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Chemical Structure| 147867-65-0 Chemical Structure| 147867-65-0

Structure of DSPE-mPEG (MW 2000)
CAS No.: 147867-65-0

Chemical Structure| 147867-65-0

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Liu, Yichen ; Kim, Gaeun ; Zhu, Runyao ; Jeon, Hyunsu ; Wang, Yichun ;

Abstract: Tumor hypoxia and poor penetration of therapeutics across tumor-microenvironment barriers remain major obstacles to effective cancer therapy, including photodynamic therapy (PDT). Here we introduce a nanochirality-programmed assembly (L-Chi-GAIN) in which nanochirality drives site-selective assembly that activates oxygen-independent Type-I reactive oxygen species (ROS) generation and reduces hyaluronan-mediated matrix adhesion, thereby permitting deep intratumoral therapy. Glycosylation imparts structural chirality to graphene quantum dots (GQDs), directing site-selective assembly of indocyanine green (ICG) that turns on photoinduced electron transfer (PET), producing a 64-fold increase in ROS relative to free ICG. Nanochirality also modulates assembly–extracellular matrix (ECM) interactions. L-GQDs show a less favorable hyaluronan binding free energy (ΔGbind), thus accelerating interstitial transport and resulting in ∼21-fold deeper tumor penetration by L-Chi-GAIN than conventional nanocarriers. Under near-infrared irradiation, L-Chi-GAIN elicits strong oxidative stress and triggers Gasdermin-D (GSDMD)-dependent pyroptosis, leading to significant suppression of tumor growth. This work offers a nanochirality-guided design strategy for PDT in deep tumors by coupling site-selective assembly with stereoselective navigation of the ECM.

Keywords: Graphene quantum dot ; Solid tumor ; Type-I reactive oxygen species ; Chirality ; Extracellular matrix

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Product Details of [ 147867-65-0 ]

CAS No. :147867-65-0
SMILES Code : NONE
MDL No. :MFCD00240077
InChI Key :SRLOHQKOADWDBV-NRONOFSHSA-M
Pubchem ID :86278269

Safety of [ 147867-65-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338
 

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