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Chemical Structure| 959137-49-6 Chemical Structure| 959137-49-6

Structure of 959137-49-6

Chemical Structure| 959137-49-6

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Product Details of [ 959137-49-6 ]

CAS No. :959137-49-6
Formula : C11H10ClN3O
M.W : 235.67
SMILES Code : O=C1N(C2CC2)C(C3=CC=C(Cl)C=C3)=NN1
MDL No. :MFCD29921132

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Application In Synthesis of [ 959137-49-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 959137-49-6 ]

[ 959137-49-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 959137-49-6 ]
  • [ 85822-16-8 ]
  • [ 1228560-65-3 ]
YieldReaction ConditionsOperation in experiment
58% With sodium hydride; In N,N-dimethyl-formamide; paraffin; at 0 - 20℃; for 12h; Example 14A 4-[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]sulphonyl}benzenecarbaldehyde An amount of 300 mg (1.27 mmol) of the compound from Example 4A was dissolved in 3 ml of DMF and admixed at 0 C. with 56 mg (1.40 mmol) of sodium hydride (60% in liquid paraffin). The mixture was stirred at this temperature for 30 minutes thereafter and then admixed with 260 mg (1.27 mmol) of 4-formylbenzenesulphonyl chloride. The mixture was warmed to room temperature and thereafter left with stirring at room temperature for 12 hours. The reaction mixture was admixed with 15 ml of water, and the precipitated solid was isolated by suction filtration, washed with a little water and dried in a high vacuum. This gave 351 mg (58% of theory) of the target compound. LC-MS [Method 3]: Rt=2.36 min; MS [ESIpos]: m/z=404 (M+H)+
 

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