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Chemical Structure| 14667-47-1 Chemical Structure| 14667-47-1
Chemical Structure| 14667-47-1

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Product Details of Methyl 2-aminonicotinate

CAS No. :14667-47-1
Formula : C7H8N2O2
M.W : 152.15
SMILES Code : C1=CC=NC(=C1C(OC)=O)N
MDL No. :MFCD00128872
InChI Key :NZZDEODTCXHCRS-UHFFFAOYSA-N
Pubchem ID :351633

Safety of Methyl 2-aminonicotinate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Methyl 2-aminonicotinate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 14667-47-1 ]
  • Downstream synthetic route of [ 14667-47-1 ]

[ 14667-47-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 14667-47-1 ]
  • [ 50735-34-7 ]
YieldReaction ConditionsOperation in experiment
99% With bromine; sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 1 h; To a stirred solution of 2-amino-nicotinic acid methyl ester (2 g, 13.15 mmol) and sodium bicarbonate (2.2 g, 26.31 mmol) in DCM (30 mL) is added a solution of bromine (1.01 mL in DCM (20 mL) drop wise at 0° C.
The reaction mixture is stirred at room temperature for 1 hour.
The reaction mixture is quenched with sodium bisulfite solution (50 mL) and extracted with DCM (2*40 mL).
The combined organic layers are washed with brine (40 mL), dried over sodium sulphate, filtered, and evaporated under reduced pressure to give the title compound as a yellow solid (3 g, 99percent). LCMS m/z (79Br/81Br) 231/233 (M+H)+.
References: [1] Patent: US2017/29420, 2017, A1, . Location in patent: Paragraph 0034.
 

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