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Chemical Structure| 71879-55-5 Chemical Structure| 71879-55-5
Chemical Structure| 71879-55-5

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Product Details of Ethyl3-(4-Piperidyl)propanoate

CAS No. :71879-55-5
Formula : C10H19NO2
M.W : 185.26
SMILES Code : CCOC(=O)CCC1CCNCC1
MDL No. :MFCD12028379
InChI Key :XHMFMSVBWJZLBF-UHFFFAOYSA-N
Pubchem ID :10012639

Safety of Ethyl3-(4-Piperidyl)propanoate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Ethyl3-(4-Piperidyl)propanoate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71879-55-5 ]

[ 71879-55-5 ] Synthesis Path-Downstream   1~2

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  • [ 71879-55-5 ]
  • [ 154775-43-6 ]
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  • [ 71879-55-5 ]
  • [ 7037-49-2 ]
YieldReaction ConditionsOperation in experiment
Example 85 (Preparation of Compound 88) To a mixture of ethyl 3-(4-piperidinyl)butyrate (870 mg) and tetrahydrofuran (10 mL) was added lithium aluminum hydride (178 mg) at 0°C, and the mixture was stirred for 6 hours. Water (0.18 mL), a 25percent potassium hydroxide solution (0.18 mL) and water (0.54 mL) were sequentially added and the mixture was stirred for 14 hours. Insolubles were filtered off using celite and mother liquor was concentrated to obtain a pale yellow oily matter (590 mg). A mixture of the obtained matter (167 mg), 4-fluoro-1-naphthonitrile (100 mg), potassium carbonate (202 mg) and dimethylsulfoxide (1.0 mL) was stirred at 100°C for 3 hours. After cooling to room temperature, the reactant was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain 4-[4-(3-hydroxypropyl)-1-piperidinyl]-1-naphthonitrile (105 mg) (Compound 88). mp 114 - 115°C. 1H-NMR (300 MHz, CDCl3) delta: 1.30 (1H, t, J=5.4 Hz), 1.43-1.54 (4H, m), 1.57-1.72 (3H, m), 1.90-1.92 (2H, m), 2.80 (2H, t, J=11.7 Hz), 3.49-3.54 (2H, m), 3.70 (2H, td, J=6.6 and 5.4 Hz), 7.00 (1H, d, J=8.1 Hz), 7.56 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.65 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.82 (1H, d, J=8.1 Hz), 8.14-8.20 (2H, m). IR (KBr) 2932, 2216, 1572 cm-1
 

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