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Chemical Structure| 64-10-8 Chemical Structure| 64-10-8
Chemical Structure| 64-10-8

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Synonyms: 1-Phenylurea; Phenylurea

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Product Details of N-Phenylurea

CAS No. :64-10-8
Formula : C7H8N2O
M.W : 136.15
SMILES Code : OC(=N)NC1=CC=CC=C1
Synonyms :
1-Phenylurea; Phenylurea
MDL No. :MFCD00007944
InChI Key :LUBJCRLGQSPQNN-UHFFFAOYSA-N
Pubchem ID :6145

Safety of N-Phenylurea

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of N-Phenylurea

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64-10-8 ]

[ 64-10-8 ] Synthesis Path-Downstream   1~7

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YieldReaction ConditionsOperation in experiment
16% In water; at 150℃; for 0.0833333h;Microwave irradiation; Intermediate 1: Ethyl [4-(4-[(2-anilino-l,3-oxazol-5-v-)carbonyllamino|phenv0- cyelohexyl] acetate; i) Ethyl 2-anilino-l,3-oxazole-5-earboxylate; Ethyl 2-chloro-3-oxopropanoate (Ref: Heterocycles, 1991, 32(4), 693, 520 mg, 3.47 mmol) was added in one portion to N-phenylurea (566 mg, 4.16 mmol) in water (1 mL) and the reaction mixture was heated to 150C for 5 mins in the microwave. The resulting precipitate was washed with water and then triturated with EtOAc. The filtrate was concentrated in vacuo and purified by reverse phase preparative HPLC to give the product as a white solid (130 mg, 16%).1H NMR deltal.26 (t, 3H), 4.21 (q, 2H), 7.07 (t, IH), 7.33 (t, 2H), 7.46 (d, 2H), 8.19 (s, IH), 9.42 (s, IH); MS m/e MH+ 233.
  • 4
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  • [ 93075-09-3 ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride; EXAMPLE 24 STR39 A mixture of alpha-trifluoromethylacrylic acid (350 mg; 2.5 mmoles), phenylurea (353 mg; 2.6 mmoles) and acetic anhydride (2 ml) was heated at 100 C. with stirring for 1 hour. After cooling, the precipitated solid was collected by filtration to give 298 mg (yield: 46%) of 3-phenyl-5-trifluoromethyldihydrouracil. The solvent was evaporated from the filtrate, and the residue was recrystallized from chloroform/hexane to give additional 133 mg (yield: 21%) of the above product. The total yield was 67%. The physical and spectral properties of the resulting 3-phenyl-5-trifluoromethyldihydrouracil completely agreed with those of the product obtained in Example 11.
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  • 1,1',1''-((1E,1'E,1''E)-(2,4,6-trioxocyclohexane-1,3,5-triylidene)tris(methaneylylidene))tris(3-phenylurea) [ No CAS ]
 

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