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Chemical Structure| 206361-99-1 Chemical Structure| 206361-99-1

Structure of Darunavir
CAS No.: 206361-99-1

Chemical Structure| 206361-99-1

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Darunavir is a protease inhibitor which acts on the HIV aspartyl protease.

Synonyms: UIC-94017; TMC114

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Product Citations

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Elgammal, Yehia ; Salama, Ehab A ; Seleem, Mohamed N ;

Abstract: Candida auris is an invasive fungal pathogen, representing a global public health threat. It is characterized by high mortality rates among infected individuals, significant antifungal resistance, and a remarkable ability to persist in healthcare environments. While amphotericin B is one of the most powerful antifungal agents for treating Candida infections, approximately 30% of C. auris isolates demonstrate resistance to it. Thus, the development of novel antifungal therapies is vital for tackling its life-threatening infections. In this study, we identified four HIV protease inhibitors (atazanavir, saquinavir, lopinavir and ritonavir) as strong potentiators of amphotericin B against C. auris. A synergistic effect between HIV protease inhibitors and amphotericin B was observed against 15 C. auris isolates with fractional inhibitory concentration index (FICI) ranging from 0.09 to 0.50. Additionally, the combinations between HIV protease inhibitors and amphotericin B showed fungicidal effect, significantly reducing the viable cell count in the time-kill assay within 6 hours. Furthermore, the combinations inhibited biofilm formation of C. auris by 60–75% and exhibited a remarkable suppression of C. albicans hyphae. The in vivo treatment with HIV protease inhibitors combined with amphotericin B resulted in a significant reduction of C. auris colony-forming units (CFU) by 1.7–2.6 Log10 in the C. elegans model. These findings suggest that HIV protease inhibitors, in combination with amphotericin B, are promising candidates for the development of novel antifungal drugs to treat Candida infections.

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Nour M. Alkashef ; Mohamed N. Seleem ;

Abstract: Cryptococcosis is a fungal infection that is becoming increasingly prevalent worldwide, particularly among individuals with compromised immune systems, such as HIV patients. Amphotericin B (AmB) is the first-line treatment mainly combined with flucytosine. The scarcity and the prohibitive cost of this regimen urge the use of fluconazole as an alternative, leading to increased rates of treatment failure and relapses. Therefore, there is a critical need for efficient and cost-effective therapy to enhance the efficacy of AmB. In this study, we evaluated the efficacy of the HIV protease inhibitors (PIs) to synergize the activity of AmB in the treatment of cryptococcosis. Five PIs (ritonavir, atazanavir, saquinavir, lopinavir, and nelfinavir) were found to synergistically potentiate the killing activity of AmB against Cryptococcus strains with ƩFICI ranging between 0.09 and 0.5 against 20 clinical isolates. This synergistic activity was further confirmed in a time-kill assay, where different AmB/PIs combinations exhibited fungicidal activity within 24 hrs. Additionally, PIs in combination with AmB exhibited an extended post-antifungal effect on treated cryptococcal cells for approximately 10 hrs compared to 4 hours with AmB alone. This promising activity against cryptococcal cells did not exhibit increased cytotoxicity towards treated kidney cells, ruling out the risk of drug combination-induced nephrotoxicity. Finally, we evaluated the efficacy of AmB/PIs combinations in the Caenorhabditis elegans model of cryptococcosis, where these combinations significantly reduced the fungal burden of the treated nematodes by approximately 2.44 Log10 CFU (92.4%) compared to the untreated worms and 1.40 Log10 ((39.4%) compared to AmB alone. The cost-effectiveness and accessibility of PIs in resource-limited geographical areas compared to other antifungal agents, such as flucytosine, make them an appealing choice for combination therapy.

Johnston, Nikki ; Samuels, Tina L. ; Goetz, Christopher J. ; Arnold, Leggy A. ; Smith, Brian C. ; Seabloom, Donna , et al.

Abstract: Objective: More than 20% of the US population suffers from laryngopharyngeal reflux. Although dietary/lifestyle modifications and alginates provide benefit to some, there is no gold standard medical therapy. Increasing evidence suggests that pepsin is partly, if not wholly, responsible for damage and inflammation caused by laryngopharyngeal reflux. A treatment specifically targeting pepsin would be amenable to local, inhaled delivery, and could prove effective for endoscopic signs and symptoms associated with nonacid reflux. The aim herein was to identify small molecule inhibitors of pepsin and test their efficacy to prevent pepsin-mediated laryngeal damage in vivo. Methods: Drug and pepsin binding and inhibition were screened by high-throughput assays and crystallography. A mouse model of laryngopharyngeal reflux (mechanical laryngeal injury once weekly for 2 weeks and pH 7 solvent/pepsin instillation 3 days/week for 4 weeks) was provided inhibitor by gavage or aerosol (fosamprenavir or darunavir; 5 days/week for 4 weeks; n = 3). Larynges were collected for histopathologic analysis. Results: HIV protease inhibitors amprenavir, ritonavir, saquinavir, and darunavir bound and inhibited pepsin with IC50 in the low micromolar range. Gavage and aerosol fosamprenavir prevented pepsin-mediated laryngeal damage (i.e., reactive epithelia, increased intraepithelial inflammatory cells, and cell apoptosis). Darunavir gavage elicited mild reactivity and no discernable protection; aerosol protected against apoptosis. Conclusions: Fosamprenavir and darunavir, FDA-approved therapies for HIV/AIDS, bind and inhibit pepsin, abrogating pepsin-mediated laryngeal damage in a laryngopharyngeal reflux mouse model. These drugs target a foreign virus, making them ideal to repurpose. Reformulation for local inhaled delivery could further improve outcomes and limit side effects.

Keywords: Laryngopharyngeal reflux ; LPR ; pepsin ; fosamprenavir ; darunavir

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Chufan Andrew Jin ;

Abstract: Reactive species that are employed as electrophiles in functionalization of substrates are typically prepared from native functionality such as alcohols and carboxylic acids. The addition of a pre-functionalization step of native substrates can reduce the efficiency of syntheses. These pre-functionalization reactions along with the functionalization reactions themselves proceed through polar mechanisms, limiting the scope of both functionalization and pre-functionalization reactions. Reported herein are preliminary efforts in the development of a deoxy-functionalization protocol for secondary and tertiary alcohols. The reported protocol proceeds through a derived Barton-McCombie deoxygenation mediated by a super silyl radical. Transfer of a thiocarbonate activating group to the silyl radical generates carbon radical which can be trapped out with an external sulfonyl trap, generating sulfonyl radical, which may then react with an allylic silane allowing for turnover of the radical chain.

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Alternative Products

Product Details of Darunavir

CAS No. :206361-99-1
Formula : C27H37N3O7S
M.W : 547.66
SMILES Code : O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)CC(C)C
Synonyms :
UIC-94017; TMC114
MDL No. :MFCD09260006
InChI Key :CJBJHOAVZSMMDJ-HEXNFIEUSA-N
Pubchem ID :213039

Safety of Darunavir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • HIV Protease

In Vitro:

Cell Line
Concentration Treated Time Description References
293T cells 0 to 100 μM 24 h To evaluate the cytotoxicity of nanocarriers. Results showed no significant cytotoxicity within therapeutic concentration range. PMC7749038
HCMEC/d3 cells 1 mg/ml 4 h To evaluate the uptake and permeation of nanocarriers in the BBB model. Results showed that nanoARVs with 15% DHA significantly enhanced darunavir permeation, up to 8.99-fold higher than free drug. PMC7749038
CD4+T cells 1 μM 18 h To evaluate the role of Darunavir in inhibiting HIV infection, results showed that Darunavir in combination with other drugs effectively prevented new rounds of HIV infection. PMC11829058
CD4+T cells 1 μM 18 h To evaluate the antiviral effect of Darunavir in HIV latently infected cells, results showed that Darunavir in combination with other drugs could prevent new rounds of viral infection. PMC11829058

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
ICR mice HIV brain infection model Intravenous injection 5 mg/kg Once daily for three consecutive days To evaluate drug accumulation in the brain. Results showed that nanoARVs significantly increased brain darunavir levels, 3.38- to 5.93-fold higher than free drug. PMC7749038
Hu-NSG-Tg (IL-15) mice HIV infection model Oral 175 mg/kg Once daily for 3 weeks To evaluate the antiviral effect of Darunavir in an HIV-infected mouse model, results showed that Darunavir in combination with other antiretroviral drugs effectively suppressed viral replication. PMC11829058
Hu-NSG-Tg (IL-15) mice HIV infection model Oral 175 mg/kg Daily administration for 3 weeks To evaluate the antiviral effect of Darunavir in an HIV-infected mouse model, results showed that combination therapy effectively suppressed viral replication. PMC11829058

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03042390 - Completed - Spain ... More >> Hospital Costa del Sol Malaga, Marbella, Spain Hospital Clinic i Provincial Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital del Vall d'Hebron Barcelona, Spain Hospital Germans Trias i Pujol Barcelona, Spain Hospital de Guadalajara Guadalajara, Spain Hospital Infanta Leonor Madrid, Spain Hospital La Paz Madrid, Spain Hospital La Princesa Madrid, Spain Hospital Príncipe de Asturias Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Ramón y Cajal Madrid, Spain Hospital Virgen de la Victoria Malaga, Spain Hospital de Son Llatzer Palma de Mallorca, Spain Hospital de Valme Sevilla, Spain Complejo Hospitalario de Toledo Toledo, Spain Hospital Clínico de Valencia Valencia, Spain Hospital La Fe Valencia, Spain Complejo Hospitalaria Alvaron Cunqueiro Vigo, Spain Less <<
NCT01449929 Infection, Human Immunodeficie... More >>ncy Virus Less << Phase 3 Completed - -
NCT00854204 HIV-I Phase 1 Completed - -
NCT02486133 HIV-Infection Phase 3 Active, not recruiting December 2018 Germany ... More >> Klinikum rechts der Isar Munich, Germany, 81675 Less <<
NCT02984852 Healthy Phase 1 Completed - United States, Arizona ... More >> Tempe, Arizona, United States Less <<
NCT01449929 - Completed - -
NCT01013987 HIV-1 Adults Patients ... More >> AIDS Triple Class Failure Less << Phase 4 Unknown - Argentina ... More >> Fundación Huésped Recruiting Ciudad de Buenos Aires, Argentina, C1202ABB Contact: María C. Magneres, MD    54-11-4981-7777 ext 114    maria.magneres@huesped.org.ar    Contact: Patricia Luz Patterson, MD    54-11-4981-7777 ext 114    patricia.patterson@huesped.org.ar    Principal Investigator: Alejandro Krolewiecki, MD Less <<
NCT00543101 - Completed - -
NCT03472963 HIV Infections Phase 1 Recruiting January 15, 2019 United States, Georgia ... More >> Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Colleen Kelley, MD, MPH    404-712-1823    colleen.kelley@emory.edu Less <<
NCT03683524 HIV-1 Infection Phase 4 Not yet recruiting October 2020 -
NCT00677300 HIV Infections Phase 4 Completed - United States, Texas ... More >> Dallas VA Medical Center Dallas, Texas, United States, 75216 Parkland Health & Hospital System Dallas, Texas, United States, 75390 Less <<
NCT00115050 HIV Infections PHASE3 COMPLETED 2025-06-07 -
NCT00543101 HIV Infections Phase 4 Completed - United States, Arizona ... More >> Spectrum Medical Group Phoenix, Arizona, United States, 85012 United States, California AIDS Healthcare Foundation Los Angeles, California, United States, 02319 United States, Florida Orlando Immunology Center Orlando, Florida, United States United States, Massachusetts Community Research Initiative of New England Boston, Massachusetts, United States, 02215 United States, New York Albany Medical Center Albany, New York, United States, 12208 Less <<
NCT02285478 - Completed - Netherlands ... More >> Radboud University Medical Center Nijmegen, Netherlands Less <<
NCT00081588 HIV Infection PHASE2 COMPLETED 2025-12-08 Birmingham, Alabama, United St... More >>ates|Beverly Hills, California, United States|La Jolla, California, United States|Long Beach, California, United States|Los Angeles, California, United States|Oakland, California, United States|San Francisco, California, United States|Washington, District of Columbia, United States|Ft Lauderdale, Florida, United States|Miami, Florida, United States|Vero Beach, Florida, United States|Atlanta, Georgia, United States|Macon, Georgia, United States|Chicago, Illinois, United States|Boston, Massachusetts, United States|Springfield, Massachusetts, United States|Camden, New Jersey, United States|Albany, New York, United States|New York, New York, United States|Cincinnati, Ohio, United States|Hershey, Pennsylvania, United States|Philadelphia, Pennsylvania, United States|Dallas, Texas, United States|Galveston, Texas, United States|Seattle, Washington, United States|Milwaukee, Wisconsin, United States|Buenos Aires, Argentina|Darlinghurst, Australia|Melbourne, Australia|Perth, Australia|Vienna, Austria|Wien, Austria|Brussels, Belgium|Brussel, Belgium|Gent, Belgium|Campinas, Brazil|Curitiba, Brazil|Rio De Janeiro, Brazil|Sao Paulo, Brazil|Calgary, Alberta, Canada|Toronto, Ontario, Canada|Montreal, Quebec, Canada|Le Kremlin Bicetre, France|Montpellier, France|Nantes, France|Paris Cedex 10, France|Paris Cedex 12, France|Paris, France|Toulon, France|Villejuif Cedex, France|Berlin, Germany|Bonn, Germany|Düsseldorf, Germany|Essen, Germany|Freiburg, Germany|Hamburg, Germany|K?ln, Germany|Mannheim, Germany|Munich, Germany|Budapest, Hungary|Lisboa, Portugal|Porto, Portugal|Barakaldo Vizcaya S/N, Spain|Barcelona N/A, Spain|Madrid, Spain|Edinburgh, United Kingdom|London, United Kingdom|Manchester, United Kingdom Less <<
NCT01281813 HIV-1 Infections Phase 3 Active, not recruiting December 31, 2021 Brazil ... More >> Rio De Janeiro, Brazil Costa Rica San Jose, Costa Rica Guatemala Guatemala, Guatemala Malaysia Selangor, Malaysia Panama Panama, Panama South Africa Cape Town, South Africa Cyrildene Johannesburg Gauteng, South Africa Dundee, South Africa Durban, South Africa Johannesburg, South Africa Pretoria N/A, South Africa Soweto, South Africa Westdene Johannesburg Gauteng, South Africa Thailand Bangkok, Thailand Chiang Mai, Thailand Khon Kaen, Thailand Ukraine Vinnitsa, Ukraine Less <<
NCT02063360 Infection, Human Immunodeficie... More >>ncy Virus Less << Phase 1 Completed - -
NCT02489487 HIV-infection Phase 1 Completed - Thailand ... More >> Faculty of Medicine, Siriraj Hospital Bangkok, Wanglang Road, Thailand, 10700 Less <<
NCT00650832 HIV Phase 2 Completed - -
NCT00110877 HIV Infection Phase 3 Completed - -
NCT00071097 HIV Infections Phase 2 Completed - -
NCT02269917 Human Immunodeficiency Virus T... More >>ype 1 Less << Phase 3 Active, not recruiting March 31, 2020 -
NCT02269917 - Active, not recruiting - -
NCT03198884 - Active, not recruiting May 1, 2018 -
NCT00524368 - Completed - -
NCT03017872 HIV Infections Phase 4 Recruiting December 28, 2021 Argentina ... More >> Hospital G de Agudos JM Ramos Mejia Not yet recruiting Buenos Aires, Ciudad De Buenos Aires, Argentina, C1221ADC Contact: Marcelo Losso    5411 4127 0276    mlosso@hivramos.org.ar    Contact: Guillermo Viloria    5411 4931 5252    gviloria@hivramos.org.ar    Principal Investigator: Marcelo Losso, M.D.          Hospital Dr Diego Paroissien Not yet recruiting Isidro Casanova, Provincia De Buenos Aires, Argentina, 1765 Contact: Eduardo Warley    5411 1541 897 181    eduwarley@yahoo.com.ar    Contact: Maria Ines Vieni    5411 1136 877 377 ext 3340    inesvieni@gmail.com    Principal Investigator: Eduardo Warley, M.D.          CAICI Not yet recruiting Rosario, Provincia De Santa Fe, Argentina, S2000PBJ Contact: Sergio Lupo    54 9 341 515 7704    drsergiolupo@gmail.com    Contact: Luciana Peroni    54 341 424 8045    administracioncaici@gmail.com    Principal Investigator: Sergio Lupo, M.D.          Hospital Interzonal de Agudos San Juan de Dios Recruiting La Plata, Argentina, 1900 Contact: Martha Michaan    +54 9221 5765 131    mgmichaan@yahoo.com.ar    Principal Investigator: Martha Michaan, M.D.          Brazil Laboratório de Pesquisa Clinica Em Hiv/Aids - Instituto Nacional de Infectologia - Fiocruz Not yet recruiting Rio de Janeiro, Brazil, 21040-360 Contact: Beatriz Grinsztejn    +552122707064    beatriz.grinsztejn@gmail.com    Contact: Kelly Gama    +552138659614    kelly.gama@ini.fiocruz.br    Principal Investigator: Beatriz Grinsztejn, MD, PhD          Chile Hospital San Borja-Arriaran Not yet recruiting Santiago, Chile, 8360159 Contact: Marcelo Wolff    562- 555 6206    marcewolff@yahoo.com    Contact: Gladys Allendes    562-555-6206    gladys_allendes@yahoo.es    Principal Investigator: Marcelo Wolff, MD          Colombia ASISTENCIA Cientifica De Alta Complejidad S.A.S. Not yet recruiting Bogota, Colombia, 110010 Contact: Otto Sussmann    57-1- 5107600 ext 104    osussmann@gmail.com    Contact: Ana Julia Rojas    57-1-5107600 ext 128    coord.investigaciones@asistenciacientifica.com    Principal Investigator: Otto Sussmann, M.D.          Guinea Centre de traitementambulatoire de Donka ( Hopital de jour) Not yet recruiting Conakry, Guinea, BP:5845 Contact: Mohamed Cisse    +224 622 292 590    cissebibi1@gmail.com    Contact: Thierno Mamadou Tounkara    +224 622 318 171    tounkm@yahoo.fr    Principal Investigator: Mohamed Cisse, Prof.          India YRG Care Not yet recruiting Chennai, Tamil Nadu, India, 600113 Contact: Nagalingeswaran Kumarasamy    91 917 691 2007    kumarasamy@yrgcare.org    Contact: Faith Beulah    91 44 39106811    beulah@yrgcare.org    Principal Investigator: Nagalingeswaran Kumarasamy, MD          Malaysia University of Malaya Medical Centre Recruiting Kuala Lumpur, Malaysia, 59100 Contact: Raja Iskandar Shah Raja Azwa    603-79493834    iskandar.azwa@gmail.com    Contact: Margaret Tan    603-79492622    margarettan455@gmail.com    Principal Investigator: Raja Iskandar Shah Raja Azwa, MBChB, MRCP          Mali University of Sciences, Techniques and Technologies of Mali, University Clinical Research Center (UCRC) Not yet recruiting Bamako, Mali Contact: Sounkalo Doa    +223 72274971    sounkalod@icermali.org    Contact: Yacouba Cissoko    +22374567649 or +22397195994    ycissoko@hotmail.com    Principal Investigator: Sounkalo Doa, Prof.          Mexico Morales Vargas Centro de Investigacion SC Not yet recruiting León, Guanajuato, Mexico, 37000 Contact: Juan Luis Mosqueda Gomez    +52 (477) 1310037    luis_mosqueda@yahoo.com    Contact: Jorge Morales Vargas    +52 (477) 7160714    mnc.jorge@hotmail.com    Hospital Civil de Guadalajara Not yet recruiting Guadalajara, Jalisco, Mexico, 44280 Contact: Jaime Andrade-Villanueva       jandradev@msn.com    Contact: Angeles González-Hernández    5233 3614 7586    angelesghdez1@gmail.com    Principal Investigator: Jaime Andrade-Villanueva, M.D.          Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran Not yet recruiting Mexico City, Mexico, 14080 Contact: Juan Sierra Madero    52 5556559675    jsmadero@yahoo.com    Contact: Izchel Loyo       iz.inncm@outlook.com    Principal Investigator: Juan Sierra Madero, M.D.          Nigeria Institute of Human Virology, Nigeria (IHVN) Not yet recruiting Abuja, Nigeria, 9396 Contact: Ernest Ekong    +2348023107612    ernestekong@ihvnigeria.org    Contact: Nnakelu Eriobu    +2347039469273    neriobu@ihvnigeria.org    Principal Investigator: Ernest Ekong, MD          South Africa Desmond Tutu HIV Foundation Recruiting Cape Town, South Africa, 7925 Contact: Richard Kaplan       Richard.Kaplan@hiv-research.org.za    Contact: Christie Heiberg    27 21 406 3621    Christie.Heiberg@hiv-research.org.za    Principal Investigator: Richard Kaplan, M.D.          Clinical HIV Research Unit (CHRU), Wits Health Consotium (Pty) Ltd Recruiting Johannesburg, South Africa, 2041 Contact: Noluthando Mwelase       tmwelase@witshealth.co.za    Contact: Pauline Vunandala    27 11 276 8800    pvunandlala@witshealth.co.za    Principal Investigator: Noluthando Mwelase, MBCHB          Perinatal HIV Research Unit (PHRU), Chris Hani Baragwanath Hospital Recruiting Soweto, South Africa, 1864 Contact: Lerato Mohapi       mohapil@hivsa.com    Contact: Debra Peters    27 11 989 9700    petersd@phru.co.za    Principal Investigator: Lerato Mohapi, BSc, MBBCh          Thailand HIV-NAT (The HIV Netherlands Australia Thailand Research Collaboration), Thai Red Cross AIDS Research Centre Recruiting Bangkok, Thailand, 10330 Contact: Anchalee Avihingsanon    +662 652 3040 ext 107    anchaleea2009@gmail.com    Contact: Kanitta Pussadee    +662 652 3040 ext 202    kanitta.p@hivnat.org    Principal Investigator: Anchalee Avihingsanon, M.D.          Chiangrai Prachanukroh Hospital Not yet recruiting Chiang Rai, Thailand, 57000 Contact: Pacharee Kantipong    66818859195    pachareek@hotmail.com    Contact: Supawadee Pongprapass    66819616900    npudit@hotmail.com    Principal Investigator: Pacharee Kantipong, M.D.          Srinagarind Hospital, Khon Kaen University Recruiting Khon Kaen, Thailand, 40002 Contact: Ploenchan Chetchotisakd    6643363168    ploencha@kku.ac.th    Contact: Anchalee Tiyabut    6643363169    atiyabut@yahoo.com    Principal Investigator: Ploenchan Chetchotisakd, M.D.          Bamrasnaradura Infectious Diseases Institute Recruiting Nonthaburi, Thailand, 11000 Contact: Weerawat Manosuthi       drweerawat@hotmail.com    Contact: Supeda Thongyen    6625903631    supeda_t@yahoo.com    Principal Investigator: Weerawat Manosuthi, M.D.          Zimbabwe University of Zimbabwe Clinical Research Centre Recruiting Harare, Zimbabwe, +263 Contact: James G Hakim    263 772225489    Jhakim@mweb.co.zw    Contact: Shepherd Mudzingwa    263 4 701717    smudzingwa@yahoo.com    Principal Investigator: James G Hakim, M.D. Less <<
NCT00855335 - Completed - -
NCT00849160 HIV-1 Infection ... More >> HIV Infections Less << Phase 3 Completed - France ... More >> Centre Hospitalier Universitaire de Bicêtre - Service de Médecine Interne et Maladies Tropicales Le Kremlin Bicêtre, France, 94275 Groupe Hospitalier Pitié-Salpêtrière - Service de Médecine Interne Paris, France, 75013 Groupe Hospitalier Pitié-Salpêtrière - Service des Maladies Infectieuses et Tropicales Paris, France, 75013 Hôpital Necker Enfants Malades - Service des Maladies Infectieuses et Tropicales Paris, France, 75015 Hôpital Tenon - Service des Maladies Infectieuses et Tropicales Paris, France, 75020 Less <<
NCT00757783 HIV Phase 4 Completed - United States, California ... More >> Los Angeles, California, United States United States, Connecticut Glastonbury, Connecticut, United States United States, District of Columbia Washington, District of Columbia, United States United States, Florida Fort Lauderdale, Florida, United States Miami, Florida, United States Orlando, Florida, United States United States, Indiana Indianapolis, Indiana, United States United States, Massachusetts Boston, Massachusetts, United States United States, Minnesota Minneapolis, Minnesota, United States United States, Missouri Saint Louis, Missouri, United States United States, New Jersey Hillsborough, New Jersey, United States United States, New York New York, New York, United States United States, Ohio Cincinnati, Ohio, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Texas Dallas, Texas, United States Less <<
NCT00524368 Human Immunodeficiency Virus -... More >> Type 1 Less << Phase 3 Completed - -
NCT01615601 - Completed - Canada ... More >> Vancouver, Canada Less <<
NCT00757783 - Completed - -
NCT00513513 HIV Infections Phase 2 Terminated(Poor recruitment.) - -
NCT00855335 HIV HIV Infec... More >>tions Pregnancy Less << Phase 3 Completed - United States, Florida ... More >> Daytona Beach, Florida, United States Jacksonville, Florida, United States Miami, Florida, United States Pensacola, Florida, United States Port Saint Lucie, Florida, United States West Palm Beach, Florida, United States United States, Georgia Savannah, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Springfield, Massachusetts, United States United States, Michigan Dearborn, Michigan, United States United States, New York Bronx, New York, United States Syracuse, New York, United States United States, North Carolina Chapel Hill, North Carolina, United States Greensboro, North Carolina, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Texas Bellaire, Texas, United States Puerto Rico San Juan Pr, Puerto Rico Less <<
NCT01680536 HIV Phase 4 Completed - United Kingdom ... More >> St Stephen's AIDS Trust London, United Kingdom, SW10 9TH Less <<
NCT02475135 Healthy Phase 1 Completed - Belgium ... More >> Antwerp, Belgium Less <<
NCT00994344 HIV Infections Phase 4 Completed - Spain ... More >> Germans Trias i Pujol Hospital Badalona, Barcelona, Spain, 08916 Hospital Universitario de Canarias Santa Cruz de Tenerife, Canarias, Spain, 38320 Less <<
NCT00381303 - Completed - -
NCT02431247 Immunodeficiency Virus Type 1,... More >> Human Less << Phase 3 Active, not recruiting April 5, 2020 -
NCT00531557 HIV Infections Phase 4 Completed - United Kingdom ... More >> St Stephens Centre, Chelsea & Westminster Hospital London, United Kingdom Less <<
NCT00534352 HIV-1 Infection Phase 2 Completed - -
NCT00381303 HIV Infectiou... More >>s Less << Phase 3 Completed - -
NCT02431247 - Active, not recruiting - -
NCT00534352 - Completed - -
NCT00460746 HIV Phase 3 Completed - United States, California ... More >> Los Angeles, California, United States Less <<
NCT01348763 HIV Phase 1 Completed - United Kingdom ... More >> Imperial College Healthcare NHS Trust London, United Kingdom, W2 1NY Less <<
NCT00421551 HIV Infections Phase 3 Completed - France ... More >> Service des maladies infectieuses et tropicales Hopital Pitie salpetriere Paris, France, 75013 Less <<
NCT00460746 - Completed - -
NCT00830804 HIV-1 Infections Phase 2 Completed - United States, Alabama ... More >> AlabamaTherapeutics CRS Birmingham, Alabama, United States, 35294 United States, California Stanford CRS Palo Alto, California, United States, 94304 Ucsd, Avrc Crs San Diego, California, United States, 92103 Ucsf Aids Crs San Francisco, California, United States, 94110 United States, Colorado University of Colorado Hospital CRS Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown University CRS Washington, District of Columbia, United States, 20007 United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 United States, Massachusetts Beth Israel Deaconess Med Center Boston, Massachusetts, United States, 02115 Brigham and Women's Hosp. ACTG CRS Boston, Massachusetts, United States, 02115 United States, Missouri Washington U CRS Saint Louis, Missouri, United States, 63110 United States, New York AIDS Community Health Ctr. ACTG CRS Rochester, New York, United States, 14604 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 Duke Univ. Med. Ctr. Adult CRS Durham, North Carolina, United States, 27710 United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 45267-0405 Case CRS Cleveland, Ohio, United States, 44106 MetroHealth CRS Cleveland, Ohio, United States, 44109 The Ohio State Univ. AIDS CRS Columbus, Ohio, United States, 43210 United States, Pennsylvania Hosp. of the Univ. of Pennsylvania CRS Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh CTU Pittsburgh, Pennsylvania, United States, 15213 United States, Rhode Island The Miriam Hospital Providence, Rhode Island, United States, 02906 United States, Tennessee Vanderbilt Therapeutics CRS Nashville, Tennessee, United States, 37203 United States, Texas Houston AIDS Research Team Houston, Texas, United States, 77030 Less <<
NCT00919854 Human Immunodeficiency Virus 1 Phase 2 Completed - Argentina ... More >> Buenos Aires, Argentina Brazil Rio De Janeiro, Brazil Sao Paulo, Brazil India Chennai, India Kenya Kilifi, Kenya South Africa Durban, South Africa Johannesburg Gauteng, South Africa Johannesburg, South Africa Less <<
NCT00830804 - Completed - -
NCT00919854 - Completed - -
NCT01448707 Human Immunodeficiency Virus (... More >>HIV) Infections Acquired Immunodeficiency Syndrome (AIDS) Virus Less << Phase 3 Completed - -
NCT00744887 HIV|AIDS PHASE1 COMPLETED 2025-12-08 -
NCT01448707 - Completed - -
NCT02159352 Hepatitis C Phase 1 Completed - United States, Texas ... More >> Healthcare Discoveries, Llc D/B/A Icon Development Solutions San Antonio, Texas, United States, 78209 Less <<
NCT01519336 Healthy Volunteer Phase 1 Completed - United States, Kansas ... More >> Lenexa, Kansas, United States, 66219 Less <<
NCT01066962 HIV Infections Phase 3 Completed - -
NCT01702090 HIV-1 Phase 4 Completed - Taiwan ... More >> Taipei, Taiwan Less <<
NCT02770508 HIV-1 Infection Phase 4 Completed - Argentina ... More >> Consultorio Infectológico Dr. Pryluka Caba, Buenos Aires, Argentina, 1121 Hospital Cosme Argerich Caba, Buenos Aires, Argentina, 1155ADP Hospital Italiano Caba, Buenos Aires, Argentina, 1199ABB Fundacion huesped Caba, Buenos Aires, Argentina, C1202ABB Centro de Estudios Infectologicos SA (CTD Stamboulian) Caba, Buenos Aires, Argentina, C1425AWK Less <<
NCT00765271 HIV Phase 1 Completed - United Kingdom ... More >> Chelsea and Westminster Hospital London, United Kingdom, SW10 9TH Less <<
NCT00964327 HIV Infections PHASE2 COMPLETED 2025-10-03 -
NCT00765154 HIV Phase 4 Terminated(Difficulties in rec... More >>ruitment due to a change in the nature of practice.) Less << - United Kingdom ... More >> Chelsea and Westminster Hospital London, United Kingdom, SW10 9TH Less <<
NCT01294761 HIV Infections Not Applicable Completed - Japan ... More >> National Center for Global Health and Medicine Shinjuku, Tokyo, Japan, 1628655 Less <<
NCT00355524 HIV-1 HIV Inf... More >>ections Less << Phase 2 Completed - United States, California ... More >> Los Angeles, California, United States United States, District of Columbia Washington, District of Columbia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Boston, Massachusetts, United States Worcester, Massachusetts, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Tennessee Memphis, Tennessee, United States Argentina Buenos Aires, Argentina Brazil Belo Horizonte, Brazil Nova Iguacu, Brazil Ribeirao Preto, Brazil Rio De Janeiro, Brazil Canada, Ontario Toronto, Ontario, Canada Canada, Quebec Montreal, Quebec, Canada France Paris, France Romania Bucuresti, Romania Constanta, Romania South Africa Cape Town Cape, South Africa Durban, South Africa Johannesburg Gauteng, South Africa Spain Esplugues De Llobregat, Spain Madrid, Spain Less <<
NCT00611039 HIV Infections Phase 4 Completed - Spain ... More >> Germans Trias i Pujol Hospital Badalona, Barcelona, Spain, 08916 Less <<
NCT01308658 Healthy Phase 1 Completed - Germany ... More >> Berlin, Germany Less <<
NCT02159352 - Completed - -
NCT00993148 - Completed - -
NCT02155101 HIV/AIDS Phase 3 Completed - Cameroon ... More >> Yaounde Central Hospital Yaounde, Centre, Cameroon, 5777 Less <<
NCT01391013 - Completed - -
NCT00855413 Acute HIV Infection ... More >> HIV Infections Less << Phase 4 Terminated(Study halted by spo... More >>nsor due to slow enrollment.) Less << - United States, North Carolina ... More >> The University of North Carolina - Chapel Hill Chapel Hill, North Carolina, United States, 27599 Duke University Durham, North Carolina, United States, 27707 Less <<
NCT01391013 Human Immunodeficiency Virus 1 Phase 2 Completed - -
NCT00458302 HIV Infections ... More >> AIDS Virus Human Immunodeficiency Virus Acquired Immunodeficiency Syndrome Virus Less << Phase 3 Completed - Austria ... More >> Wien, Austria Belgium Antwerpen, Belgium Bruxelles, Belgium Denmark Aarhus, Denmark Copenhagen, Denmark Hvidovre, Denmark Odense, Denmark Germany Berlin, Germany Frankfurt, Germany Hamburg, Germany Hannover, Germany Kÿln N/A, Germany Hungary Budapest, Hungary Israel Jerusalem, Israel Tel Aviv, Israel Tel Hashomer, Israel Portugal Lisbon, Portugal Porto, Portugal Russian Federation Moscow, Russian Federation Saint-Petersburg, Russian Federation Spain Barcelona N/A, Spain Barcelona, Spain Donostia Guipuzcoa, Spain Granada, Spain Madrid, Spain Valladolid N/A, Spain Switzerland St Gallen, Switzerland United Kingdom London, United Kingdom Less <<
NCT00458302 - Completed - -
NCT02199613 HIV Infection Phase 4 Completed - Canada, British Columbia ... More >> St. Paul's Hospital Immunodeficiency Clinic Vancouver, British Columbia, Canada, V6Z 1Y6 Less <<
NCT00993148 HIV-1 Infection ... More >> HIV Infections Less << Phase 2 Completed - United States, California ... More >> Quest Clinical Research San Francisco, California, United States United States, Florida University of Miami Miami, Florida, United States United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 CORECenter Chicago, Illinois, United States, 60612 United States, Nebraska University of Nebraska Omaha, Nebraska, United States Less <<
NCT01726348 - Withdrawn(The company decided ... More >>to cancel this study in conformity with PH FDA Circular 2013-004) Less << December 2014 -
NCT01367210 HIV Infection Phase 4 Terminated(Because a higher ra... More >>te of virological failures in study versus control arm.) Less << - Italy ... More >> Catholic University of Sacred Heart Rome, Italy, 00168 Less <<
NCT00630734 HIV Infections ... More >> Hyperlipidemia Less << Phase 4 Completed - United States, Colorado ... More >> University of Colorado Denver Aurora, Colorado, United States, 80045 Less <<
NCT00855413 - Terminated(Study halted by spo... More >>nsor due to slow enrollment.) Less << - -
NCT03602690 HIV/AIDS Phase 2 Recruiting October 3, 2020 Cambodia ... More >> NCHADS Recruiting Phnom Penh, Cambodia Contact: Sun Ly Penh, MD Less <<
NCT00630734 - Completed - -
NCT01258374 - Completed - Spain ... More >> Hospital Clinic Barcelona, Spain, 08036 Less <<
NCT02159599 HIV Infection Phase 4 Completed - Spain ... More >> Hospital Universitario de Bellvitge Hospitalet de Llobregat, Barcelona, Spain Hospital General Universitario de Alicante Alicante, Spain Hospital Universitario Germans Trias i Pujol Badalona, Spain Hospital Clinic Barcelona, Spain Hospital de La Santa Creu I Sant Pau Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital Universitario Vall D'Hebron Barcelona, Spain Hospital Universitario Reina Sofía Córdoba, Spain Hospital Universitario Virgen de las Nieves Granada, Spain Complejo Hospitalario de Huelva Huelva, Spain Hospital 12 de Octubre Madrid, Spain Hospital Universitario Clínico San Carlos Madrid, Spain Hospital Universitario Fundación Alcorcón Madrid, Spain Hospital Universitario Gregorio Marañón Madrid, Spain Hospital universitario Infanta Leonor Madrid, Spain Hospital Universitario La Paz Madrid, Spain Hospital Universitario Príncipe de Asturias Madrid, Spain Hospital de Mataró Mataró, Spain Hospital Universitario Virgen de la Victoria Málaga, Spain Hospital Universitario Donostia San Sebastián, Spain Hospital Universitario Miguel Servet Zaragoza, Spain Less <<
NCT01073761 HIV HIV Infec... More >>tions Less << Phase 1 Completed - United Kingdom ... More >> St Stephen's Centre London, United Kingdom, SW10 9TH Less <<
NCT01810887 Healthy Phase 4 Completed - Japan ... More >> Tsukuba, Japan Less <<
NCT01046890 HIV Infections Phase 4 Completed - Spain ... More >> Lluita contra la Sida Foundation, HIV Unit, Irsi Caixa Foundation Badalona, Spain, 08916 Less <<
NCT02404233 HIV Positive Phase 4 Unknown December 2016 United States, Texas ... More >> Therapeutic Concepts, P.A. Not yet recruiting Houston, Texas, United States, 77004 Contact: Joseph C. Gathe, M.D.    713-526-9821    drgathe@josephgathe.com    Contact: Valerie H. Davis, B.S.    713-526-9821    vdavis@josephgathe.com    Principal Investigator: Joseph C. Gathe, M.D.          Therapeutic Concepts, PA Houston, Texas, United States, 77004 Less <<
NCT02337322 Acquired Immune Deficiency Syn... More >>drome Virus Less << Phase 4 Active, not recruiting December 2019 Spain ... More >> Hospital Clinic of Barcelona Barcelona, BCN, Spain, 08013 Less <<
NCT02187107 HIV Phase 2 Completed - Australia ... More >> Darlinghurst, Australia Austria Wien, Austria Belgium Gent, Belgium Denmark Copenhagen, Denmark Germany Berlin, Germany Hamburg, Germany Hannover, Germany Munich, Germany Poland Szczecin, Poland Russian Federation Sint Petersburg, Russian Federation United Kingdom London, United Kingdom Less <<
NCT02578550 Healthy Phase 1 Completed - Netherlands ... More >> Groningen, Netherlands Less <<
NCT01374802 HIV Infections Phase 1 Completed - Germany ... More >> 1220.49.1 Boehringer Ingelheim Investigational Site Berlin, Germany Less <<
NCT01374802 - Completed - -
NCT02589158 HIV Phase 1 Completed - United Kingdom ... More >> St Stephen's Centre, Chelsea and Westminster Hospital NHS Foundation Trust London, United Kingdom, SW10 9NH Less <<
NCT01258439 HIV Cardiovas... More >>cular Disease Less << Phase 4 Completed - Australia, New South Wales ... More >> Holdsworth House Medical Practice Sydney, New South Wales, Australia, 2010 St Vincent Hospital, Clinical Research Program Sydney, New South Wales, Australia, 2010 Less <<
NCT01741831 - Completed - Korea, Republic of ... More >> Dae-Gu, Korea, Republic of Less <<
NCT02818348 HIV-1 Infection Phase 1 Completed - Spain ... More >> Fundació Lluita contra la SIDA Badalona, Barcelona, Spain, 08916 Less <<
NCT01541085 - Completed - -
NCT01619527 Healthy Participants Phase 1 Completed - Belgium ... More >> Merksem, Belgium Less <<
NCT03094507 HIV Phase 1 Completed - United Kingdom ... More >> St Stephen's Centre London, United Kingdom, SW10 9NH Less <<
NCT02499978 HIV/AIDS Phase 2 Phase 3 Withdrawn - United States, California ... More >> Stanford Univerity Stanford, California, United States, 94305 United States, Colorado University of Colorado Aurora, Colorado, United States, 80045 Less <<
NCT01375881 - Completed - -
NCT01423812 HIV Phase 4 Completed - United States, Illinois ... More >> Ruth M. Rothstein CORE Center Chicago, Illinois, United States, 60612 Less <<
NCT01346982 HIV Phase 4 Completed - Spain ... More >> Lluita contra la Sida Foundation, HIV Unit Badalona, Barcelona, Spain, 08916 Less <<
NCT01423812 - Completed - -
NCT01928407 HIV-1 Infection ... More >> Immunosuppression-related Infectious Disease Less << Phase 4 Completed - France ... More >> Hopital Zobda Quitman Fort De France, Martinique, France, 97261 Centre Hospitalier D'Argenteuil Argenteuil, France, 95107 Hopital Saint-Jacques Besancon, France, 25000 Hopital Avicenne Bobigny, France, 93000 Hopital Jean Verdier Bondy, France, 93143 Hopital Saint-Andre Bordeaux, France, 33075 Chu Cote de Nacre Caen, France, 14033 Hopital Louis Mourier Colombes, France, 92700 Hopital Le Bocage Dijon, France, 21034 Hopital Raymond Poincare Garches, France, 92380 C.H.D de Vendee La Roche Sur Yon, France, 85925 Hopital Dupuytren Limoges, France, 87000 Hopital Sainte-Marguerite Marseille, France, 13274 Centre Hospitalier de Melun Melun, France, 77011 Hopital L'Archet Nice, France, 06202 Hopital Lariboisiere Paris, France, 75010 Hopital Saint Antoine Paris, France, 75012 Hopital Pitie-Salpetriere Paris, France, 75013 Hopital Necker Paris, France, 75015 Hopital Bichat Paris, France, 75018 Hopital Tenon Paris, France, 75020 Hopital Pitie-Salpetriere Paris, France, 75651 Hopital Cochin Paris, France, 75674 Hopital Europeen Georges Pompidou Paris, France, 75908 Hopital Saint-Jean Roussillon Perpignan, France, 66046 Hopital Rene Dubos Pontoise, France, 95303 C.H.R.A Pringy, France, 74374 Hopital Civil Strasbourg, France, 67000 Hopital Gustave Dron Tourcoing, France, 59208 Hopital Bretonneau Tours, France, 37044 Less <<
NCT01869634 Human Immunodeficiency Virus I... More >>nfection Less << Phase 4 Completed - United States, California ... More >> University of California Davis Sacramento, California, United States, 95617 Less <<
NCT00885495 HIV Infections Phase 1 Phase 2 Unknown August 2009 United States, Ohio ... More >> University of Cincinnati AIDS Clinical Trials Unit Cincinnati, Ohio, United States, 45267 Less <<
NCT01047995 HIV Infections Phase 1 Completed - United Kingdom ... More >> St Stephen's Centre, Chelsea and Westminster Hospital NHS Foundation Trust London, United Kingdom, SW10 9NH St Stephens Centre, Chelsea & Westminster Hospital London, United Kingdom, SW10 9NH Less <<
NCT03589027 HIV-1-infection ... More >> Contraception Less << Phase 2 Recruiting June 2020 Uganda ... More >> Infectious Diseases Institue Recruiting Kampala, Uganda, 256 Contact: Stephen Research Manager    0392878652    sokoboi@idi.co.ug    Principal Investigator: Mohammed Lamorde, PhD          Sub-Investigator: Kimberley Scarsi, PharmD,MSc          Sub-Investigator: Catherine Chappell, MD, MSc          Sub-Investigator: Saye Khoo, PhD          Sub-Investigator: Pauline Byakika, PhD          Sub-Investigator: Kristin Darin, PharmD          Sub-Investigator: Shadia Nakalema, MBChB, DTM&H          Sub-Investigator: Stephen Walimbwa, MD          Sub-Investigator: Julian Kaboggoza, BPharm Less <<
NCT01695954 Hyperlipidemia ... More >> HIV Less << Phase 1 Unknown October 2012 United States, New York ... More >> Bellevue/NYU AIDS Clinical Trials Unit New York, New York, United States, 10016 Less <<
NCT02671383 HIV Infections Phase 3 Completed - South Africa ... More >> Charlotte Maxeke Johannesburg Academic Hospital Johannesburg, Gauteng, South Africa, 2196 Less <<
NCT01606722 - Completed - Spain ... More >> Hospital Universitarios Virgen del Rocio Seville, Spain, 41013 Less <<
NCT02384967 HIV INFECTION PHASE2 COMPLETED 2025-10-16 H?pital Saint Louis, Paris, 75... More >>010, France Less <<
NCT03123848 Healthy Phase 4 Completed - Japan ... More >> Souseikai Hakata Clinic Fukuoka, Japan, 8120025 Less <<
NCT03123848 - Completed - -
NCT02503462 AIDS-related Dementia Complex Phase 4 Terminated(No additional patie... More >>nts fulfilling the inclusion criteria) Less << - Switzerland ... More >> Division of Infectious Diseases, University Hospital Basel Basel, BS, Switzerland, 4031 Less <<
NCT03101644 Human Immunodeficiency Virus I... More >> Infection Less << PHASE4 COMPLETED 2019-06-12 Cliniques universitaires Saint... More >>-Luc, Brussels, 1200, Belgium Less <<
NCT03589040 HIV Contracep... More >>tion Less << Phase 2 Not yet recruiting June 2020 Uganda ... More >> Infectious Diseases Institue Not yet recruiting Kampala, Uganda, 256 Contact: Stephen Research Manager    0392878652    sokoboi@idi.co.ug    Principal Investigator: Mohammed Lamorde, PhD          Sub-Investigator: Kimberley Scarsi, PharmD,MSc          Sub-Investigator: Catherine Chappell, MD, MSc          Sub-Investigator: Saye Khoo, PhD          Sub-Investigator: Pauline Byakika, PhD          Sub-Investigator: Kristin Darin, PharmD          Sub-Investigator: Shadia Nakalema, MBChB, DTM&H          Sub-Investigator: Stephen Walimbwa, MD          Sub-Investigator: Julian Kaboggoza, BPharm Less <<
NCT01736761 HIV Phase 4 Completed - United Kingdom ... More >> St Stephen's AIDS Trust London, United Kingdom, SW10 9TH Less <<
NCT00855088 HIV/AIDS HIV ... More >>Infections Less << Phase 1 Completed - United States, North Carolina ... More >> UNC Hospitals CTRC Chapel Hill, North Carolina, United States, 27514 Less <<
NCT02556268 HIV-DDI Phase 1 Completed - United States, Florida ... More >> Orlando, Florida, United States, 32803 United States, Massachusetts Boston, Massachusetts, United States, 02118 Less <<
NCT02469246 HIV-1 Infection Phase 3 Active, not recruiting March 2019 -
NCT00708162 HIV Infection Phase 3 Completed - -
NCT02121795 HIV-1 Infection Phase 3 Active, not recruiting January 2019 -
NCT00708162 - Completed - -
NCT01939197 Hepatitis C Virus Infection ... More >> Human Immunodeficiency Virus Infection Chronic Hepatitis C Compensated Cirrhosis and Non-cirrhotics Less << Phase 2 Phase 3 Completed - -
NCT02469246 - Active, not recruiting - -
NCT00850395 - Completed - -
NCT02336074 HIV Phase 2 Active, not recruiting November 2022 United Kingdom ... More >> Brighton and Sussex University Hospitals NHS Trust Brighton, United Kingdom Central and North West London NHS Foundation Trust London, United Kingdom Chelsea and Westminster NHS Foundation Trust London, United Kingdom Guy's and St Thomas' NHS Foundation Trust London, United Kingdom Imperial College Healthcare NHS Trust London, United Kingdom Royal Free Hospital NHS Foundation Trust London, United Kingdom Less <<
NCT01939197 - Completed - -
NCT01254656 HIV-1 Phase 2 Terminated(See termination rea... More >>son in detailed description.) Less << - Australia, New South Wales ... More >> Pfizer Investigational Site Darlinghurst, New South Wales, Australia, 2010 Australia, Victoria Pfizer Investigational Site Melbourne, Victoria, Australia, 3004 Brazil Pfizer Investigational Site Nova Iguacu, RJ, Brazil, 26030-381 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 1K2 Canada, Quebec Pfizer Investigational Site Montreal, Quebec, Canada, H2L 4P9 Pfizer Investigational Site Montreal, Quebec, Canada, H2L 5B1 Italy Pfizer Investigational Site Milano, Italy, 20127 Pfizer Investigational Site Torino, Italy, 10149 Mexico Pfizer Investigational Site Mexico, Distrito Federal, Mexico, 14050 Poland Pfizer Investigational Site Bydgoszcz, Poland, 85-030 Pfizer Investigational Site Warszawa, Poland, 01-201 South Africa Pfizer Investigational Site Johannesburg, Gauteng, South Africa, 2193 Pfizer Investigational Site Pretoria, Gauteng, South Africa, 0083 Pfizer Investigational Site Soweto, Gauteng, South Africa, 2013 Pfizer Investigational Site Durban, Kwazulu-Natal, South Africa, 4001 Pfizer Investigational Site Cape Town, Western Cape, South Africa, 7925 Pfizer Investigational Site Pretoria, South Africa, 0083 Switzerland Pfizer Investigational Site Lugano, Switzerland, 6903 Pfizer Investigational Site St. Gallen, Switzerland, 9007 Pfizer Investigational Site Zuerich, Switzerland, 8091 United Kingdom Pfizer Investigational Site Brighton, East Sussex, United Kingdom, BN2 1ES Pfizer Investigational Site London, United Kingdom, NW3 2QG Pfizer Investigational Site London, United Kingdom, SW10 9NH Less <<
NCT00850395 - Completed - -
NCT01231685 HIV Hepatitis... More >> C Liver Fibrosis Less << Phase 2 Completed - Canada, British Columbia ... More >> Providence Health Care- St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Canada, Ontario University Health Network - Toronto General Hospital Division Toronto, Ontario, Canada, M5G2N2 Canada, Quebec Montreal Chest Institute Montreal, Quebec, Canada Less <<
NCT02121795 - Active, not recruiting - -
NCT02577042 Aging-related Inflammation in ... More >>HIV-infected Patients Less << Phase 4 Completed - Spain ... More >> Germans Trias i Pujol Hospital Badalona, Barcelona, Spain, 08916 Less <<
NCT02616783 HIV-1 Infection Phase 3 Completed - Belgium ... More >> CHU Saint-Pierre University Hospital Brussels, Belgium University Hospital Gent Ghent, Belgium France CHU - Groupe Saint-Andre Bordeaux, France CHU de Dijon Dijon, France Hopital Europeen Marseille Marseille, France C.H.U. de Nantes Nantes, France C.H.U. de NICE Nice, France Hopital Saint Louis Paris cedex 10, France Hopital Saint Antoine Paris cedex 12, France CHU Hotel Dieu Paris, France Hopital Necker les Enfants Malades Paris, France Hopital Haut-Leveque Pessac, Cedex, France Service des Maladies Infectieuses et du Voyageur Tourcoing, France Italy Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Italy Busto Arsizio Hospital Busto Arsizio, Italy IRCCS A.O.U. San Martino Genova, Italy Azienda Ospedaliera Luigi Sacco Milano, Italy Azienda Ospedaliero Universitaria Policlinico di Modena Modena, Italy U.O. Malattie Infettive Pescara, Italy Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S. Roma, Italy Azienda Ospedaliero Universitaria di Sassari Sassari, Italy Dipartimento di Malattie Infettive e Tropicali Torino, Italy Spain Hospital Clinic de Barcelona Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Universitari Germans Trias i Pujol Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital 12 de Octubre Madrid, Spain Hospital General Universitario Gregorio Maranon Madrid, Spain Hospital Universitario La Paz Madrid, Spain Ramon Y Cajal University Hospital Madrid, Spain Hospital Costa Del Sol Marbella, Spain Hospital General Universitario de Valencia Valencia, Spain United Kingdom Royal Victoria Hospital Belfast, United Kingdom Mortimer Market Centre London, United Kingdom Newcastle Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom Less <<
NCT01252940 HIV-1 Infection Phase 3 Completed - -
NCT01252940 - Completed - -
NCT01254656 - Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT02491242 - Completed - Spain ... More >> Ramon y Cajal Hospital Madrid, Spain, 28034 Less <<
NCT02302547 HIV Phase 3 Completed - France ... More >> Unité des Maladies Infectieuses, CHU de CAEN Caen, France, 14033 Service des Maladies Infectieuses, CHR Orléans La Source, ORLEANS CEDEX 2 CHR d'ORLEANS, France, 45067 Service d'Immunologie Clinique centre de Vaccination anti- VIH ANRS Hopital Henri- Mondor Creteil, France, 94010 Service de Médecine Interne et Maladies Infectieuses, Groupe Hospitalier La Rochelle, Cedex 01 La Rochelle, France, 17019 Service de Pneumologie, centre Hospitalier Fontenoy, CH de CHARTRES Le Coudray, France, 28630 CHU de NANCY Nancy, France, 54035 Service des maladies Infectieuses et tropicales, CH GEORGES RENON Niort, France, 79021 Service des Maladies Infectieuses et tropicales, APHP SAINT LOUIS Paris, France, 75475 Hospital Tenon Paris, France, 75970 Centre de diagnostic et thérapeutique, Hopital Hotel Dieu Paris, France, 94010 Consultation Maladies Infectieuses, Chu de Poitiers, Cedex Poitiers, France, 86021 Maladies Infectieuses, CHU de ROUEN Rouen, France, 76031 Service de Médecine Interne, CH de SAINTONGE- BP 326 Saintes, France, 17108 Médecine Interne, Hôpital FOCH Suresnes, France, 92151 Service Universitaire des Maladies Infectieuses et du Voyageur, CH DRON Tourcoing, France, 59200 Service de Medecine Interne et Maladies Infectieuses, CHRU BRETONNEAU, TOURS CEDEX9 Tours, France, 37044 Less <<
NCT02605954 HIV-1 Infection Phase 3 Completed - -
NCT01497899 Acquired Immunodeficiency Synd... More >>rome HIV Infections Less << Phase 2 Completed - -
NCT02605954 - Completed - -
NCT01637233 - Completed - Argentina ... More >> Hospital Ramos Mejía Buenos Aires, Argentina, C1221ADC Fundación IDEAA Buenos Aires, Argentina, C1405CKC CAICI Rosario, Argentina Thailand Chulalongkorn University Hospital Bangkok, Thailand, 10330 United Kingdom Brighton & Sussex University NHS Trust Brighton, Sussex, United Kingdom, BN21ES, Imperial Healthcare, St. Mary's Hospital London, United Kingdom, W2 Less <<
NCT01475838 - Completed - -
NCT00884793 HIV Infections Not Applicable Completed - United States, California ... More >> San Francisco General Hospital San Francisco, California, United States, 94110 San Francisco VA Medical Center (SFVAMC) San Francisco, California, United States, 94121 Less <<
NCT01497899 - Completed - -
NCT03631732 HIV-1 Infection Phase 3 Recruiting August 2020 -
NCT02157311 HIV-1 Infection Phase 3 Completed - France ... More >> Hôpital Meynard Fort-de-france, Martinique, France, 97261 Hôpital Avicenne Bobigny, France, 93000 CHU Côte de Nacre Caen, France, 14033 Centre Hospitalier Sud Francilien Corbeil Essonnes, France, 91100 Hôpital Le Bocage Dijon, France, 21079 Hôpital Raymond Poincaré Garches, France, 92380 Hôpital Bicêtre Kremlin Bicetre, France, 94275 Hôpital Gui de Chauliac Montpellier, France, 34295 Hôpital Saint-Antoine Paris, France, 75012 Hôpital Pitié-Salpêtrière Paris, France, 75013 Hôpital Européen Georges Pompidou Paris, France, 75015 Hôpital Necker Paris, France, 75015 Hôpital Bichat Paris, France, 75018 Hôpital Tenon Paris, France, 75020 Hôpital Foch Suresnes, France, 92151 Hôpital Purpan Toulouse, France, 31059 Hôpital Bretonneau Tours, France, 37044 Less <<
NCT01814722 - Terminated(The trial was termi... More >>nated early due to slow recruitment.) Less << - -
NCT01475838 Acquired Immunodeficiency Synd... More >>rome HIV Infections Less << Phase 3 Completed - -
NCT00884793 - Completed - -
NCT01814722 - Terminated(The trial was termi... More >>nated early due to slow recruitment.) Less << - -
NCT00966329 HIV HIV Infec... More >>tions Less << Phase 4 Completed - Spain ... More >> Germans Trias i Pujol Hospital Badalona, Barcelona, Spain, 08916 Lluita contra la Sida Foundation, HIV Unit, Irsi Caixa Foundation Badalona, Barcelona, Spain, 08916 Lluita contra la Sida Foundation, HIV Unit Badalona, Barcelona, Spain, 08916 Less <<
NCT02285114 HIV-1 Phase 2 Phase 3 Recruiting December 2024 United States, California ... More >> UCLA Recruiting Los Angeles, California, United States, 90095 United States, Colorado Children's Hospital Colorado Recruiting Aurora, Colorado, United States United States, Pennsylvania St. Christopher's Hospital, for Children Recruiting Philadelphia, Pennsylvania, United States, 19134 United States, Tennessee St. Judes Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 United States, Washington Seattle Children's Hospital Recruiting Seattle, Washington, United States Panama Hospital del Nino Recruiting Panama City, Panama South Africa Be Part Yoluntu Centre Recruiting Cape Town, South Africa University of Stellenbosch Recruiting Cape Town, South Africa Rahima Moosa Mother and Child Hopsital Recruiting Johannesburg, South Africa Less <<
NCT01923311 Acquired Immune Deficiency Syn... More >>drome (AIDS) HIV Infections Less << Phase 2 Phase 3 Terminated - United States, Colorado ... More >> University of Colorado Denver Aurora, Colorado, United States, 80045 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Italy Universita degli Studi di Pavia - Fondazione IRCCS Policlinico San Matteo Pavia, Italy, 27100 South Africa Be Part Yoluntu Centre Cape Town, South Africa, 7646 Rahima Moosa Mother and Child Hopsital Johannesburg, South Africa, 2112 Spain Hospital Universitario De Getafe Getafe, Madrid, Spain, 28095 Hospital 12 de Octubre Madrid, Spain, 28041 Thailand Thai Red Cross AIDS Research Centre (HIV-NAT) Bangkok, Thailand, 10330 Siriraj Hospital Bangkok, Thailand, 10700 Uganda Joint Clinical Research Centre Kampala, Uganda Less <<
NCT00665847 HIV-1 Phase 2 Completed - -
NCT00665847 - Completed - -
NCT01335620 HIV Phase 1 Completed - United Kingdom ... More >> Chelsea & Westminster Hospital NHS Trust London, United Kingdom, SW10 9TH Imperial College Healthcare NHS Trust London, United Kingdom, W2 1NY Less <<
NCT01845298 HIV Infection Not Applicable Completed - United States, Pennsylvania ... More >> Drexel University College of Medicine Philadelphia, Pennsylvania, United States, 19102 Less <<
NCT01585753 - Completed - Argentina ... More >> Hospital General de Agudos "Dr. José María Ramos Mejía" Buenos Aires, Argentina, C1221ADC Fundacion IDEAA Buenos Aires, Argentina, C1405CKC Hospital Italiano de Buenos Aires Buenos Aires, Argentina Australia, New South Wales St. Vincent's Hospital Sydney, New South Wales, Australia, 2010 Germany Johann Wolfgang Goethe-University Hospital, Medical HIVCENTER Frankfurt, Frankfurt am Main, Germany, 60590 Thailand Chulalongkorn University Hospital Bangkok, Thailand, 10330 Less <<
NCT02411071 - Unknown December 2016 Germany ... More >> HIV outpatient center, Dept. for Dermatology and Venerolgy, University Duisburg-Essen, University Hospital Essen Essen, NRW, Germany, 45147 Less <<
NCT01232361 - Completed - United States, Alabama ... More >> Univ. of Alabama Birmingham NICHD CRS (5096) Birmingham, Alabama, United States, 35294 United States, California Miller Children's Hospital Long Beach (5093) Long Beach, California, United States, 90806 Usc La Nichd Crs (5048) Los Angeles, California, United States, 90033 UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CR (3601) Los Angeles, California, United States, 90095 Univ of California, San Diego (UCSD) (4601) San Diego, California, United States, 92103 United States, Colorado Childrens Hospital (U. Colorado, Denver) NICHD CRS (5052) Denver, Colorado, United States, 80218-1088 United States, District of Columbia Children's National Med. Ctr. Washington DC NICHD CRS (5015) Washington, District of Columbia, United States, 20010 United States, Florida South Florida CDC Ft Lauderdale NICHD CRS (5055) Ft Lauderdal, Florida, United States, 33316 Univ of Miami Pediatric/Perinatal HIV/AIDS (4201) Miami, Florida, United States, 33136 United States, Illinois Chicago Children's CRS (4001) Chicago, Illinois, United States, 60611 Rush University Cook County Hospital NICHD CRS (5083) Chicago, Illinois, United States, 60612 United States, Maryland Johns Hopkins University NICHD CRS (5092) Baltimore, Maryland, United States, 21287 United States, Massachusetts Boston Medical Center Ped. HIV Program NICHD CRS (5011) Boston, Massachusetts, United States, 02118 WNE Maternal Pediatric Adolescent AIDS CRS (7301) Worcester, Massachusetts, United States, 01605 United States, Michigan Wayne State University/Children's Hospital of Michigan NICHD CRS (5041) Detroit, Michigan, United States, 48201 United States, New York Jacobi Med. Ctr. Bronx NICHD CRS (5013) Bronx, New York, United States, 10461 New York University NY (5012) New York, New York, United States, 10016 Columbia IMPAACT Center (4101) New York, New York, United States, 10032 SUNY Stony Brook (5040) Stony Brook, New York, United States, 11794-8111 United States, Tennessee St. Jude Childrens Research Hospital, Memphis (6501) Memphis, Tennessee, United States, 38105-2794 United States, Texas Texas Children's Hosp. CRS (3801) Houston, Texas, United States, 77030 Puerto Rico San Juan City Hosp. PR NICHD CRS (5031) San Juan, Puerto Rico, 00927 Less <<
NCT00537394 - Completed - -
NCT03256422 HIV Infections Phase 3 Active, not recruiting December 2020 -
NCT01026727 HIV Infections Phase 2 Terminated(For strategic buisn... More >>ess reasons.) Less << - -
NCT01923311 - Terminated - -
NCT02588820 HIV Infections Phase 3 Unknown November 2018 Spain ... More >> Hospital Clínic i Provincial de Barcelona Recruiting Barcelona, Spain, 08036 Contact: Josep Maria Miró, MD    +34 337 54 00 Less <<
NCT00537966 HIV Infections Not Applicable Recruiting January 2025 Switzerland ... More >> University of Zurich Recruiting Zurich, Switzerland Contact: Huldrych. Günthard       Huldrych.guenthard@usz.ch Less <<
NCT01908660 - Completed - Spain ... More >> Hospital Universitario de Valme Seville, Spain, 41014 Less <<
NCT00537394 HIV Infections Phase 3 Completed - -
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NCT00752310 Pharmacokinetics PHASE1 COMPLETED 2025-08-08 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.13mL

1.83mL

0.91mL

18.26mL

3.65mL

1.83mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories