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Structure of 98081-84-6

Chemical Structure| 98081-84-6

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Product Details of [ 98081-84-6 ]

CAS No. :98081-84-6
Formula : C10H8ClNO2
M.W : 209.63
SMILES Code : O=C(C(N1)=CC2=C1C=C(Cl)C=C2)OC
MDL No. :MFCD04966992
InChI Key :HHDCCGVOJXWGEU-UHFFFAOYSA-N
Pubchem ID :4715032

Safety of [ 98081-84-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280

Application In Synthesis of [ 98081-84-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 98081-84-6 ]

[ 98081-84-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 98081-84-6 ]
  • [ 53590-58-2 ]
YieldReaction ConditionsOperation in experiment
50% With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 5 h; Cooling with ice General procedure: A solution of indole-2-carboxylate 11 (1 mmol) in THF (10 mL)was added dropwise to a suspension of LiAlH4 (0.8 mmol) in THF(20 mL) under cooling with ice-water. After stirring at rt for 5 h, thereaction mixture was quenched with water, and then was filtratedthrough a Celite pad. The filtrate was extracted with EtOAc. Theorganic layer was washed with brine, dried over Na2SO4, andevaporated in vacuo. The residue was purified by column chromatography using EtOAc-hexane as an eluent to give thealcohol 12.
References: [1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577.
 

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