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Chemical Structure| 56-65-5 Chemical Structure| 56-65-5

Structure of ATP
CAS No.: 56-65-5

Chemical Structure| 56-65-5

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ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.

Synonyms: Adenosine triphosphate; Adenosine 5'-triphosphate; Triphosphoric acid adenosine ester

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Ard, Adam ; Cruz-Cortés, Carlos ; Gan, Xinmin ; Guerrero-Serna, Guadalupe ; White, Andrew D ; Clasby, Martin C , et al.

Abstract: Heart failure (HF) remains a major public health burden, with current therapies focused primarily on symptom management. Impaired activity of the cardiac Ca2+ pump SERCA2a is a hallmark of HF and a promising therapeutic target, but limited structural data have hindered small-molecule development. Here, we report a comprehensive structure−activity relationship (SAR) investigation of small-molecule SERCA2a activators, beginning with natural product hits and progressing through iterative optimization of three pharmacophoric regions. This effort produced the largest collection of SERCA2a modulators to date-including 20 activators, 8 dual effectors, and 6 inhibitors. Several indoline, benzofuran, and benzodioxole analogs emerged as potent activators, increasing ATPase activity by ∼57% (EC50 = 0.7−9 μM). Notably, SERCA2a activation was inversely correlated with Ca2+ affinity, suggesting that SERCA2a stimulation occurs at the expense of Ca2+ binding. In summary, these findings identify key structural features that drive SERCA2a activity and establish a framework for developing next-generation SERCA2a-targeted therapies.

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Stimson, Ryan ;

Abstract: RNA being composed of multiple covalently linked nucleotides is thought to have been a precursor to life circa 4.3-3.8 billion years ago. Non-enzymatically formed adenosine monophosphate (AMP), more specifically, is a vitally important subtopic of the self-assembly of the first RNA sequence. The goal of this study was to synthesize AMP non-enzymatically under benign conditions that are likely to have existed on early Earth. In this experiment, 3’,5’-cAMP was successfully formed using wet-dry cycles at 80°C paired with the minerals zeolite beta, hydroxyapatite, and aerosil 300 in the presence of adenosine, urea, and pyrophosphate. A nuclear magnetic resonance spectrometer was used to characterize the products of each experiment to determine if any adenosine nucleotides were formed. Decreasing the pH and having a higher number of wet-dry cycles results in a higher amount of cAMP formation.

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Product Details of ATP

CAS No. :56-65-5
Formula : C10H16N5O13P3
M.W : 507.18
SMILES Code : O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(O)(OP(O)(O)=O)=O)=O
Synonyms :
Adenosine triphosphate; Adenosine 5'-triphosphate; Triphosphoric acid adenosine ester
MDL No. :MFCD00065467
InChI Key :ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Pubchem ID :5957

Safety of ATP

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Adenosine 5'-triphosphate (ATP) is a crucial component of energy storage and metabolism within the body. It not only provides the metabolic energy required for operating metabolic pumps but also acts as a coenzyme in various cellular processes. Additionally, ATP plays a significant role as an endogenous signaling molecule in immune responses and inflammation[1].[2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.86mL

1.97mL

0.99mL

19.72mL

3.94mL

1.97mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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