 71 percent / m-CPBA / CH2Cl2 / 24 h / Heating 3.1: 80 percent / BF3*Et2O / CH2Cl2 / 2 h / -78 °C 4.1: 100 percent / hydrogen / Pd-C / ethanol / 12 h / 760 Torr 5.1: 92 percent / pyridine / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 20 °C 2.1: AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C 3.1: Et3N / CH2Cl2 4.1: DBU |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 20 °C 2.1: AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 20 °C 2.1: AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C 3.1: 83 percent / Et3N / CH2Cl2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 20 °C 2.1: AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C 3.1: Et3N / CH2Cl2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; diethyl ether at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With toluene-4-sulfonic acid In methanol at 45℃; for 3.5h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)] In dichloromethane for 1.5h; Reflux; Inert atmosphere; diastereoselective reaction; |
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