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Quality Control of [ 97980-71-7 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 97980-71-7 ]

CAS No. :	97980-71-7	MDL No. :	MFCD00708020
Formula :	C₁₇H₁₂O₆	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	312.27	Pubchem ID :	-
Synonyms :

Safety of [ 97980-71-7 ]

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Application In Synthesis of [ 97980-71-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 97980-71-7 ]

[ 97980-71-7 ] Synthesis Path-Downstream 1~19

1
[ 97980-71-7 ]
[ 629-96-9 ]
[ 1217342-37-4 ]

Yield	Reaction Conditions	Operation in experiment
33%	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 80 - 90℃; for 12h;

Reference： [1]Location in patent: experimental part Lv, Peng-Cheng; Wang, Kai-Rui; Li, Qing-Shan; Chen, Jin; Sun, Juan; Zhu, Hai-Liang [Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 3, p. 1117 - 1123]

2
[ 2150-45-0 ]
[ 97980-71-7 ]
2-hydroxy-6-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

3
[ 97980-71-7 ]
[ 2150-46-1 ]
[ 1235837-61-2 ]

Yield	Reaction Conditions	Operation in experiment
74%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

4
[ 97980-71-7 ]
[ 391-92-4 ]
[ 1235837-69-0 ]

Yield	Reaction Conditions	Operation in experiment
75%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

5
[ 97980-71-7 ]
[ 4068-78-4 ]
[ 1235837-67-8 ]

Yield	Reaction Conditions	Operation in experiment
73%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

6
[ 97980-71-7 ]
[ 22717-57-3 ]
[ 1235837-63-4 ]

Yield	Reaction Conditions	Operation in experiment
71%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;	4.3.3. General procedure for the preparation of compounds 5a-5t General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]Location in patent: experimental part Lv, Peng-Cheng; Cai, Tian-Tian; Qian, Yong; Sun, Juan; Zhu, Hai-Liang [European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 393 - 398]

7
[ 97980-71-7 ]
[ 4670-56-8 ]
[ 1235837-71-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;	4.3.3. General procedure for the preparation of compounds 5a-5t General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

8
[ 97980-71-7 ]
[ 6342-70-7 ]
[ 1235837-77-0 ]

Yield	Reaction Conditions	Operation in experiment
73%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

9
[ 97980-71-7 ]
[ 22717-56-2 ]
[ 1235837-75-8 ]

Yield	Reaction Conditions	Operation in experiment
74%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

10
[ 97980-71-7 ]
[ 22717-55-1 ]
[ 1235837-73-6 ]

Yield	Reaction Conditions	Operation in experiment
71%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

11
[ 97980-71-7 ]
[ 52159-67-8 ]
3-chloro-2-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12.0h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

12
[ 97980-71-7 ]
[ 176750-70-2 ]
2-chloro-6-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20.0℃; for 12.0h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

13
[ 97980-71-7 ]
[ 28165-45-9 ]
3-bromo-2-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

14
[ 97980-71-7 ]
[ 72373-81-0 ]
2-fluoro-6-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 12h;	General procedure: A solution of compound 3, substituted methyl salicylate (4a-4t), 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (EDC.HCl), N-Hydroxybenzotriazole (HOBt) and 4-dimethylaminopyridine (DMAP) in DMF (50 mL) was stirred for 12 h at room temperature. Then, compounds 5a-5t were obtained by subsequent purification with flash chromatography (acetate: petroleum ether = 1:5-1:2).

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 393 - 398

15
[ 98198-48-2 ]
[ 97980-71-7 ]
N-(4-bromo-3-methylphenyl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%		General procedure: To a solution of the carboxylic acid 7 (31.4 mg, 0.1 mmol) in anhydrous CH2Cl2 was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (5.0 equiv) and 4-dimethylaminopyridine (1.0 equiv) at 0 C. The reaction mixture was stirred for 10 min at the same temperature. To the reaction mixture was added amine (3.0 equiv) and then the reaction mixture was slowly warmed to room temperature. After 12 hours at the same temperature, the reaction mixture was diluted with CH2Cl2 and washed with aqueous NH4Cl. The organic layer was dried over MgSO4. The mixture was concentrated at reduced pressure. The residue was purified by flash chromatography on silica gel (CH2Cl2/methanol, 15:1) to give desired amide 12 (32.7 mg, 70%).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 4324 - 4327

16
[ 97980-71-7 ]
[ 21717-95-3 ]
[ 1447463-72-0 ]

Yield	Reaction Conditions	Operation in experiment
63%		General procedure: To a solution of the carboxylic acid 7 (31.4 mg, 0.1 mmol) in anhydrous CH2Cl2 was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (5.0 equiv) and 4-dimethylaminopyridine (1.0 equiv) at 0 C. The reaction mixture was stirred for 10 min at the same temperature. To the reaction mixture was added amine (3.0 equiv) and then the reaction mixture was slowly warmed to room temperature. After 12 hours at the same temperature, the reaction mixture was diluted with CH2Cl2 and washed with aqueous NH4Cl. The organic layer was dried over MgSO4. The mixture was concentrated at reduced pressure. The residue was purified by flash chromatography on silica gel (CH2Cl2/methanol, 15:1) to give desired amide 12 (32.7 mg, 70%).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 4324 - 4327

17
[ 2038-03-1 ]
[ 97980-71-7 ]
[ 1447463-78-6 ]

Yield	Reaction Conditions	Operation in experiment
68%	Stage #1: 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 4-(2-AMINOETHYL)MORPHOLINE In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;	General Procedure (GP) for Synthesis Amide General procedure: To a solution of the carboxylic acid 7 (31.4 mg, 0.1 mmol) in anhydrous CH2Cl2 was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (5.0 equiv) and 4-dimethylaminopyridine (1.0 equiv) at 0 °C. The reaction mixture was stirred for 10 min at the same temperature. To the reaction mixture was added amine (3.0 equiv) and then the reaction mixture was slowly warmed to room temperature. After 12 hours at the same temperature, the reaction mixture was diluted with CH2Cl2 and washed with aqueous NH4Cl. The organic layer was dried over MgSO4. The mixture was concentrated at reduced pressure. The residue was purified by flash chromatography on silica gel (CH2Cl2/methanol, 15:1) to give desired amide 12 (32.7 mg, 70%).
63.4%	With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In dichloromethane at 60℃;

Reference： [1]Choe, Hyeonjeong; Kim, Jieun; Hong, Sungwoo [Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 15, p. 4324 - 4327]
[2]Xiao, Zhu-Ping; Wei, Wei; Liu, Qi; Wang, Peng-Fei; Luo, Xing; Chen, Fang-Yuan; Cao, Yang; Huang, Hong-Xia; Liu, Mi-Mi; Zhu, Hai-Liang [RSC Advances, 2017, vol. 7, # 11, p. 6193 - 6201]

18
[ 5805-57-2 ]
[ 97980-71-7 ]
N-((1H-benzo[d]imidazol-2-yl)methyl)-2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 1.25h;	General procedure: To a stirring solution of appropriately substituted 11 or 12 (0.76 mmol) in DMF at RT, HATU (0.83 mmol) and diisopropylethylamine (2.29 mmol) were added. Appropriately, substituted amine (0.76 mmol) was added after 15 min and stirring continued for another 1 h at rt. The reaction was monitored by TLC and then poured into ice water with stirring. On complete consumption of reactants, the reaction mixture was cooled to room temperature. The so-formed precipitate was filtered off and chromatographed on a silica gel (Hexane/EtOAc) on silica gel (100?200 mesh).

Reference： [1]Medicinal Chemistry Research,2015,vol. 24,p. 2656 - 2669

19
[ 7720-39-0 ]
[ 97980-71-7 ]
2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(1H-imidazol-2-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 1.25h;	General procedure: To a stirring solution of appropriately substituted 11 or 12 (0.76 mmol) in DMF at RT, HATU (0.83 mmol) and diisopropylethylamine (2.29 mmol) were added. Appropriately, substituted amine (0.76 mmol) was added after 15 min and stirring continued for another 1 h at rt. The reaction was monitored by TLC and then poured into ice water with stirring. On complete consumption of reactants, the reaction mixture was cooled to room temperature. The so-formed precipitate was filtered off and chromatographed on a silica gel (Hexane/EtOAc) on silica gel (100-200 mesh).

Reference： [1]Medicinal Chemistry Research,2015,vol. 24,p. 2656 - 2669

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Code	Phrase
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P378
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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
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P401
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P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 97980-71-7 ] {[proInfo.proName]}

Quality Control of [ 97980-71-7 ]

Related Doc. of [ 97980-71-7 ]

Product Details of [ 97980-71-7 ]

Safety of [ 97980-71-7 ]

Application In Synthesis of [ 97980-71-7 ]

[ 97980-71-7 ] Synthesis Path-Downstream 1~19

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry