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Chemical Structure| 58-63-9 Chemical Structure| 58-63-9

Structure of Inosine
CAS No.: 58-63-9

Chemical Structure| 58-63-9

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Inosine is an endogenous purine nucleoside with immunomodulatory, neuroprotective, and analgesic properties.

Synonyms: 9-β-D-Ribofuranosylhypoxanthine; NSC 20262; INO 495

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Product Citations

Product Citations

Walczak, Juliusz Maksymilian ; Iwaszkiewicz-Grzes, Dorota ; Ziomkowska, Michalina ; Sliwka-Kaszynska, Magdalena ; Dasko, Mateusz ; Trzonkowski, Piotr , et al.

Abstract: The group of 18 new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5′-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis of 14 of them employed uronium-type activating system (TBTU/HOBt/DIPEA) while 4 of them concerned phosphonic acid anhydride method (T3P/Py) facilitating amides to be obtained in moderate to excellent yields without the need of phenolic group protection. Most of optimised protocols did not require complicated reaction work-ups, including chromatographic, solvent-consuming methods. The biological activity assay was performed on the T-Jurkat cell line and peripheral mononuclear blood cells (PBMCs) which are both dedicated for antiproliferative activity determination. Each of designed derivatives was characterised by reduced cytotoxicity and benzoxazole analogue (A2) revealed the most promising activity. Subsequently, an observed structure-activity relationship was discussed.

Keywords: Mycophenolic acid ; amide derivatives ; heterocycles ; benzoxazole ; IMPDH inhibition

Alternative Products

Product Details of Inosine

CAS No. :58-63-9
Formula : C10H12N4O5
M.W : 268.23
SMILES Code : O=C1N=CNC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
Synonyms :
9-β-D-Ribofuranosylhypoxanthine; NSC 20262; INO 495
MDL No. :MFCD00066770
InChI Key :UGQMRVRMYYASKQ-KQYNXXCUSA-N
Pubchem ID :135398641

Safety of Inosine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Inosine

DNA

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02614469 Healthy PHASE1 COMPLETED 2025-05-16 Covance Clinical Research Unit... More >> Inc., Evansville, Indiana, 47710, United States Less <<
NCT00067327 Multiple Sclerosis, Relapsing-... More >>Remitting Less << PHASE2 COMPLETED 2025-09-05 Hospital of the University of ... More >>Pennsylvania, Philadelphia, Pennsylvania, 19104, United States Less <<
NCT02288091 Amyotrophic Lateral Sclerosis PHASE1 COMPLETED 2025-03-16 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.64mL

3.73mL

1.86mL

37.28mL

7.46mL

3.73mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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