* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With hydrogenchloride; Adam’s catalyst; hydrogen In methanol; water for 46 h; Inert atmosphere
Under an atmosphere of argon platinum(IV)oxide (1.45 g, 6.4 mmol) was added to a solution of 16 (10.0 g, 72.89 mmol) in MeOH (110 mL) and 32percent hydrochloric acid (18 mL). The mixture was vigorously stirred under a low pressure of hydrogen (8 kPa) for 46 h. The major part of the catalyst was removed by filtration and the volatiles were removed under reduced pressure. The oily residue was taken up in 15percent aq NaOH (80 mL) and the product was extracted with CH2Cl2 (150 and 3 * 100 mL). The pooled extracts were washed with water (20 mL) and dried over Na2SO4. Evaporation of the volatiles and drying in vacuo yielded product 17 as a white crystalline, compact solid (10.3 g, 98percent) mp 58-60 °C. Rf = 0.2 (CH2Cl2/MeOH/28percent aq NH3 50:10:1). IR (Nujol) 3290, 1320 cm-1. 1H NMR (300 MHz, CD3OD) δ (ppm) 1.08-1.23 (m, 2H), 1.27-1.36 (m, 2H), 1.36-1.49 (m, 1H), 1.53-1.63 (m, 2H), 1.74 (br d, 2H, J ca 13.4 Hz), 2.59 (dt, 2H, J 12.4 2.6 Hz), 3.04 (td, 2H, J 12.4 2.9 Hz), 3.56 (t, 2H, J 6.6 Hz). 13C NMR (75 MHz, CD3OD) δ (ppm) 31.5, 34.8, 35.2, 38.0, 47.9, 64.0. MS (ESI, MeOH) m/z (percent) 287 (36) [2M+H]+, 144 (100) [M+H]+. C8H17NO (143.2).
Reference：
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 23, # 14, p. 3970 - 3990
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 16, p. 2537 - 2551
[3] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552
[4] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639
[5] Journal of Polymer Science, 1959, vol. 40, p. 377,384
[6] Journal of the American Chemical Society, 1947, vol. 69, p. 630,631
[7] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 15, p. 2031 - 2034
[8] Patent: US5714497, 1998, A,
[9] Patent: US2010/4450, 2010, A1, . Location in patent: Page/Page column 14
[10] Patent: WO2016/124508, 2016, A1,
[11] Patent: WO2018/68297, 2018, A1, . Location in patent: Page/Page column 55
2
[ 93524-95-9 ]
[ 7037-49-2 ]
Yield
Reaction Conditions
Operation in experiment
43%
With palladium 10% on activated carbon; hydrogen In acetic acid at 20℃; for 6 h; Inert atmosphere
General procedure: A solution of 3-(2’-pyridinyl)-2-propyn-1-ol (1a), or 3-(3’-pyridinyl)-2-propyn-1-ol (1b), or 3-(4’-pyridinyl)-2-propyn-1-ol (1c, 30 mg, 0.23 mmol, 1.0 eq) in AcOH (5.6 mL) was treated with 10percent Pd/C (1.2 g, 1.13 mmol, 5.0 eq) and hydrogenated at balloon pressure at room temperature. After stirring for 6 h at room temperature, the insoluble was separated by filtration through Celite eluting with MeOH and then washed with Et2O. The filtrate afforded 3-piperidin-2’-yl-propan-1-ol (2a) as a colorless solid (18.5 mg, 0.13 mmol, 57percent);
Reference：
[1] Journal of the American Chemical Society, 1947, vol. 69, p. 630,631
[2] Patent: US2008/306082, 2008, A1, . Location in patent: Page/Page column 6
[3] Patent: US2010/4450, 2010, A1, . Location in patent: Page/Page column 14
7
[ 7037-49-2 ]
[ 24424-99-5 ]
[ 156185-63-6 ]
Yield
Reaction Conditions
Operation in experiment
88%
at 20℃; for 2 h;
Preparation 144-(3-Aminopropyl)-piperidine-1-carboxylic acid tert-butyl ester(A). Preparation of 4-(3-hydroxypropyl)-piperidine-1-carboxylic acid tert-butyl ester; Di-tert-butyl dicarbonate (3.66 g, 16.8 mmol) is added to a stirred solution of 3-piperidin-4-yl-propan-1-ol (1.60 g, 11.2 mmol) in anhydrous dichloromethane (20 mL) at ambient temperature under nitrogen. The resultant mixture is allowed to stir for 2 hours. The mixture is directly subjected to chromatography purification on silica gel and eluted with MeOH in dichloromethane 0-3percent to give the title compound as a clear oil (2.40 g, 88percent yield).
EXAMPLE 105 To a stirred mixture of methylene chloride (400 ml) and water (40 ml) are added dropwise benzyloxycarbonyl chloride (100 g) and a solution of 3-(4-piperidyl)propanol (84 g) and triethylamine (65 g) in methylene chloride (100 ml) for 45 minutes at room temperature. After addition is completed, stirring is continued for further 1 hour. The methylene chloride layer is separated, washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Vacuum distillation of the oily residue is carried out to remove the low boiling material (50°-60° C./5 mmHg). 3-(1-Benzyloxycarbonyl-4-piperidyl)propanol (110 g) is obtained as a yellow oily residue. IR numaxneat cm-1: 3400(OH), 1680(C=O)
4-[3-(4-{2-(butane-1-sulfonylamino)-2-[2-(1,1-dimethyl-3-oxo-propyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-propyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester[ No CAS ]
4-[4-(4-{2-(butane-1-sulfonylamino)-2-[2-(1,1-dimethyl-3-oxo-propyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-butyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester[ No CAS ]
4-[3-(4-{2-(butane-1-sulfonylamino)-2-[2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-propyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester[ No CAS ]
4-[4-(4-{2-(butane-1-sulfonylamino)-2-[2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-butyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester[ No CAS ]
4-[4-(4-{3-[2-(4-chloro-phenoxymethyl)-4-methyl-benzoimidazol-1-yl]-propyl}-piperidin-1-yl)-butyl]-piperazine-1-carboxylic acid <i>tert</i>-butyl ester[ No CAS ]
4-(4-{3-[2-(4-chloro-phenoxymethyl)-4-methyl-benzoimidazol-1-yl]-propyl}-piperidin-1-yl)-butyraldehyde; compound with GENERIC INORGANIC NEUTRAL COMPONENT[ No CAS ]
2-(4-chloro-phenoxymethyl)-4-methyl-1-[3-(1-{4-[4-(2-morpholin-4-yl-ethyl)-piperazin-1-yl]-butyl}-piperidin-4-yl)-propyl]-1<i>H</i>-benzoimidazole[ No CAS ]
2-(4-chloro-phenoxymethyl)-4-methyl-1-[3-(1-{4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-piperidin-4-yl)-propyl]-1<i>H</i>-benzoimidazole[ No CAS ]
1-(3-{1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-butyl]-piperidin-4-yl}-propyl)-2-(4-chloro-phenoxymethyl)-4-methyl-1<i>H</i>-benzoimidazole[ No CAS ]
With potassium carbonate; In acetonitrile; for 12h;Heating / reflux;
Step A : 3- (1-Cyclopentylpiperidin-4-yl)-1-propanol To a solution of 3-(PIPERIDIN-4-YL)-1-PROPANOL (4.7 g, 33 MMOL) in acetonitril (100 mL) was added potassium carbonate (25 g, 180 MMOL) and cyclopentylbromide (24.5 g, 164 MMOL) and the reaction mixture was stirred at reflux temperature overnight. The mixture was al- lowed to cool, then filtered and the solvent evaporated. The residue was dissolved in ethyl acetate (150 mL) and the organic mixture was dried (MGS04). The mixture was filtered and the solvent was evaporated. The residue was treated with diethyl ether (100 mL) and the or- ganic phase was decanted and evaporated. This afforded 5.8 g of 3- (1-CYCLOPENTYLPIPERIDIN- 4-YL)-1-PROPANOL contaminated with probably CYCLOPENTYLBROMIDE.APOS;H NMR (400 MHz, CDCI3) 8 1.2-2. 0 (m, 17H), 2.05-2. 15 (m, 1H), 2.45 (pent. , 1H), 2.95-3. 05 (m, 2H), 3.55-3. 65 (m, 2H), 4.28-4. 36 (m, 2H).
With potassium carbonate; In acetonitrile;Heating / reflux;
To a solution of 3-(piperidin-4-yl)-1-propanol (4.7 g, 33 mmol) in acetonitril (100 mL) was added potassium carbonate (25 g, 180 mmol) and cyclopentylbromide (24.5 g, 164 mmol) and the reaction mixture was stirred at reflux temperature overnight. The mixture was allowed to cool, then filtered and the solvent evaporated. The residue was dissolved in ethyl acetate (150 mL) and the organic mixture was dried (MgSO4). The mixture was filtered and the solvent was evaporated. The residue was treated with diethyl ether (100 mL) and the organic phase was decanted and evaporated. This afforded 5.8 g of 3-(1-cyclopentylpiperidin-4-yl)-1-propanol contaminated with probably cyclopentylbromide. 1H NMR (400 MHz, CDCl3) delta 1.2-2.0 (m, 17H), 2.05-2.15 (m, 1H), 2.45 (pent., 1H), 2.95-3.05 (m, 2H), 3.55-3.65 (m, 2H), 4.28-4.36 (m, 2H).
4-[4-(3-hydroxypropyl)-1-piperidinyl]-1-naphthonitrile[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In tetrahydrofuran; water; dimethyl sulfoxide; at 100℃; for 3h;
Example 85 (Preparation of Compound 88) To a mixture of ethyl 3-(4-piperidinyl)butyrate (870 mg) and tetrahydrofuran (10 mL) was added lithium aluminum hydride (178 mg) at 0°C, and the mixture was stirred for 6 hours. Water (0.18 mL), a 25percent potassium hydroxide solution (0.18 mL) and water (0.54 mL) were sequentially added and the mixture was stirred for 14 hours. Insolubles were filtered off using celite and mother liquor was concentrated to obtain a pale yellow oily matter (590 mg). A mixture of the obtained matter (167 mg), 4-fluoro-1-naphthonitrile (100 mg), potassium carbonate (202 mg) and dimethylsulfoxide (1.0 mL) was stirred at 100°C for 3 hours. After cooling to room temperature, the reactant was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain 4-[4-(3-hydroxypropyl)-1-piperidinyl]-1-naphthonitrile (105 mg) (Compound 88). mp 114 - 115°C. 1H-NMR (300 MHz, CDCl3) delta: 1.30 (1H, t, J=5.4 Hz), 1.43-1.54 (4H, m), 1.57-1.72 (3H, m), 1.90-1.92 (2H, m), 2.80 (2H, t, J=11.7 Hz), 3.49-3.54 (2H, m), 3.70 (2H, td, J=6.6 and 5.4 Hz), 7.00 (1H, d, J=8.1 Hz), 7.56 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.65 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.82 (1H, d, J=8.1 Hz), 8.14-8.20 (2H, m). IR (KBr) 2932, 2216, 1572 cm-1
Example 85 (Preparation of Compound 88) To a mixture of ethyl 3-(4-piperidinyl)butyrate (870 mg) and tetrahydrofuran (10 mL) was added lithium aluminum hydride (178 mg) at 0°C, and the mixture was stirred for 6 hours. Water (0.18 mL), a 25percent potassium hydroxide solution (0.18 mL) and water (0.54 mL) were sequentially added and the mixture was stirred for 14 hours. Insolubles were filtered off using celite and mother liquor was concentrated to obtain a pale yellow oily matter (590 mg). A mixture of the obtained matter (167 mg), 4-fluoro-1-naphthonitrile (100 mg), potassium carbonate (202 mg) and dimethylsulfoxide (1.0 mL) was stirred at 100°C for 3 hours. After cooling to room temperature, the reactant was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain 4-[4-(3-hydroxypropyl)-1-piperidinyl]-1-naphthonitrile (105 mg) (Compound 88). mp 114 - 115°C. 1H-NMR (300 MHz, CDCl3) delta: 1.30 (1H, t, J=5.4 Hz), 1.43-1.54 (4H, m), 1.57-1.72 (3H, m), 1.90-1.92 (2H, m), 2.80 (2H, t, J=11.7 Hz), 3.49-3.54 (2H, m), 3.70 (2H, td, J=6.6 and 5.4 Hz), 7.00 (1H, d, J=8.1 Hz), 7.56 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.65 (1H, ddd, J=8.4, 6.9 and 1.5 Hz), 7.82 (1H, d, J=8.1 Hz), 8.14-8.20 (2H, m). IR (KBr) 2932, 2216, 1572 cm-1
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.5h;
Preparation 2: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile. A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in CH2Cl2 at 00C. A solution of BrCN (17.8 g, 0.17 mol) in CH2Cl2 (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The CH2Cl2 solution was dried (MgSOzi), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of CH2Cl2, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: m/z (ES+) = 169.1 [M+ H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.5h;
Preparation 1: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile. A slurry of NaHCpsi3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in CH2Cl2 at 00C. A solution of BrCN (17.8 g, 0.17 mol) in CH2Cl2 (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCpsi3 and brine. The CH2Cl2 solution was dried (MgSOzi), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of CH2Cl2, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: m/z (ES+) = 169.1 [M + H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.5h;
Preparation 4: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile. A slurry OfNaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-yl-propan-l-ol (20.0 g, 0.14 mol) in CH2Cl2 at 00C. A solution of BrCN (17.8 g, 0.17 mol) in CH2Cl2 (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The CH2Cl2 solution was dried (MgSOzi), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of CH2Cl2, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.5h;
Preparation 1: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile. A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in CH2Cl2 at 00C. A solution of BrCN (17.8 g, 0.17 mol) in CH2Cl2 (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCpsi3 and brine. The CH2Cl2 solution was dried (MgSOzi), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of CH2Cl2, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.5h;
Preparation 1: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile. A slurry OfNaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in CH2Cl2 at 00C. A solution of BrCN (17.8 g, 0.17 mol) in CH2Cl2 (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The CH2Cl2 solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of CH2Cl2, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M+ H]+.
In dichloromethane; water; at 0℃;
Example II. 3-Isopropyl-5-(4-(2-(5-(4-(methylsulfonyl)piperazin-l- yl)thiazol-2-yl)ethyl)piperidin-l-yl)-l,2,4-oxadiazole. <n="83"/>He Hf[00196] Step A: To a stirred a suspension of sodiumhydrogencarbonate (2.80 g, 33.3 mmol) in water (1.5 mL) is added Ha hydrochloride salt (2.00 g, 11.1 mmol) and dichloromethane (2 mL). The mixture is cooled in ice/water bath and stirred. A solution of cyanogen bromide (1.42 g, 13.4 mmol) in dichloromethane (3 mL) is added over a period of 1 hour. The cold bath is removed and the reaction is stirred overnight. 0.33 g of Na2Cpsi3 is added to ensure the reaction is basic. The reaction is diluted with dichloromethane (20 mL), dried with MgSCU. The mixture is filtered, washed with dichloromethane, and evaporated to give lib; ESIMS m/z for (M+H)+ C9H17N2O calcd.: 169.1, found: 169.1.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃;
A slurry of NaHCO3 (35 2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidm-4-ylpropan-l-ol (20 0 g, 0 14 mol) in DCM at 00C A solution of BrCN (17 8 g, 0.17 mol) in DCM (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h The reaction was then stirred at 2O0C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The DCM solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of DCM, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+ (Method A).
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃;
A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in DCM at 00C. A solution of BrCN (17.8 g, 0.17 mol) in DCM (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at ambient temperature for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The DCM solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of DCM, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃;
A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 inL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in DCM at 00C. A solution of BrCN (17.8 g, 0.17 mol) in DCM (19 inL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The DCM solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of DCM, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M+ H]+.
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.51667h;
A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in DCM at 00C. A solution of BrCN (17.8 g, 0.17 mol) in DCM (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 and brine. The DCM solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of DCM, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+ (Method A).
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20℃; for 2.51667h;
Preparation 1: 4-(3-Hydroxypropyl)piperidine-l-carbonitrile; A slurry of NaHCO3 (35.2 g, 0.42 mol) in H2O (70 mL) was added to a stirred solution of 3-piperidin-4-ylpropan-l-ol (20.0 g, 0.14 mol) in DCM at 00C. A solution of BrCN (17.8 g, 170 mmol) in DCM (19 mL) was added to the reaction over 1 min, then stirring was continued at 00C for 0.5 h. The reaction was then stirred at 200C for 2 h, before being washed with saturated aqueous NaHCO3 solution and brine. The DCM solution was dried (MgSO4), filtered and concentrated in vacuo to furnish an oil that was dissolved in a small amount of DCM, before being filtered through a SiO2 pad, eluting with EtOAc. The filtrate was concentrated under reduced pressure to afford the title compound: mlz (ES+) = 169.1 [M + H]+.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
